Adenovirus Questions & Answers

1. Kopecky-Bromberg SA, Palese P. Recombinant vectors as influenza vaccines. Curr Top Microbiol Immunol. 2009. 333:243-67. [QxMD MEDLINE Link].

2. Harvey AR, Hellström M, Rodger J. Gene therapy and transplantation in the retinofugal pathway. Prog Brain Res. 2009. 175:151-61. [QxMD MEDLINE Link].

3. Limbach KJ, Richie TL. Viral vectors in malaria vaccine development. Parasite Immunol. 2009 Sep. 31(9):501-19. [QxMD MEDLINE Link].

4. Vora GJ, Lin B, Gratwick K et al. Co-infections of adenovirus species in previously vaccinated patients. Emerg Infect Dis. June 2006. 12:921-30. [QxMD MEDLINE Link].

5. Echavarría M. Adenoviruses in immunocompromised hosts. Clin Microbiol Rev. 2008 Oct. 21(4):704-15. [QxMD MEDLINE Link]. [Full Text].

6. Shah KV. SV40 and human cancer: a review of recent data. Int J Cancer. 2007 Jan 15. 120(2):215-23. [QxMD MEDLINE Link].

7. Martini F, Corallini A, Balatti V, Sabbioni S, Pancaldi C, Tognon M. Simian virus 40 in humans. Infect Agent Cancer. 2007. 2:13. [QxMD MEDLINE Link].

8. Solomon ET, Gari SR, Kloos H, Alemu BM. Handwashing effect on diarrheal incidence in children under 5 years old in rural eastern Ethiopia: a cluster randomized controlled trial. Trop Med Health. 2021 Mar 23. 49(1):26. [QxMD MEDLINE Link]. [Full Text].

9. Luby SP, Agboatwalla M, Painter J, Altaf A, Billhimer W, Keswick B, et al. Combining drinking water treatment and hand washing for diarrhoea prevention, a cluster randomised controlled trial. Trop Med Int Health. 2006 Apr. 11(4):479-89. [QxMD MEDLINE Link]. [Full Text].

10. Killerby ME, Rozwadowski F, Lu X, Caulcrick-Grimes M, McHugh L, Haldeman AM, et al. Respiratory Illness Associated With Emergent Human Adenovirus Genome Type 7d, New Jersey, 2016-2017. Open Forum Infect Dis. 2019 Jan 11. ofz017. [QxMD MEDLINE Link]. [Full Text].

11. Kujawski SA, Lu X, Schneider E, Blythe D, Boktor S, Farrehi J, et al. Outbreaks of adenovirus-associated respiratory illness on five college campuses in the United States. Clin Infect Dis. 2020 Apr 23. ciaa465. [QxMD MEDLINE Link]. [Full Text].

12. Tabain I, Ljubin-Sternak S, Cepin-Bogovic J, Markovinovic L, Knezovic I, Mlinaric-Galinovic G. Adenovirus Respiratory Infections in Hospitalized Children: Clinical Findings in Relation to Species and Serotypes. Pediatr Infect Dis J. 2012 Apr 18. [QxMD MEDLINE Link].

13. Faden H, Wynn RJ, Campagna L, Ryan RM. Outbreak of adenovirus type 30 in a neonatal intensive care unit. J Pediatr. 2005 Apr. 146(4):523-7. [QxMD MEDLINE Link].

14. Kajon AE, Moseley JM, Metzgar D, Huong HS, Wadleigh A, Ryan MA. Molecular epidemiology of adenovirus type 4 infections in US military recruits in the postvaccination era (1997-2003). J Infect Dis. 2007 Jul 1. 196(1):67-75. [QxMD MEDLINE Link].

15. Russell KL, Hawksworth AW, Ryan MA et al. Vaccine-preventable adenoviral respiratory illness in US military recruits,1999-2004. Vaccine. April 2006. 15:2835-42. [QxMD MEDLINE Link].

16. Wirsing von König CH, Rott H, Bogaerts H, Schmitt HJ. A serologic study of organisms possibly associated with pertussis-like coughing. Pediatr Infect Dis J. 1998 Jul. 17(7):645-9. [QxMD MEDLINE Link].

17. Versteegh FG, Mooi-Kokenberg EA, Schellekens JF, Roord JJ. Bordetella pertussis and mixed infections. Minerva Pediatr. 2006 Apr. 58(2):131-7. [QxMD MEDLINE Link].

18. Saiki-Macedo S, Valverde-Ezeta J, Cornejo-Tapia A, Castillo ME, Petrozzi-Helasvuo V, Aguilar-Luis MA, et al. Identfication of viral and bacterial etiologic agents of the pertussis-like syndrome in children under 5 years old hospitalized. BMC Infect Dis. 2019 Jan 21. 19(1):75. [QxMD MEDLINE Link]. [Full Text].

