Factor VII Deficiency Differential Diagnoses

Updated: Sep 12, 2020
  • Author: Lucas Barreira Angelim, MD; Chief Editor: Perumal Thiagarajan, MD  more...
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Diagnostic Considerations

Other problems to be considered in the differential diagnosis include the following:

  • Liver disease

  • Oral anticoagulation (eg, with warfarin)

  • Factor X deficiency and some variants of factor IX deficiency: Patients with these conditions may also occasionally exhibit a prolonged prothrombin time (PT). In contrast to factor VII deficiency, the activated partial thromboplastin time (aPTT) is also prolonged.

  • Familial multiple factor deficiency type III: Inherited combined deficiency of prothrombin and factors VII, IX, and X has been reported. Levels of factor VII in this syndrome are lower than those in disorders with other vitamin K–dependent factors.

  • Factor V deficiency and lupus anticoagulants: These should be also considered in the differential for a prolonged PT.

  • Combined deficiency of factors VII and X: This has also been reported to occur, albeit rarely.

  • Liver disease, vitamin K deficiency, and oral coagulant-induced conditions: These conditions can be differentiated from factor VII deficiency by measuring other vitamin K–dependent factor levels, which are also decreased. These 3 conditions are associated with isolated prolongation of the PT, which is later followed by a prolonged aPTT.

Differential Diagnoses