Iron Study Interpretation 

Updated: Dec 04, 2018
Author: Buck Christensen; Chief Editor: Buck Christensen 

Iron Study Interpretation

Increases in serum iron level are associated with the following:[1, 2, 3]

  • Idiopathic hemochromatosis

  • Liver necrosis (viral hepatitis)

  • Hemosiderosis caused by excessive iron intake (eg, multiple transfusions, excess iron administration)

  • Acute iron poisoning (children)

  • Hemolytic anemia

  • Pernicious anemia

  • Aplastic or hypoplastic anemia

  • Lead poisoning

  • Thalassemia

  • Vitamin B6 deficiency

  • Estrogens

  • Ethanol

  • Oral contraceptive

Decreases in the serum iron level are associated with the following:[1, 2, 3]

  • Iron deficiency anemia

  • Nephrotic syndrome(loss of iron-binding proteins)

  • Iron deficiency

  • Chronic renal failure

  • Many infections

  • Active hematopoiesis

  • Remission of pernicious anemia

  • Hypothyroidism

  • Malignancy (carcinoma)

  • Postoperative state

  • Kwashiorkor

Table 1. Microcytic Anemias (Open Table in a new window)

 

Ferritin

Serum Iron

Total Iron Binding Capacity

Iron deficiency anemia

Low

Low

High

Anemia of chronic disease

High

Low

Low

Sideroblastic anemia

High

High

Normal

Thalassemia

Normal

Normal

Normal