19. Dart JK, El-Amir AN, Maddison T, Desai P, Verma S, Hughes A, et al. Identification and control of nosocomial adenovirus keratoconjunctivitis in an ophthalmic department. Br J Ophthalmol. 2009 Jan. 93(1):18-20. [QxMD MEDLINE Link].

20. Bruno B, Zager RA, Boeckh MJ, et al. Adenovirus nephritis in hematopoietic stem-cell transplantation. Transplantation. 2004 Apr 15. 77(7):1049-57. [QxMD MEDLINE Link].

21. Nakamura Y, Ohashi K, Nakano N, Nemoto T, Funada N, Ando M. [Acute necrotizing tubulointerstitial nephritis due to adenoviral infection following hematopoietic stem cell transplantation: clinical findings obtained from 4 autopsy cases]. Nippon Jinzo Gakkai Shi. 2008. 50(8):1036-43. [QxMD MEDLINE Link].

22. Uhnoo I, Wadell G, Svensson L, Johansson ME. Importance of enteric adenoviruses 40 and 41 in acute gastroenteritis in infants and young children. J Clin Microbiol. 1984 Sep. 20(3):365-72. [QxMD MEDLINE Link]. [Full Text].

23. Jalal H, Bibby DF, Tang JW, Bennett J, Kyriakou C, Peggs K. First reported outbreak of diarrhea due to adenovirus infection in a hematology unit for adults. J Clin Microbiol. 2005 Jun. 43(6):2575-80. [QxMD MEDLINE Link].

24. Munoz FM, Piedra PA, Demmler GJ. Disseminated adenovirus disease in immunocompromised and immunocompetent children. Clin Infect Dis. 1998 Nov. 27(5):1194-1200. [QxMD MEDLINE Link]. [Full Text].

25. Ison MG. Adenovirus infections in transplant recipients. Clin Infect Dis. 2006 Aug 1. 43(3):331-9. [QxMD MEDLINE Link].

26. Hedderwick SA, Greenson JK, McGaughy VR, Clark NM. Adenovirus cholecystitis in a patient with AIDS. Clin Infect Dis. 1998 Apr. 26(4):997-9. [QxMD MEDLINE Link].

27. Liu M, Worley S, Arrigain S, Aurora P, Ballmann M, Boyer D, et al. Respiratory viral infections within one year after pediatric lung transplant. Transpl Infect Dis. 2009 Aug. 11(4):304-12. [QxMD MEDLINE Link].

28. Echavarria M, Sanchez JL, Kolavic-Gray SA, Polyak CS, Mitchell-Raymundo F, Innis BL, et al. Rapid detection of adenovirus in throat swab specimens by PCR during respiratory disease outbreaks among military recruits. J Clin Microbiol. 2003 Feb. 41(2):810-2. [QxMD MEDLINE Link].

29. Lu X, Trujillo-Lopez E, Lott L, Erdman DD. Quantitative real-time PCR assay panel for detection and type-specific identification of epidemic respiratory human adenoviruses. J Clin Microbiol. 2013 Apr. 51(4):1089-93. [QxMD MEDLINE Link]. [Full Text].

30. Lion T, Baumgartinger R, Watzinger F, Matthes-Martin S, Suda M, Preuner S, et al. Molecular monitoring of adenovirus in peripheral blood after allogeneic bone marrow transplantation permits early diagnosis of disseminated disease. Blood. 2003 Aug 1. 102(3):1114-20. [QxMD MEDLINE Link]. [Full Text].

31. Marchiori E, Escuissato DL, Gasparetto TD, Considera DP, Franquet T. "Crazy-paving" patterns on high-resolution CT scans in patients with pulmonary complications after hematopoietic stem cell transplantation. Korean J Radiol. 2009 Jan-Feb. 10(1):21-4. [QxMD MEDLINE Link]. [Full Text].

32. Lion T. Adenovirus infections in immunocompetent and immunocompromised patients. Clin Microbiol Rev. 2014. 27(3):441-462. [QxMD MEDLINE Link]. [Full Text].

33. Matthes-Martin S, Feuchtinger T, Shaw PJ, Engelhard D, Hirsch HH, Cordonnier C, et al. Fourth European Conference on Infections in Leukemia. European guidelines for diagnosis and treatment of adenovirus infection in leukemia and stem cell transplantation: summary of ECIL-4 (2011). Transpl Infect Dis. 2012 Dec. 14(6):Epub. [QxMD MEDLINE Link]. [Full Text].

34. Humar A, Kumar D, Mazzulli T, Razonable RR, Moussa G, Paya CV, et al. A surveillance study of adenovirus infection in adult solid organ transplant recipients. Am J Transplant. 2005 Oct. 5 (10):2555-9. [QxMD MEDLINE Link].

