Bronchial Thermoplasty Questions & Answers

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9. Moore WC, Bleecker ER, Curran-Everett D, Erzurum SC, Ameredes BT, et al. Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol. 2007 Feb. 119 (2):405-13. [QxMD MEDLINE Link]. [Full Text].

10. Miller RJ, Murgu SD. Interventional pulmonology for asthma and emphysema: bronchial thermoplasty and bronchoscopic lung volume reduction. Semin Respir Crit Care Med. 2014 Dec. 35 (6):655-70. [QxMD MEDLINE Link]. [Full Text].

11. Siddiqui S, Gonem S, Wardlaw AJ. Advances in the management of severe asthma. Semin Respir Crit Care Med. 2012 Dec. 33 (6):666-84. [QxMD MEDLINE Link]. [Full Text].

12. Menzella F, Zucchi L, Piro R, Galeone C, Castagnetti C, Facciolongo N. A budget impact analysis of bronchial thermoplasty for severe asthma in clinical practice. Adv Ther. 2014 Jul. 31 (7):751-61. [QxMD MEDLINE Link]. [Full Text].

13. Singh SK, Tiwari KK. Bronchial thermoplasty: a non-pharmacological approach. Clin Respir J. 2015 Apr 27. 35 (6):655-70. [QxMD MEDLINE Link]. [Full Text].

14. Cangelosi MJ, Ortendahl JD, Meckley LM, Bentley TG, Anene AM, Shriner KM, et al. Cost-effectiveness of bronchial thermoplasty in commercially-insured patients with poorly controlled, severe, persistent asthma. Expert Rev Pharmacoecon Outcomes Res. 2015 Apr. 15 (2):357-64. [QxMD MEDLINE Link]. [Full Text].

15. Tan LD, Kenyon N, Yoneda KY, Louie S. Bronchial thermoplasty: implementing best practice in the era of cost containment. J Asthma Allergy. 2017. 10:225-230. [QxMD MEDLINE Link]. [Full Text].

16. [Guideline] National Asthma Education and Prevention Program. Expert Panel Report 3 (EPR-3): Guidelines for the Diagnosis and Management of Asthma-Summary Report 2007. J Allergy Clin Immunol. 2007 Nov. 120 (5 Suppl):S94-138. [QxMD MEDLINE Link]. [Full Text].

17. Blaiss MS, Castro M, Chipps BE, Zitt M, Panettieri RA Jr, Foggs MB. Guiding principles for use of newer biologics and bronchial thermoplasty for patients with severe asthma. Ann Allergy Asthma Immunol. 2017 Dec. 119 (6):533-540. [QxMD MEDLINE Link].

18. Gordon IO, Husain AN, Charbeneau J, Krishnan JA, Hogarth DK. Endobronchial biopsy: a guide for asthma therapy selection in the era of bronchial thermoplasty. J Asthma. 2013 Aug. 50 (6):634-41. [QxMD MEDLINE Link]. [Full Text].

19. Andrychiewicz A, Gorka K, Reid M, Soja J, Sladek K, Szczeklik W. Modern methods for the endoscopic treatment of obstructive pulmonary diseases. J Asthma. 2015 Jan 13. 50 (6):1-19. [QxMD MEDLINE Link]. [Full Text].

20. Cox G, Miller JD, McWilliams A, Fitzgerald JM, Lam S. Bronchial thermoplasty for asthma. Am J Respir Crit Care Med. 2006 May 1. 173 (9):965-9. [QxMD MEDLINE Link]. [Full Text].

21. Castro M, Rubin AS, Laviolette M,et. al. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. Am J Respir Crit Care Med. 2010 Jan 15. 181 (2):116-24. [QxMD MEDLINE Link]. [Full Text].

22. Pavord ID, Cox G, Thomson NC, Rubin AS, Corris PA, Niven RM, et al. Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma. Am J Respir Crit Care Med. 2007 Dec 15. 176 (12):1185-91. [QxMD MEDLINE Link]. [Full Text].

