Kikuchi Disease Treatment & Management

1. Masab M, Farooq H. Kikuchi Disease. Clin Rheumatol. 2017 Jun. 27(8):1073-5. [Medline]. [Full Text].

2. Bosch X, Guilabert A, Miquel R, Campo E. Enigmatic Kikuchi-Fujimoto disease: a comprehensive review. Am J Clin Pathol. 2004 Jul. 122(1):141-52. [Medline].

3. Alam H, Saeed MO, Saeed AB, Zaidi A. Kikuchi disease. J Pak Med Assoc. 2015 Dec. 65 (12):1349-50. [Medline].

4. Lamzaf L, Harmouche H, Maamar M, Adnaoui M, Aouni M, Tazi Mezalek Z. Kikuchi-Fujimoto disease: report of 4 cases and review of the literature. Eur Ann Otorhinolaryngol Head Neck Dis. 2014 Dec. 131 (6):329-32. [Medline].

5. Kuo TT. Kikuchi's disease (histiocytic necrotizing lymphadenitis). A clinicopathologic study of 79 cases with an analysis of histologic subtypes, immunohistology, and DNA ploidy. Am J Surg Pathol. 1995 Jul. 19(7):798-809. [Medline].

6. Dorfman RF, Berry GJ. Kikuchi's histiocytic necrotizing lymphadenitis: an analysis of 108 cases with emphasis on differential diagnosis. Semin Diagn Pathol. 1988 Nov. 5(4):329-45. [Medline].

7. Gallien S, Lagrange-Xelot M, Crabol Y, et al. [Systemic lupus erythematosus and Kikuchi-Fujimoto disease mimicking tuberculosis] [French]. Med Mal Infect. 2008 Jun 17. epub ahead of print. [Medline].

8. Yilmaz M, Camci C, Sari I, et al. Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto's disease) mimicking systemic lupus erythematosus: a review of two cases. Lupus. 2006. 15(6):384-7. [Medline].

9. Poulose V, Chiam P, Poh WT. Kikuchi's disease: a Singapore case series. Singapore Med J. 2005 May. 46(5):229-32. [Medline]. [Full Text].

10. Scagni P, Peisino MG, Bianchi M, et al. Kikuchi-Fujimoto disease is a rare cause of lymphadenopathy and fever of unknown origin in children: report of two cases and review of the literature. J Pediatr Hematol Oncol. 2005 Jun. 27(6):337-40. [Medline].

11. Hedia G, Jamel A, Maher A, et al. Kikuchi-Fujimoto disease associated with systemic lupus erythematosus. J Clin Rheumatol. 2005 Dec. 11(6):341-2. [Medline].

12. Dumas G, Prendki V, Haroche J, Amoura Z, Cacoub P, et al. Kikuchi-Fujimoto disease: retrospective study of 91 cases and review of the literature. Medicine (Baltimore). 2014 Nov. 93 (24):372-82. [Medline]. [Full Text].

13. Spies J, Foucar K, Thompson CT, LeBoit PE. The histopathology of cutaneous lesions of Kikuchi's disease (necrotizing lymphadenitis): a report of five cases. Am J Surg Pathol. 1999 Sep. 23(9):1040-7. [Medline].

14. Sierra ML, Vegas E, Blanco-González JE, et al. Kikuchi's disease with multisystemic involvement and adverse reaction to drugs. Pediatrics. 1999 Aug. 104(2):e24. [Medline]. [Full Text].

15. Lee S, Yoo JH, Lee SW. Kikuchi Disease: Differentiation from Tuberculous Lymphadenitis Based on Patterns of Nodal Necrosis on CT. AJNR Am J Neuroradiol. 2011 Dec 15. [Medline].

16. Găman M, Vlădăreanu AM, Dobrea C, Onisâi M, Marinescu C, Voican I, et al. A Challenging Case of Kikuchi-Fujimoto Disease Associated with Systemic Lupus Erythematosus and Review of the Literature. Case Rep Hematol. 2018. 2018:1791627. [Medline]. [Full Text].

17. Hutchinson CB, Wang E. Kikuchi-Fujimoto disease. Arch Pathol Lab Med. 2010 Feb. 134(2):289-93. [Medline].

18. Supari D, Ananthamurthy A. Kikuchi-fujimoto disease: a study of 24 cases. Indian J Otolaryngol Head Neck Surg. 2014 Jan. 66(1):69-73. [Medline]. [Full Text].

19. Sopeña B, Rivera A, Vázquez-Triñanes C, Fluiters E, González-Carreró J, Del Pozo M, et al. Autoimmune Manifestations of Kikuchi Disease. Semin Arthritis Rheum. 2011 Dec 20. [Medline].

20. Lee EJ, Lee HS, Park JE, Hwang JS. Association Kikuchi disease with Hashimoto thyroiditis: a case report and literature review. Ann Pediatr Endocrinol Metab. 2018 Jun. 23 (2):99-102. [Medline]. [Full Text].

21. Hudnall SD. Kikuchi-Fujimoto disease. Is Epstein-Barr virus the culprit?. Am J Clin Pathol. 2000 Jun. 113(6):761-4. [Medline]. [Full Text].

22. Barbat B, Jhaj R, Khurram D. Fatality in Kikuchi-Fujimoto disease: A rare phenomenon. World J Clin Cases. 2017 Feb 16. 5 (2):35-39. [Medline]. [Full Text].

23. Shim EJ, Lee KM, Kim EJ, Kim HG, Jang JH. CT pattern analysis of necrotizing and nonnecrotizing lymph nodes in Kikuchi disease. PLoS One. 2017. 12 (7):e0181169. [Medline]. [Full Text].

