Therapeutic Drug Levels 

Updated: Jul 31, 2015
  • Author: Abimbola Farinde, PharmD, PhD; more...
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Therapeutic Drug Levels

Table 1. Therapeutic Drug Levels [1] (Open Table in a new window)

Drug

Therapeutic Range

Acetaminophen

10-25 μg/mL

Amikacin

Nonbacteremic gram-negative infection (urinary tract infection, synergism with beta-lactams): 15-30 μg/mL Serious gram-negative infection (bacteremia, pneumonia, sepsis): 25-40 μg/mL

Amitriptyline

120-150 ng/mL

Carbamazepine

4-12 μg/mL

Chloramphenicol

Meningitis: 15-25 μg/mL Other infections: 10-20 μg/mL  

Desipramine

100-300 ng/mL

Digoxin

0.8-2 ng/mL

Disopyramide

2-4 μg/mL

Ethosuximide

40-100 μg/mL

Flecainide

Adults: 0.2-1 μg/mL Children: 0.2-0.8 μg/mL

Gentamicin

5-10 μg/mL

Imipramine

150-250 ng/mL

Kanamycin

15-30 μg/mL

Lidocaine

1.5-5 μg/mL

Lithium

Relapse prevention for bipolar disorder: 0.6-1 mEq/L Acute mania: 0.8-1.2 mEq/L Elderly patients: 0.4-0.8 mEq/L

Methotrexate

High-dose regimens result in 0.1-1 μmol/L 24-72 h postinfusion Toxic levels: >0.2 μmol/L (low-dose); >1 μmol/L (high-dose)

Nortriptyline

50-150 ng/mL

Phenobarbital

Adults: 10-40 μg/mL Infants/children: 15-30 μg/mL

Phenytoin

Total phenytoin levels: 10-20 μg/mL

Primidone

5-12 μg/mL

Procainamide

Procainamide: 4-8 μg/mL N-acetylprocainamide: 4-8 μg/mL

Quinidine

2-5 μg/mL

Salicylate

Antiplatelet/analgesia/antipyretic: ~100 μg/mL Mild toxic effects observed with anti-inflammatory dose levels of 150-300 μg/mL

Sirolimus

5-15 μg/L (whole blood)

Tacrolimus

5-20 μg/L (whole blood)

Theophylline

Adults: 5-15 μg/mL Children: 5-10 μg/mL Neonatal apnea: 6-11 μg/mL

Tobramycin

Life-threatening infection: 8-10 μg/mL Serious infection: 6-8 μg/mL Urinary tract infection: 4-6 μg/mL Synergy for infections caused by gram-positive organisms: 3-5 μg/mL

Valproic acid

Epilepsy (total): 50-100 μg/mL Mania (total): 50-125 μg/mL Free: 6-22 μg/mL

Cyclosporine

50-125 microgram/L (serum or plasma) 150-400microgram/L (whole blood)