Cutaneous T-Cell Lymphoma Questions & Answers

Updated: Aug 15, 2018
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Questions & Answers

Overview

What is cutaneous T-cell lymphoma (CTCL)?

What are the signs and symptoms of Sézary syndrome cutaneous T-cell lymphoma (CTCL)?

How is Sézary syndrome cutaneous T-cell lymphoma (CTCL) treated?

What are the WHO classifications for cutaneous T-cell lymphoma (CTCL)?

Which types of cutaneous T-cell lymphoma (CTCL) have indolent clinical behavior?

Which types of cutaneous T-cell lymphoma (CTCL) have aggressive clinical behavior?

What are the stages of classic mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

How is mycosis fungoides cutaneous T-cell lymphoma (CTCL) diagnosed?

Which lab tests are indicated in the workup of mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

What are the diagnostic criteria for Sézary syndrome cutaneous T-cell lymphoma (CTCL)?

Which imaging studies are indicated in the workup of cutaneous T-cell lymphoma (CTCL)?

Which staging system is used for the mycosis fungoides and Sézary syndrome types of cutaneous T-cell lymphoma (CTCL)?

How is early stage cutaneous T-cell lymphoma (CTCL) treated?

How is mycosis fungoides cutaneous T-cell lymphoma (CTCL) treated?

What topical therapies are available for mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

Which medications are used in the management of cutaneous T-cell lymphoma (CTCL)?

What is the historical background for cutaneous T-cell lymphoma (CTCL)?

How is primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma characterized?

How common is mycosis fungoides cutaneous T-cell lymphoma (CTCL) and how is it characterized?

What is the prevalence of Sézary syndrome in cutaneous T-cell lymphoma (CTCL)?

How are cutaneous T-cell lymphomas (CTCL) classified?

What is primary cutaneous CD30-positive lymphoproliferative disorder in cutaneous T-cell lymphoma (CTCL)?

What are the manifestations of cutaneous T-cell anaplastic large cell lymphoma (ALCL)?

How is CD30-positive primary cutaneous T cell lymphoproliferative disorder distinguished from systemic anaplastic large cell lymphoma (ALCL)?

What is the workup for staging primary cutaneous CD30-positive lymphoproliferative disorder in cutaneous T-cell lymphoma (CTCL)?

What is the manifestation of lymphomatoid papulosis cutaneous T-cell lymphoma (CTCL)?

How is subcutaneous panniculitis-like T-cell lymphoma characterized?

What are the histologic findings in subcutaneous panniculitis-like T-cell lymphoma?

What are the immunologic findings of subcutaneous panniculitis-like T-cell lymphoma?

What are the types of subcutaneous panniculitis-like T-cell lymphoma?

How is the presentation of primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma characterized?

What are the aggressive subtypes of cutaneous T-cell lymphoma (CTCL)?

How is adult cutaneous T-cell lymphoma (CTCL) characterized?

How is nasal-type extranodal NK/T-cell lymphoma characterized?

How is primary cutaneous peripheral T-cell lymphoma, unspecified (PTCL-U) characterized?

What is the historical background of mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

What are the race-related demographics of mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

What are the variants of mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

How does folliculotropic mycosis fungoides cutaneous T-cell lymphoma (CTCL) manifest?

How does pagetoid reticulosis cutaneous T-cell lymphoma (CTCL) manifest?

How does granulomatous slack skin cutaneous T-cell lymphoma (CTCL) manifest?

What is the patient education for cutaneous T-cell lymphoma (CTCL)?

What is the pathophysiology of cutaneous T-cell lymphoma (CTCL)?

What is the pathophysiology of mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

What causes cutaneous T-cell lymphoma (CTCL)?

What environmental factors play a role in the etiology of cutaneous T-cell lymphoma (CTCL)?

What is the prevalence of cutaneous T-cell lymphoma (CTCL)?

What are the race-related demographics of cutaneous T-cell lymphoma (CTCL)?

Is cutaneous T-cell lymphoma (CTCL) more common in men or women?

Which age groups are most commonly affected by cutaneous T-cell lymphoma (CTCL)?

What is the mortality and prognosis of cutaneous T-cell lymphoma (CTCL)?

What are prognostic factors of cutaneous T-cell lymphoma (CTCL)?

Which factors are associated with poor outcomes in cutaneous T-cell lymphoma (CTCL)?

What is the prognosis of Sézary syndrome cutaneous T-cell lymphoma (CTCL)?

What is the prognosis of folliculotropic mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

What is the prognosis of adult T-cell leukemia/lymphoma?

What is the prognosis of subcutaneous panniculitis-like T-cell lymphoma?

What is the prognosis of unilesional pagetoid reticulosis cutaneous T-cell lymphoma (CTCL)?

What is the prognosis of primary cutaneous peripheral T-cell lymphoma, unspecified (PTCL-U)?

