Factor XI Deficiency Differential Diagnoses

Updated: Jun 15, 2022
  • Author: Jamie E Siegel, MD; Chief Editor: Srikanth Nagalla, MD, MS, FACP  more...
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Diagnostic Considerations

The differential diagnosis in patients with isolated prolongation of the activated partial thromboplastin time (aPTT) includes the following:

  • Factor VIII deficiency
  • Factor IX deficiency
  • Factor XI deficiency
  • Factor XII deficiency
  • Lupus anticoagulant
  • Heparin contamination

The differential diagnosis in patients with a mild or intermittent bleeding disorder includes the following:

  • Von Willebrand disease
  • Factor VIII deficiency/carrier state
  • Factor IX deficiency/carrier state
  • Factor VII deficiency (mild)
  • Platelet function disorder
  • Early liver dysfunction