35. Faiyumi MA, Betensley A. Successful Treatment of Severe Adenovirus Pneumonia With Cidofovir in a Lung Transplant Recipient. Chest. 2013. 144:172A-172B.

36. Feuchtinger T, Lücke J, Hamprecht K, Richard C, Handgretinger R, Schumm M. Detection of adenovirus-specific T cells in children with adenovirus infection after allogeneic stem cell transplantation. Br J Haematol. 2005 Feb. 128(4):503-9. [QxMD MEDLINE Link].

37. Wy Ip W, Qasim W. Management of adenovirus in children after allogeneic hematopoietic stem cell transplantation. Adv Hematol. 2013. 2013:176418. [QxMD MEDLINE Link]. [Full Text].

38. Creidy R, Moshous D, Touzot F, et al. Specific T cells for the treatment of cytomegalovirus and/or adenovirus in the context of hematopoietic stem cell transplantation. J Allergy Clin Immunol. 2016 Sep. 138 (3):920-924.e3. [QxMD MEDLINE Link].

39. Horlock C, Skulte A, Mitra A, Stansfield A, Bhandari S, Ip W, et al. Manufacture of GMP-compliant functional adenovirus-specific T-cell therapy for treatment of post-transplant infectious complications. Cytotherapy. 2016 Sep. 18 (9):1209-18. [QxMD MEDLINE Link].

40. Barrett AJ, Prockop S, Bollard CM. Virus-Specific T Cells: Broadening Applicability. Biol Blood Marrow Transplant. 2018 Jan. 24 (1):13-18. [QxMD MEDLINE Link].

41. Carter BA, Karpen SJ, Quiros-Tejeira RE, et al. Intravenous Cidofovir therapy for disseminated adenovirus in a pediatric liver transplant recipient. Transplantation. 2002 Oct 15. 74(7):1050-2. [QxMD MEDLINE Link].

42. Hayashi M, Lee C, de Magalhaes-Silverman M. Adenovirus infections in BMT patients successfully treated with cidofovir. Blood. 2000. 96 (suppl 1):189a.

43. Muller WJ, Levin MJ, Shin YK, Robinson C, Quinones R, Malcolm J. Clinical and in vitro evaluation of cidofovir for treatment of adenovirus infection in pediatric hematopoietic stem cell transplant recipients. Clin Infect Dis. 2005 Dec 15. 41(12):1812-6. [QxMD MEDLINE Link].

44. Neofytos D, Ojha A, Mookerjee B, Wagner J, Filicko J, Ferber A, et al. Treatment of adenovirus disease in stem cell transplant recipients with cidofovir. Biol Blood Marrow Transplant. 2007 Jan. 13(1):74-81. [QxMD MEDLINE Link].

45. Yusuf U, Hale GA, Carr J, Gu Z, Benaim E, Woodard P. Cidofovir for the treatment of adenoviral infection in pediatric hematopoietic stem cell transplant patients. Transplantation. 2006 May 27. 81(10):1398-404. [QxMD MEDLINE Link].

46. Saquib R, Melton LB, Chandrakantan A, Rice KM, Spak CW, Saad RD, et al. Disseminated adenovirus infection in renal transplant recipients: the role of cidofovir and intravenous immunoglobulin. Transpl Infect Dis. 2009 Sep 15. [QxMD MEDLINE Link].

47. Sofer A, Arger N, Vest M. Successful Treatment of Adenovirus-Induced ARDS With Cidofovir and IVIG. Chest. 2013. 144:229A-229B.

48. Prasad VK, Papanicolaou GA, Maron GM et al. Treatment of Adenovirus (AdV) Infection in Allogeneic Hematopoietic Cell Transplant (allo HCT) Patients (pts) with Brincidofovir: Final 36 Week Results from the AdVise Tria. Biology of Blood and Marrow Transplantation. 2017. 23:S57–S58.

49. Brundage TM, Vainorius E, Chittick G et al. Brincidofovir Decreases Adenovirus Viral Burden, Which is Associated with Improved Mortality in Pediatric Allogeneic Hematopoietic Cell Transplant Recipients. Biology of Blood and Marrow Transplantation. 2018. 24:S372.

50. Grimley MS, Chemaly RF, Englund JA, Kurtzberg J, Chittick G, Brundage TM, et al. Brincidofovir for Asymptomatic Adenovirus Viremia in Pediatric and Adult Allogeneic Hematopoietic Cell Transplant Recipients: A Randomized Placebo-Controlled Phase II Trial. Biol Blood Marrow Transplant. 2017 Mar. 23 (3):512-521. [QxMD MEDLINE Link].

