Cryptosporidiosis Differential Diagnoses

Updated: Jan 13, 2022
  • Author: Maria A Caravedo, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Diagnostic Considerations

Many laboratories do not routinely test for Cryptosporidium, and the tests used for the organism are insensitive in many cases. [1]  However, failure to consider Cryptosporidium as the cause of diarrhea, particularly in cases with prolonged symptoms, may result in expensive diagnostic tests and consultations.

Rotavirus enteritis is one disorder to consider in the differential diagnosis of cryptosporidiosis. Other pathogens to consider include the following:

  • Giardia lamblia
  • Microsporidia
  • Cyclospora cayetanensis
  • Clostridium difficile


Campylobacter Infections

Cyclospora Infection (Cyclosporiasis)

Escherichia coli (E coli) Infections



Salmonella Infection (Salmonellosis)


Viral Gastroenteritis

Differential Diagnoses