24. Jung IY, Ann HW, Kim JJ, Lee SJ, Kim J, Seong H, et al. The incidence and clinical characteristics by gender differences in patients with Kikuchi-Fujimoto disease. Medicine (Baltimore). 2017 Mar. 96 (11):e6332. [Medline]. [Full Text].

25. Kang HM, Kim JY, Choi EH, Lee HJ, Yun KW, Lee H. Clinical Characteristics of Severe Histiocytic Necrotizing Lymphadenitis (Kikuchi-Fujimoto Disease) in Children. J Pediatr. 2016 Feb 4. [Medline].

26. Atwater AR, Longley BJ, Aughenbaugh WD. Kikuchi's disease: case report and systematic review of cutaneous and histopathologic presentations. J Am Acad Dermatol. 2008 Jul. 59(1):130-6. [Medline].

27. Yasukawa K, Matsumura T, Sato-Matsumura KC, et al. Kikuchi's disease and the skin: case report and review of the literature. Br J Dermatol. 2001 Apr. 144(4):885-9. [Medline].

28. Khishfe BF, Krass LM, Nordquist EK. Kikuchi disease presenting with aseptic meningitis. Am J Emerg Med. 2014 Oct. 32 (10):1298.e1-2. [Medline].

29. Singh YP, Agarwal V, Krishnani N, Misra R. Enthesitis-related arthritis in Kikuchi-Fujimoto disease. Mod Rheumatol. 2008 May 10. epub ahead of print. [Medline].

30. Tong TR, Chan OW, Lee KC. Diagnosing Kikuchi disease on fine needle aspiration biopsy: a retrospective study of 44 cases diagnosed by cytology and 8 by histopathology. Acta Cytol. 2001 Nov-Dec. 45(6):953-7. [Medline].

31. Viguer JM, Jiménez-Heffernan JA, Pérez P, et al. Fine-needle aspiration cytology of Kikuchi's lymphadenitis: a report of ten cases. Diagn Cytopathol. 2001 Oct. 25(4):220-4. [Medline].

32. Kwon SY, Kim TK, Kim YS, et al. CT findings in Kikuchi disease: analysis of 96 cases. AJNR Am J Neuroradiol. 2004 Jun-Jul. 25(6):1099-102. [Medline]. [Full Text].

33. Kato H, Kanematsu M, Kato Z, Teramoto T, Kondo N, Hirose Y, et al. MR imaging findings of cervical lymphadenopathy in patients with Kikuchi disease. Eur J Radiol. 2011 Dec. 80 (3):e576-81. [Medline].

34. Ryoo I, Suh S, Lee YH, Seo HS, Seol HY. Comparison of Ultrasonographic Findings of Biopsy-Proven Tuberculous Lymphadenitis and Kikuchi Disease. Korean J Radiol. 2015 Jul-Aug. 16 (4):767-75. [Medline]. [Full Text].

35. Tabata T, Takata K, Miyata-Takata T, Sato Y, Ishizawa S, Kunitomo T, et al. Characteristic Distribution Pattern of CD30-positive Cytotoxic T Cells Aids Diagnosis of Kikuchi-Fujimoto Disease. Appl Immunohistochem Mol Morphol. 2018 Apr. 26 (4):274-282. [Medline].

36. Jang YJ, Park KH, Seok HJ. Management of Kikuchi's disease using glucocorticoid. J Laryngol Otol. 2000 Sep. 114(9):709-11. [Medline].

37. Hyun M, So IT, Kim HA, Jung H, Ryu SY. Recurrent Kikuchi's Disease Treated by Hydroxychloroquine. Infect Chemother. 2016 Jun. 48 (2):127-31. [Medline].

38. Kishimoto K, Tate G, Kitamura T, Kojima M, Mitsuya T. Cytologic features and frequency of plasmacytoid dendritic cells in the lymph nodes of patients with histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease). Diagn Cytopathol. 2009 Nov 25. epub ahead of print. [Medline].

John Boone, MD Consulting Staff, Department of Otolaryngology, Naval Hospital Oak Harbor

John Boone, MD is a member of the following medical societies: American Academy of Otolaryngology-Head and Neck Surgery

Disclosure: Nothing to disclose.

Charles S Kuzma, MD Consulting Staff, Clinical Research Coordinator, First Health of the Carolinas Cancer Center

Charles S Kuzma, MD is a member of the following medical societies: American College of Physicians, American Society of Hematology, California Medical Association

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Lawrence H Brent, MD Associate Professor of Medicine, Sidney Kimmel Medical College of Thomas Jefferson University; Chair, Program Director, Department of Medicine, Division of Rheumatology, Albert Einstein Medical Center

Lawrence H Brent, MD is a member of the following medical societies: American Association for the Advancement of Science, American Association of Immunologists, American College of Physicians, American College of Rheumatology

Disclosure: Stock ownership for: Johnson & Johnson.

Koyamangalath Krishnan, MD, FRCP, FACP Dishner Endowed Chair of Excellence in Medicine, Professor of Medicine, James H Quillen College of Medicine at East Tennessee State University

Koyamangalath Krishnan, MD, FRCP, FACP is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians-American Society of Internal Medicine, American Society of Hematology, Royal College of Physicians

Disclosure: Nothing to disclose.

Karen Seiter, MD Professor, Department of Internal Medicine, Division of Oncology/Hematology, New York Medical College

Karen Seiter, MD is a member of the following medical societies: American Association for Cancer Research, American College of Physicians, American Society of Hematology

Disclosure: Received honoraria from Novartis for speaking and teaching; Received consulting fee from Novartis for speaking and teaching; Received honoraria from Celgene for speaking and teaching.

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