Factor II Deficiency Workup

Updated: Mar 16, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Perumal Thiagarajan, MD  more...
  • Print
Workup

Laboratory Studies

Coagulation study results in patients with factor II deficiency are as follows:

  • Prothrombin time (PT) is prolonged
  • Activated partial thromboplastin time (aPTT) is prolonged
  • Bleeding time is within reference ranges

Clotting factor assay results in patients with factor II deficiency are as follows:

  • In hypoprothrombinemia, functional and antigenic levels of factor II are decreased
  • In dysprothrombinemia, functional levels are decreased; antigenic levels are within reference ranges or are slightly decreased
  • In isolated factor II deficiency, assays of other clotting factors should reveal normal levels
  • In factor II deficiency due to liver disease, vitamin K deficiency, or vitamin K antagonist use, assays of other clotting factors reveal a decrease in the level of all vitamin K–dependent factors (ie, factor II, factor VII, factor IX, factor X, protein C)