Factor II Deficiency Medication

Updated: Mar 16, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Perumal Thiagarajan, MD  more...
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Medication Summary

The goals of pharmacotherapy in patients with factor II deficiency are to reduce morbidity and to prevent complications. Agents used include fresh frozen plasma (FFP), prothrombin complex concentrates (PCCs), and vitamin K.


Blood Products

Class Summary

Blood products are indicated for the correction of abnormal hemostatic parameters.

Fresh frozen plasma

Plasma is the fluid compartment of blood that contains the soluble clotting factors. Indications for using FFP include bleeding in patients with congenital coagulation defects and multiple coagulation factor deficiencies (severe liver disease).

Factor IX

Product made from pooled human plasma. Prothrombin complex concentrates contain factors II, VII, IX, X; protein C; and trace amounts of heparin to guard against thrombosis. Currently recommended for patients with coagulation factor inhibitors only.


Vitamins, Fat-Soluble

Class Summary

Fat-soluble vitamins may play essential role in the function of clotting factors.

Phytonadione (AquaMEPHYTON)

Fat-soluble vitamin K absorbed by the gut and stored in the liver. Necessary for the function of clotting factors in the coagulation cascade. Used to replace essential vitamins that are not obtained in sufficient quantities in the diet or to further supplement levels.