Acquired Hemophilia Questions & Answers

Updated: Jan 10, 2020
  • Author: Sara J Grethlein, MD, FACP; Chief Editor: Srikanth Nagalla, MD, MS, FACP  more...
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Questions & Answers

Overview

What causes acquired hemophilia?

What are the signs and symptoms of acquired hemophilia?

What is included in the workup of acquired hemophilia?

How is acquired hemophilia treated?

What is acquired hemophilia?

How is acquired hemophilia diagnosed?

What are the strategies for treatment of acquired hemophilia?

What is the pathophysiology of acquired hemophilia?

Which disorders associated with acquired hemophilia have inhibitors to coagulation factors other than FVIII?

Which conditions are associated with acquired hemophilia?

What are the underlying diagnoses of acquired hemophilia A?

What is the prevalence of acquired hemophilia?

What is the global prevalence of acquired hemophilia?

Which patient groups have the highest prevalence of acquired hemophilia?

What is the prognosis of acquired hemophilia?

What is included in patient education about acquired hemophilia?

Presentation

Which clinical history findings are characteristic of acquired hemophilia?

Which physical findings are characteristic of acquired hemophilia?

What are the possible complications of acquired hemophilia?

DDX

Which conditions are included in the differential diagnoses of acquired hemophilia?

What are the differential diagnoses for Acquired Hemophilia?

Workup

Which lab test results are characteristic of acquired hemophilia?

What is the role of aPTT in the workup of acquired hemophilia?

How is the presence of lupus anticoagulant assessed in the workup of acquired hemophilia?

How is the presence of heparin assessed in the workup of acquired hemophilia?

What is the role of coagulation factor assays in the workup of acquired hemophilia?

What is the role of imaging studies in the workup of acquired hemophilia?

Which test are performed in women with pregnancy-associated acquired hemophilia?

Treatment

What are the goals for treatment of acquired hemophilia?

Which activity modifications are used in the treatment of acquired hemophilia?

How are bleeding episodes treated in acquired hemophilia?

How is acquired hemophilia treated in patients with low levels of inhibitors?

How is acquired hemophilia treated in patients with high levels of inhibitors?

What is the role of porcine sequence recombinant FVIII in the treatment of acquired hemophilia?

What is the role of recombinant factor VII in the treatment of acquired hemophilia?

What is the role of APCC in the treatment of acquired hemophilia?

What is the role of combination therapy in the treatment of acquired hemophilia?

What is the role of immunoadsorption or plasmapheresis in the treatment of acquired hemophilia?

How are inhibitors eradicated in the treatment of acquired hemophilia?

What is the role of steroids in the treatment of acquired hemophilia?

What is the role of biologic therapy in the treatment of acquired hemophilia?

What is the role of cyclosporine in the treatment of acquired hemophilia?

What is the role of IVIG in the treatment of acquired hemophilia?

What is the role of immune tolerance induction regimens in the treatment of acquired hemophilia?

What is the role of emicizumab in the treatment of acquired hemophilia?

What is the role of surgery in the treatment of acquired hemophilia?

How is acquired hemophilia treated in elderly patients?

How is acquired hemophilia treated in patients with an underlying malignancy?

What can trigger severe bleeding in patients with acquired hemophilia?

Which specialist consultations are beneficial to patients with acquired hemophilia?

Medications

What is the role of medications in the treatment of acquired hemophilia?

Which medications in the drug class Monoclonal Antibodies are used in the treatment of Acquired Hemophilia?

Which medications in the drug class Immunosuppressive Agents are used in the treatment of Acquired Hemophilia?

Which medications in the drug class Corticosteroids are used in the treatment of Acquired Hemophilia?

Which medications in the drug class Antihemophilic Agents are used in the treatment of Acquired Hemophilia?

Which medications in the drug class Antihemophilic Agent, Hemostatic Agent, Vasopressin Analog, Synthetic­ are used in the treatment of Acquired Hemophilia?

Which medications in the drug class Coagulation Factors are used in the treatment of Acquired Hemophilia?