Cardiovascular disease (high severity rating [H])
Antiarrhythmic drugs (class Ia, Ic, III): Avoid as first-line agents for atrial fibrillation[1, 2, 3, 4]
Disopyramide
Dronedarone
Digoxin >0.125 mg/day[1]
High-sodium-content drugs
Hypertension (H)
Phenylpropanolamine hydrochloride
Pseudoephedrine
Diet pills
Amphetamines
Gastric/duodenal ulcer disease (H)
Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, aspirin >325 mg, diclofenac, etodolac, ibuprofen)
Non–cox-2–selective NSAIDs
Indomethacin
Ketorolac, including parenteral
Seizures or epilepsy (H)
Bupropion
Clozapine
Chlorpromazine
Olanzapine
Thioridazine
Thiothixene
Tramadol
Blood clotting disorders or anticoagulation therapy (H)
Aspirin
NSAIDS
Dabigatran
Dipyridamole
Ticlopidine
Clopidogrel
Prasugrel
Bladder outflow obstruction (H)
Anticholinergics/antispasmodic
Oral antimuscarinics (eg, oxybutynin, darifenacin, solifenacin)
First-generation antihistamines (eg, diphenhydramine, chlorpheniramine, cyproheptadine)
Gastrointestinal antispasmodics
Muscle relaxants
Oxybutynin
Flavoxate
Antidepressants
Decongestants
Tolterodine
Stress incontinence (H)
Alpha blockers
Anticholinergics
Tricyclic antidepressants
Long-acting benzodiazepines
Arrhythmias (H)
Tricyclic antidepressants
Insomnia (H)
Oral decongestants
Theophylline
Methylphenidate
Monoamine oxidase inhibitors (MAOIs)
Amphetamines
Parkinson disease (H)
Antiemetics (eg, metoclopramide, promethazine)
Conventional antipsychotics
Tacrine
Cognitive impairment (H)
Barbiturates
Anticholinergics
Antispasmodics
Muscle relaxants
CNS stimulants
H2 receptor antagonist
Antipsychotics (as needed and long-term use)
Depression (H)
Long-term benzodiazepines
Sympatholytic agents
Anorexia and malnutrition (H)
CNS stimulants
Syncope or falls (H)
Short- to intermediate-acting benzodiazepines
Tricyclic antidepressants
Syndrome of inappropriate antidiuretic hormone secretion/hyponatremia (low severity rating [L])
Selective serotonin reuptake inhibitors (SSRIs)
Carbamazepine
Antipsychotics
Obesity (L)
Olanzapine
Chronic obstructive pulmonary disease (H)
Long-acting benzodiazepines
Beta-blockers
Chronic constipation (L)
Nondihydropyridine calcium channel blockers (eg, diltiazem and verapamil)
Anticholinergics/antispasmodics
Tricyclic antidepressants