These agents inhibit the rate-limiting step in cholesterol biosynthesis by competitively inhibiting HMG-CoA reductase.[1, 2, 3] Note the following:
Vitamin B3 inhibits very-low-density lipoprotein (VLDL) synthesis. Note the following:
Fibrates enhance lipoprotein lipase, resulting in increased VLDL catabolism, fatty acid oxidation, and triglyceride elimination. They decrease hepatic extraction of free fatty acids. Note the following:
These agents inhibit sterol transporter at brush border and, consequently, intestinal absorption of cholesterol.
These agents lower cholesterol and LDL via bile duct sequestration. Note the following:
These agents target messenger RNA for apolipoprotein B (apoB)–100, the principal apolipoprotein of LDL and its metabolic precursor, VLDL.[5] Note the following:
These agents directly bind and inhibit microsomal triglyceride transfer protein (MTP), thereby preventing ApoB-containing lipoproteins. Note the following:
Omega 3 acid agents inhibit acyl CoA:1,2-diacylglycerol acyltransferase. Note the following:
Inclisiran is a double-stranded small interfering RNA conjugated on sense strand with triantennary N-acetylgalactosamine to facilitate uptake by hepatocytes. In hepatocytes, inclisiran utilizes the RNA interference mechanism and directs catalytic breakdown of mRNA for proprotein convertase subtilisin kexin type 9 (PCSK9). This increases LDL-C receptor recycling and expression on the hepatocyte cell surface, which increases LDL-C uptake and lowers LDL-C levels in the circulation.
These combination drugs lower lipids:
Overview
What is the role of omega 3 acids in the regulation of lipids?
What is the role of statins in the regulation of lipids?
What is the role of vitamin B3 in the regulation of lipids?
What is the role of fibrates in the regulation of lipids?
What is the role of ezetimibe in the regulation of lipids?
What is the role of bile acid sequestrants in the regulation of lipids?
What is the role of mipomersen in the regulation of lipids?
What is the role of lomitapid in the regulation of lipids?
Which combination drugs are used to lower lipids?