Hereditary and Acquired Hypercoagulability Follow-up

Updated: Jul 12, 2021
  • Author: Manojna Konda, MD; Chief Editor: Srikanth Nagalla, MD, MS, FACP  more...
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If a patient is known to have a lupus anticoagulant or a thrombophilia, it is important to avoid oral contraceptives and hormone replacement therapy. Also, prophylactic anticoagulation should be considered in patients with additional risk for venous thrombosis, such as immobilization or surgery.

The risk of venous thrombosis is considerably greater in patients with two hereditary thrombophilias or with a thrombophilia and an acquired hypercoagulable disorder. Prophylactic anticoagulation should be considered in these circumstances.



The risk of thrombosis in a person with hypercoagulability varies with the underlying condition (see Overview/Epidemiology). The prognosis is probably worse in patients with antithrombin III deficiency and lupus anticoagulants than in those without those factors.