51. Chimerix, Inc. Expanded Access. Chimerix.com. Available at https://www.chimerix.com/patient-resources/expanded-access/#. Accessed: 13 April 2021.

52. Romanowski EG, Hussein ITM, Cardinale SC, Butler MM, Morin LR, Bowlin TL, et al. Filociclovir Is an Active Antiviral Agent against Ocular Adenovirus Isolates In Vitro and in the Ad5/NZW Rabbit Ocular Model. Pharmaceuticals (Basel). 2021 Mar 26. 14(4):294. [QxMD MEDLINE Link]. [Full Text].

53. Barraza EM, Ludwig SL, Gaydos JC et al. Reemergence of adenovirus type 4 acute respiratory disease in military trainees:report of an outbreak during a lapse in vaccination. J Infect Dis. June 1999. 179:1531-3. [QxMD MEDLINE Link].

54. Ryan MA, Gray GC, Smith B, et al. Large epidemic of respiratory illness due to adenovirus types 7 and 3 in healthy young adults. Clin Infect Dis. 2002 Mar 1. 34(5):577-82. [QxMD MEDLINE Link].

55. Vora GJ, Lin B, Gratwick K et al. o-infections of adenovirus species in previously vaccinated patients. Emerg Infect Dis. June 2006. 12:921-30. [QxMD MEDLINE Link].

56. Rutala WA, Peacock JE, Gergen MF, Sobsey MD, Weber DJ. Efficacy of hospital germicides against adenovirus 8, a common cause of epidemic keratoconjunctivitis in health care facilities. Antimicrob Agents Chemother. 2006 Apr. 50 (4):1419-24. [QxMD MEDLINE Link].

57. Fanourgiakis P, Georgala A, Vekemans M, Triffet A, De Bruyn JM, Duchateau V. Intravesical instillation of cidofovir in the treatment of hemorrhagic cystitis caused by adenovirus type 11 in a bone marrow transplant recipient. Clin Infect Dis. 2005 Jan 1. 40(1):199-201. [QxMD MEDLINE Link].

Sandra G Gompf, MD, FACP, FIDSA Professor of Infectious Disease and International Medicine, University of South Florida Morsani College of Medicine; Chief, Infectious Diseases Section, Director, Occupational Health and Infection Control Programs, James A Haley Veterans Hospital

Sandra G Gompf, MD, FACP, FIDSA is a member of the following medical societies: American College of Physicians, Infectious Diseases Society of America

Disclosure: Nothing to disclose.

Tuhina Cornelius, MD, MBBS Fellow in Infectious Disease, Florida Department of Health, University of South Florida Morsani College of Medicine

Tuhina Cornelius, MD, MBBS is a member of the following medical societies: American College of Physicians

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Richard B Brown, MD, FACP Chief, Division of Infectious Diseases, Baystate Medical Center; Professor, Department of Internal Medicine, Tufts University School of Medicine

Richard B Brown, MD, FACP is a member of the following medical societies: Alpha Omega Alpha, American College of Chest Physicians, American College of Physicians, American Medical Association, American Society for Microbiology, Infectious Diseases Society of America, Massachusetts Medical Society

Disclosure: Nothing to disclose.

Michael Stuart Bronze, MD David Ross Boyd Professor and Chairman, Department of Medicine, Stewart G Wolf Endowed Chair in Internal Medicine, Department of Medicine, University of Oklahoma Health Science Center; Master of the American College of Physicians; Fellow, Infectious Diseases Society of America; Fellow of the Royal College of Physicians, London

Michael Stuart Bronze, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians, American Medical Association, Association of Professors of Medicine, Infectious Diseases Society of America, Oklahoma State Medical Association, Southern Society for Clinical Investigation

Disclosure: Nothing to disclose.

David Hall Shepp, MD Program Director, Fellowship in Infectious Diseases, Department of Medicine, North Shore University Hospital; Associate Professor, New York University School of Medicine

David Hall Shepp, MD is a member of the following medical societies: Infectious Diseases Society of America

Disclosure: Received salary from Gilead Sciences for management position.

Richard Oehler, MD Associate Professor, Department of Internal Medicine, Division of Infectious Diseases and International Medicine, University of South Florida College of Medicine; Director of Clinical Education, Division of Infectious Diseases, Tampa Veterans Affairs Medical Center

Richard Oehler, MD is a member of the following medical societies: American College of Physicians, American Medical Association, Infectious Diseases Society of America, Society for Healthcare Epidemiology of America

Disclosure: Nothing to disclose.

Dhanashree Kelkar, MD Lecturer, Department of Medicine, Dr Vasantrao Pawar Medical College, Maharashtra University of Health Sciences, India

Dhanashree Kelkar, MD is a member of the following medical societies: American Medical Association, American Association of Physicians of Indian Origin

Disclosure: Nothing to disclose.

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