23. [Guideline] Cloutier MM, Baptist AP, Blake KV, Brooks EG, Bryant-Stephens T, DiMango E, et al. 2020 Focused Updates to the Asthma Management Guidelines: A Report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group. J Allergy Clin Immunol. 2020 Dec. 146 (6):1217-1270. [QxMD MEDLINE Link]. [Full Text].

24. Danek CJ, Lombard CM, Dungworth DL, Cox PG, Miller JD, Biggs MJ, et al. Reduction in airway hyperresponsiveness to methacholine by the application of RF energy in dogs. J Appl Physiol (1985). 2004 Nov. 97 (5):1946-53. [QxMD MEDLINE Link]. [Full Text].

25. Miller JD, Cox G, Vincic L, Lombard CM, Loomas BE, Danek CJ. A prospective feasibility study of bronchial thermoplasty in the human airway. Chest. 2005 Jun. 127 (6):1999-2006. [QxMD MEDLINE Link]. [Full Text].

26. Woodruff PG, Dolganov GM, Ferrando RE, Donnelly S, Hays SR, Solberg OD, et al. Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression. Am J Respir Crit Care Med. 2004 May 1. 169 (9):1001-6. [QxMD MEDLINE Link]. [Full Text].

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28. Doherty DE. The pathophysiology of airway dysfunction. Am J Med. 2004 Dec 20. 117 Suppl 12A:11S-23S. [QxMD MEDLINE Link]. [Full Text].

29. Matsumoto H, Moir LM, Oliver BG, Burgess JK, Roth M, Black JL, et al. Comparison of gel contraction mediated by airway smooth muscle cells from patients with and without asthma. Thorax. 2007 Oct. 62 (10):848-54. [QxMD MEDLINE Link]. [Full Text].

30. Janssen LJ. Airway smooth muscle as a target in asthma and the beneficial effects of bronchial thermoplasty. J Allergy (Cairo). 2012. 2012:593784. [QxMD MEDLINE Link]. [Full Text].

31. Dyrda P, Tazzeo T, DoHarris L, Nilius B, Roman HN, Lauzon AM, et al. Acute response of airway muscle to extreme temperature includes disruption of actin-myosin interaction. Am J Respir Cell Mol Biol. 2011 Feb. 44 (2):213-21. [QxMD MEDLINE Link]. [Full Text].

32. Hamid Q, Song Y, Kotsimbos TC, Minshall E, Bai TR, Hegele RG, et al. Inflammation of small airways in asthma. J Allergy Clin Immunol. 1997 Jul. 100 (1):44-51. [QxMD MEDLINE Link]. [Full Text].

33. Kraft M. The distal airways: are they important in asthma?. Eur Respir J. 1999 Dec. 14 (6):1403-17. [QxMD MEDLINE Link]. [Full Text].

34. Ingram RH Jr, McFadden ER Jr. Localization and mechanisms of airway responses. N Engl J Med. 1977 Sep 15. 297 (11):596-600. [QxMD MEDLINE Link]. [Full Text].

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36. Jesudason EC. Airway smooth muscle: an architect of the lung?. Thorax. 2009 Jun. 64 (6):541-5. [QxMD MEDLINE Link]. [Full Text].

37. Fang L, Li J, Papakonstantinou E, Karakioulaki M, Sun Q, Schumann D, et al. Secreted heat shock proteins control airway remodeling: Evidence from bronchial thermoplasty. J Allergy Clin Immunol. 2021 Nov. 148 (5):1249-1261.e8. [QxMD MEDLINE Link].

38. Chaudhuri R, Rubin A, Sumino K, Lapa E Silva JR, Niven R, Siddiqui S, et al. Safety and effectiveness of bronchial thermoplasty after 10 years in patients with persistent asthma (BT10+): a follow-up of three randomised controlled trials. Lancet Respir Med. 2021 May. 9 (5):457-466. [QxMD MEDLINE Link].

