Factor X Deficiency Medication

Updated: Mar 01, 2017
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Perumal Thiagarajan, MD  more...
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Medication

Medication Summary

The goals of pharmacotherapy in those with factor X deficiency are to reduce morbidity and to prevent complications. The following agents are used:

  • Fresh frozen plasma and prothrombin complex concentrates may be used to increase factor X levels
  • Supplemental vitamin K may be effective in acquired factor X deficiency related to vitamin K deficiency
  • Factor X, human (Coagadex) has been approved in the United States for hereditary factor X deficiency
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Blood-Product Derivatives

Class Summary

Blood-product derivatives are indicated for the correction of abnormal hemostatic parameters.

Fresh frozen plasma (FFP, Octaplas)

Clotting factor X is contained in plasma, the fluid component of blood. Indications include bleeding in patients with congenital coagulation defects and multiple coagulation factor deficiencies (severe liver disease). Octaplas is a solvent detergent treated, pooled FFP.

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Vitamins, Fat-Soluble

Class Summary

Vitamin K is key cofactor in activating clotting factors in the coagulation cascade.

Phytonadione (AquaMEPHYTON)

Absorbed by the gut and stored in the liver. Necessary for the function of clotting factors in the coagulation cascade. Used to replace essential vitamins that are not obtained in sufficient quantities in the diet or to further supplement levels.

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Coagulation Factors

Class Summary

Provides replacement for temporary correction of various coagulation factor deficiencies.

Factor X, human (Coagadex)

Factor X replacement that increases plasma levels of factor X and can temporarily correct the coagulation defect in these patients, as reflected by decrease in the aPTT and PT. Indicated for hereditary factor X deficiency for on-demand treatment and control of bleeding episodes. It is also indicated for perioperative management of bleeding in patients with mild hereditary factor X deficiency.

Factor IX complex (Bebulin, Bebulin VH, Profilnine SD)

Product made from pooled human plasma. Contains factors II, VII, IX, and X; protein C; and trace amounts of heparin to guard against thrombosis. The dose can be calculated depending on the concentration of protein C in a preparation. Preparations may vary.

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