What is the prognosis of nasal-type NK/T-cell lymphoma?

What is the prognosis of granulomatous cutaneous T-cell lymphomas (CTCL)?

What is the prognosis of the provisional entities of cutaneous T-cell lymphoma (CTCL)?

What are potential complications of mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

Presentation

What is the clinical history of hypopigmented mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

What is the clinical history of bullous mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

What is the clinical history of cutaneous T-cell lymphoma (CTCL)?

What is the clinical history of classic mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

What is the clinical history of stages IA and IB mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

What is the clinical history of stages IIA and IIB mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

What is the clinical history of D'emblee mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

What is the clinical history of stage III mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

What is the clinical history of stages IVA and IVB mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

What is the clinical history large cell transformation of mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

What is the clinical history of pagetoid reticulosis cutaneous T-cell lymphoma (CTCL)?

What is the clinical history of folliculotropic mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

What is the clinical history of pustular mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

What is the clinical history of hyperpigmented fungoides cutaneous T-cell lymphoma (CTCL)?

What is the clinical history of unilesional mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

What is the clinical history of syringotropic mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

What is the clinical history of poikilodermatous mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

What is the clinical history of granulomatous slack skin syndrome in cutaneous T-cell lymphoma (CTCL)?

What are additional variants and characteristics of the mycosis fungoides type of cutaneous T-cell lymphoma (CTCL)?

What is the clinical history of Sézary syndrome in cutaneous T-cell lymphoma (CTCL)?

How is erythroderma characterized in Sézary syndrome cutaneous T-cell lymphoma (CTCL)?

What are the signs of cutaneous T-cell lymphoma (CTCL)?

How are patches and plaques characterized in cutaneous T-cell lymphoma (CTCL)?

What are the physical findings of skin tumors in cutaneous T-cell lymphoma (CTCL)?

What are the physical findings of lymphadenopathy in cutaneous T-cell lymphoma (CTCL)?

What are the physical findings of granulomatous slack skin syndrome in cutaneous T-cell lymphoma (CTCL)?

What are the physical findings of acute adult T-cell leukemia/lymphoma?

What are the physical findings of subcutaneous panniculitis-like T-cell lymphoma?

What are the physical findings of primary cutaneous peripheral T-cell lymphoma?

What are the physical findings of primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma?

What are the physical findings of primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma?

What are the physical findings of nasal-type extranodal NK/T-cell lymphoma?

DDX

What are the diagnostic considerations in the workup of cutaneous T-cell lymphoma (CTCL)?

What are the differential diagnoses for Cutaneous T-Cell Lymphoma?

Workup

What are the approach considerations in the workup of mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

What are the diagnostic criteria for Sézary syndrome in cutaneous T-cell lymphoma (CTCL)?

Which lab tests are indicated in the workup of mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

What is the role of reflectance confocal microscopy in the workup of cutaneous T-cell lymphoma (CTCL)?

Which imaging studies are indicated in the workup of cutaneous T-cell lymphoma (CTCL)?

What is the role of polymerase chain reaction (PCR) assay in the workup of cutaneous T-cell lymphoma (CTCL)?

What is the role of genetic testing in the workup of cutaneous T-cell lymphoma (CTCL)?

What is the role of genetic testing in the workup of mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

What are the genetic features of cutaneous T-cell lymphoma (CTCL)?

When is biopsy indicated in the workup of cutaneous T-cell lymphoma (CTCL)?

What are the biopsy findings in cutaneous T-cell lymphoma (CTCL)?

What are the histologic findings of mycosis fungoides in cutaneous T-cell lymphoma (CTCL)?

What are the histologic findings of primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma?

What are the histologic criteria for a diagnosis of mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

How are the histologic findings in mycosis fungoides plaques characterized in cutaneous T-cell lymphoma (CTCL)?

What are the histologic findings of folliculotropic mycosis fungoides in cutaneous T-cell lymphoma (CTCL)?

What are the histologic findings of granulomatous mycosis fungoides in cutaneous T-cell lymphoma (CTCL)?

What are the histologic findings of pagetoid reticulosis in cutaneous T-cell lymphoma (CTCL)?

What are the histologic findings of Sézary syndrome in cutaneous T-cell lymphoma (CTCL)?

What are the histologic findings of adult T-cell leukemia/lymphoma in cutaneous T-cell lymphoma (CTCL)?

What are the histologic findings of subcutaneous panniculitis-like T-cell lymphoma?

What are the histologic findings of cutaneous gamma/delta-positive T-cell lymphoma?

What are the histologic findings of primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma?

What are the histologic findings of nasal-type extranodal NK/T-cell lymphoma?

What are the histologic findings of primary cutaneous peripheral T-cell lymphoma?

What are the stages of mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

Treatment

What are the approach considerations in the treatment of cutaneous T-cell lymphoma (CTCL)?

