Effects of Various Vasopressors
Epinephrine [1]
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Receptors: Moderate beta-2, strong beta-1 and alpha adrenergic
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Increased cardiac output (CO) and heart rate (HR)
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Decreased renal perfusion
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Increased pulmonary vascular resistance (PVR), minimally
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Increased systemic vascular resistance (SVR)
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Significant increase in systolic function
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No effect in diastolic function
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Increased oxygen demand, significantly
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Variable blood pressure (BP)
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Receptors: Strong alpha-1 and alpha-2, moderate beta-1
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Increased PVR, minimally
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Increased BP
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Increased SVR, significantly
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No effect on diastolic function
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Increased oxygen demand
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Increased systolic function, minimally
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Decreased renal perfusion
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Variable CO
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Receptors: Strong alpha-1
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Increased SVR, significantly
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No effect on PVR
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Increased BP
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No effect on HR
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No effect on systolic or diastolic function
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No effect on myocardial oxygen demand
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Decreased CO and renal perfusion
Dopamine, low dose (1-5 µg/kg/min)
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Receptors: Dopaminergic agonist
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Renal and mesenteric vasodilation
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Increased HR
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Increased systolic function, minimal
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No effect in diastolic function
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Increased oxygen demand, minimal
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Increased SVR, minimal
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No effect on PVR
Dopamine, medium dose (6-10 µg/kg/min)
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Receptors: Beta-1 agonist
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Increased systolic function
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Increased HR and CO
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No effect in diastolic function
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Increased myocardial oxygen demand
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Increased SVR
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Increased PVR, minimal
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Renal vasodilation
Dopamine, large dose (11-20 µg/kg/min)
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Receptors: Alpha-1 agonist
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Increased HR, CO, PVR
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No effect on diastolic function
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Increased myocardial oxygen demand
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Increased PVR, minimal
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Increased SVR, significantly
Dobutamine [3]
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Receptors: Strong beta-1, weak beta-2 and alpha receptors
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Increased HR, CO
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Increased HR
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Increased systolic function
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No effect on diastolic function
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Increased in myocardial oxygen demand
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Decreased SVR
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Decreased PVR, minimally
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Receptors: ADH analogue
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PVR effect unknown
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Increased SVR, significantly
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No effect on HR
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No effect on systolic or diastolic function
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No effect in myocardial oxygen demand
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Splanchnic vasoconstriction