Factor V Deficiency Clinical Presentation

Updated: Apr 04, 2023
  • Author: Olga Kozyreva, MD; Chief Editor: Perumal Thiagarajan, MD  more...
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Clinical manifestations of factor V deficiency include the following:

  • Bleeding into the skin
  • Excessive bruising with minor injuries
  • Nosebleeds
  • Bleeding gums
  • Excessive menstrual bleeding and prolonged or excessive loss of blood with surgery or trauma
  • Bleeding in mucosal tracts (gastrointestinal, urinary)
  • Hemarthrosis and flexion contracture
  • Bleeding during delivery and postpartum [20]
  • Intracerebral hemorrhages [21, 22]
  • Pulmonary hemorrhage [23]

The severity of bleeding symptoms is only partly related to the degree of factor V deficiency in plasma. Some patients with undetectable plasma levels of factor V experience only relatively mild bleeding. [1]


Physical Examination

The most common physical findings of factor V deficiency are ecchymoses, bleeding from mucosal surfaces, and pallor secondary to blood loss. Petechiae are uncommon because platelet numbers and function are not affected.