How is localized mycosis fungoides cutaneous T-cell lymphoma (CTCL) treated?

How effective is the treatment of localized mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

What is the role of extracorporeal photopheresis in the treatment of cutaneous T-cell lymphoma (CTCL)?

What is the role of cord blood transplantation in the treatment of cutaneous T-cell lymphoma (CTCL)?

What is the role of bone marrow transplantation in the treatment of cutaneous T-cell lymphoma (CTCL)?

What is the role of combination chemotherapy in the treatment of cutaneous T-cell lymphoma (CTCL)?

Which specialist consultations are indicated in the treatment of cutaneous T-cell lymphoma (CTCL)?

What topical therapies are indicated in the treatment of cutaneous T-cell lymphoma (CTCL)?

How effective is topical therapy for the treatment of cutaneous T-cell lymphoma (CTCL)?

What topical agents are available for the treatment of cutaneous T-cell lymphoma (CTCL)?

What systemic treatments are used in the management of cutaneous T-cell lymphoma (CTCL)?

What skin-targeted therapies are used in the treatment of cutaneous T-cell lymphoma (CTCL)?

What are the benefits of bexarotene or alemtuzumab in the treatment of cutaneous T-cell lymphoma (CTCL)?

What is the role of methotrexate in the treatment of cutaneous T-cell lymphoma (CTCL)?

How effective is total skin electron beam therapy for the treatment of stages T1 and T2 mycosis fungoides in cutaneous T-cell lymphoma (CTCL)?

What is the role of tazarotene, etoposide, or imiquimod in the treatment of early cutaneous T-cell lymphoma (CTCL)?

Which biologic agents are used in the treatment of cutaneous T-cell lymphoma (CTCL)?

When is multiagent chemotherapy indicated in the treatment of cutaneous T-cell lymphoma (CTCL)?

Which medications are indicated in the treatment of subcutaneous panniculitis-like T cell lymphoma?

How is Sézary syndrome cutaneous T-cell lymphoma (CTCL) treated?

How is follicular mycosis fungoides cutaneous T-cell lymphoma (CTCL) treated?

Guidelines

What are the classifications of cutaneous T-cell lymphoma (CTCL)?

What are the classification schemas for non-Hodgkin lymphoma (NHL) and cutaneous T-cell lymphoma (CTCL)?

When were consensus guidelines released for the treatment of mycosis fungoides and Sezary syndrome (MF/SS) in cutaneous T-cell lymphoma (CTCL)?

Which studies are recommended to establish a diagnosis of mycosis fungoides/Sezary syndrome (MF/SS) in cutaneous T-cell lymphoma (CTCL)?

What is the tumor-node-metastasis-blood (TNMB) classification of mycosis fungoides/Sezary syndrome (MF/SS) in cutaneous T-cell lymphoma (CTCL)?

What are the treatment guidelines for mycosis fungoides/Sezary syndrome (MF/SS) in cutaneous T-cell lymphoma (CTCL)?

What is the recommended treatment for mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

What are the recommended localized therapies for mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

What are the recommended systemic therapies for mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

What are the recommended therapies for advanced mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

What is the role of participation in a clinical trial in the treatment of Sezary syndrome and erythrodermic mycosis fungoides cutaneous T-cell lymphoma (CTCL)?

Which organizations are represented in the joint consensus recommendations for the management of primary cutaneous CD30+ T-Cell lymphoproliferative disorders (CD30+LPDs)?

What is the classifications of primary cutaneous CD30+ T-Cell lymphoproliferative disorders (CD30+LPDs)?

What are the recommended diagnostic criteria for primary cutaneous CD30+ T-cell lymphoproliferative disorders (CD30+LPDs)?

What are the stages of primary cutaneous CD30+ T-Cell lymphoproliferative disorders (CD30+LPDs)?

What are the treatment recommendations for primary cutaneous CD30+ T-Cell lymphoproliferative disorders (CD30+LPDs)?

Medications

What is the drug treatment for cutaneous T-cell lymphoma (CTCL)?

What are the novel therapies for cutaneous T-cell lymphoma (CTCL)?

Which medications in the drug class Corticosteroids are used in the treatment of Cutaneous T-Cell Lymphoma?

Which medications in the drug class Retinoid-like Agents are used in the treatment of Cutaneous T-Cell Lymphoma?

Which medications in the drug class Topical Skin Products are used in the treatment of Cutaneous T-Cell Lymphoma?

Which medications in the drug class Antineoplastics, Monoclonal Antibody are used in the treatment of Cutaneous T-Cell Lymphoma?

Which medications in the drug class Immunomodulators are used in the treatment of Cutaneous T-Cell Lymphoma?

Which medications in the drug class Antineoplastics, Other are used in the treatment of Cutaneous T-Cell Lymphoma?