Diphyllobothriasis Medication

Updated: Jun 13, 2019
  • Author: David R Haburchak, MD, FACP; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Medication Summary

The goals of pharmacotherapy are to eradicate the infection, to reduce morbidity, and to prevent complications.



Class Summary

Antimicrobial agents are used to eradicate the infecting organism (most often, D latum). Praziquantel is the drug of choice; niclosamide is an alternative.

Niclosamide (Niclocide)

DOC; inhibits mitochondrial oxidative phosphorylation and glucose uptake in the parasite.

Praziquantel (Biltricide)

Praziquantel is used in the treatment of several different infestations and is the drug of choice for diphyllobothriasis. It increases cell membrane permeability in susceptible worms, resulting in loss of intracellular calcium, massive contractions, and paralysis of musculature. Tablets should be swallowed with liquid during meals; keeping the tablets in the mouth may result in a bitter taste that can induce nausea or vomiting.