Autoimmune Antibodies

Antinuclear antibodies and the conditions with which they are associated include the following ^[1] :

• Anti-centromere antibodies: Limited cutaneous systemic sclerosis (CREST syndrome), primary biliary cirrhosis, proximal scleroderma

• Anti-dsDNA: Systemic lupus erythematosus (SLE)

• Anti-gp210: Primary biliary cirrhosis

• Anti-histone antibodies: SLE and drug-induced lupus erythematosus (LE)

• Anti-Jo1: Polymyositis, dermatomyositis

• Anti-La/SS-B autoantibodies: Primary Sjögren syndrome ^[2]

• Anti-p62: Primary biliary cirrhosis

• Anti-PM-Scl: Polymyositis/systemic sclerosis (PM/SSc) overlap syndrome

• Anti-RNP: Mixed connective-tissue disease, SLE

• Anti-Ro/SS-A autoantibodies: Systemic lupus erythematosus (SLE), primary Sjögren syndrome, neonatal heart block

• Anti-Sm (Smith): SLE

• Anti-sp100: Primary biliary cirrhosis

• Anti-topoisomerase antibodies: Scleroderma

Other autoantibodies and associated diseases include the following:

• Anti-CCP: Rheumatoid arthritis

• Anti-ganglioside antibodies: Miller-Fisher syndrome, acute motor axonal neuropathy, multifocal motor neuropathy with conduction block

• Anti-mitochondrial antibody: Primary biliary cirrhosis

• Antiphospholipid antibodies: Antiphospholipid syndrome

• Anti-smooth muscle antibody: Chronic autoimmune hepatitis ^[3]

• Anti-SRP: Polymyositis

• Anti-thyroid autoantibodies: Hashimoto thyroiditis, Graves disease

• Anti-transglutaminase antibodies: Celiac disease, dermatitis herpetiformis

• c-ANCA: Wegener granulomatosis

• Liver kidney microsomal type 1 antibody: Autoimmune hepatitis ^[4]

• Lupus anticoagulant: SLE

• p-ANCA: Wegener granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome, systemic vasculitides

• Rheumatoid factor: Rheumatoid arthritis