Autoantibodies
Antinuclear antibodies and the conditions with which they are associated include the following: [1]
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Anti-centromere antibodies: Limited cutaneous systemic sclerosis (CREST syndrome), primary biliary cirrhosis, proximal scleroderma
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Anti-dsDNA: Systemic lupus erythematosus (SLE)
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Anti-gp210: Primary biliary cirrhosis
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Anti-histone antibodies: SLE and drug-induced lupus erythematosus (LE)
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Anti-Jo1: Polymyositis, dermatomyositis
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Anti-La/SS-B autoantibodies: Primary Sjögren syndrome [2]
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Anti-p62: Primary biliary cirrhosis
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Anti-PM-Scl: Polymyositis/systemic sclerosis (PM/SSc) overlap syndrome
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Anti-RNP: Mixed connective-tissue disease, SLE
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Anti-Ro/SS-A autoantibodies: Systemic lupus erythematosus (SLE), primary Sjögren syndrome, neonatal heart block
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Anti-Sm (Smith): SLE
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Anti-sp100: Primary biliary cirrhosis
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Anti-topoisomerase antibodies: Scleroderma
Other autoantibodies and associated diseases include the following:
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Anti-CCP: Rheumatoid arthritis
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Anti-ganglioside antibodies: Miller-Fisher syndrome, acute motor axonal neuropathy, multifocal motor neuropathy with conduction block
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Anti-mitochondrial antibody: Primary biliary cirrhosis
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Antiphospholipid antibodies: Antiphospholipid syndrome
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Anti-smooth muscle antibody: Chronic autoimmune hepatitis [3]
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Anti-SRP: Polymyositis
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Anti-thyroid autoantibodies: Hashimoto thyroiditis, Graves disease
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Anti-transglutaminase antibodies: Celiac disease, dermatitis herpetiformis
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c-ANCA: Wegener granulomatosis
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Liver kidney microsomal type 1 antibody: Autoimmune hepatitis [4]
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Lupus anticoagulant: SLE
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p-ANCA: Wegener granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome, systemic vasculitides
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Rheumatoid factor: Rheumatoid arthritis