39. Kirby M, Ohtani K, Lopez Lisbona RM, Lee AM, Zhang W, et al. Bronchial thermoplasty in asthma: 2-year follow-up using optical coherence tomography. Eur Respir J. 2015 May 28. 50 (7):799-801. [QxMD MEDLINE Link]. [Full Text].

40. Bonta PI, d'Hooghe J, Sterk PJ, Bel EH, Annema JT. Reduction of airway smooth muscle mass after bronchial thermoplasty: are we there yet?. Am J Respir Crit Care Med. 2015 May 15. 191 (10):1207-8. [QxMD MEDLINE Link]. [Full Text].

41. Aubier M, Pretolani M, Chanez P, Thabut G, Debray MP, Taille C, et al. Reply: reduction of airway smooth muscle mass by bronchial thermoplasty in patients with severe asthma. Am J Respir Crit Care Med. 2015 May 15. 191 (10):1208-9. [QxMD MEDLINE Link]. [Full Text].

42. Zanon M, Strieder DL, Rubin AS, Watte G, Marchiori E, Cardoso PFG, et al. Use of MDCT to Assess the Results of Bronchial Thermoplasty. AJR Am J Roentgenol. 2017 Oct. 209 (4):752-756. [QxMD MEDLINE Link].

43. Thomen RP, Sheshadri A, Quirk JD, Kozlowski J, Ellison HD, Szczesniak RD, et al. Regional ventilation changes in severe asthma after bronchial thermoplasty with (3)He MR imaging and CT. Radiology. 2015 Jan. 274 (1):250-9. [QxMD MEDLINE Link]. [Full Text].

44. Gudmundsson G, Gross TJ. Middle lobe syndrome. Am Fam Physician. 1996 Jun. 53 (8):2547-50. [QxMD MEDLINE Link]. [Full Text].

45. Facciolongo N, Menzella F, Lusuardi M, Piro R, Galeone C, Castagnetti C, et al. Recurrent lung atelectasis from fibrin plugs as a very early complication of bronchial thermoplasty: a case report. Multidiscip Respir Med. 2015. 10 (1):9. [QxMD MEDLINE Link]. [Full Text].

46. Balu A, Ryan D, Niven R. Lung abscess as a complication of bronchial thermoplasty. J Asthma. 2015 Mar 13. 2012:1-3. [QxMD MEDLINE Link]. [Full Text].

47. d'Hooghe JNS, van den Berk IAH, Annema JT, Bonta PI. Acute Radiological Abnormalities after Bronchial Thermoplasty: A Prospective Cohort Trial. Respiration. 2017. 94 (3):258-262. [QxMD MEDLINE Link]. [Full Text].

Said A Chaaban, MD Fellow in Pulmonary and Critical Care Medicine, Department of Internal Medicine, Henry Ford Health Systems

Disclosure: Nothing to disclose.

Javier I Diaz-Mendoza, MD Associate Professor of Medicine, Wayne State University School of Medicine; Program Director, Interventional Pulmonology Fellowship, Division of Pulmonary and Critical Care Medicine, Henry Ford Hospital

Javier I Diaz-Mendoza, MD is a member of the following medical societies: American Association for Bronchology and Interventional Pulmonology, American College of Chest Physicians, American Thoracic Society

Disclosure: Nothing to disclose.

Zab Mosenifar, MD, FACP, FCCP Geri and Richard Brawerman Chair in Pulmonary and Critical Care Medicine, Professor and Executive Vice Chairman, Department of Medicine, Medical Director, Women's Guild Lung Institute, Cedars Sinai Medical Center, University of California, Los Angeles, David Geffen School of Medicine

Zab Mosenifar, MD, FACP, FCCP is a member of the following medical societies: American College of Chest Physicians, American College of Physicians, American Federation for Medical Research, American Thoracic Society

Disclosure: Nothing to disclose.

Mahmoud Mahafzah, MBBS Fellow in Pulmonary and Critical Care Medicine, Center for Lung Health, Henry Ford Hospital

Mahmoud Mahafzah, MBBS is a member of the following medical societies: American Thoracic Society

Disclosure: Nothing to disclose.

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