Autoimmune Antibodies 

Updated: Nov 24, 2014
Author: Buck Christensen; Chief Editor: Buck Christensen 

Autoantibodies

Antinuclear antibodies and the conditions with which they are associated include the following:[1]

  • Anti-centromere antibodies: Limited cutaneous systemic sclerosis (CREST syndrome), primary biliary cirrhosis, proximal scleroderma

  • Anti-dsDNA: Systemic lupus erythematosus (SLE)

  • Anti-gp210: Primary biliary cirrhosis

  • Anti-histone antibodies: SLE and drug-induced lupus erythematosus (LE)

  • Anti-Jo1: Polymyositis, dermatomyositis

  • Anti-La/SS-B autoantibodies: Primary Sjögren syndrome

  • Anti-p62: Primary biliary cirrhosis

  • Anti-PM-Scl: Polymyositis/systemic sclerosis (PM/SSc) overlap syndrome

  • Anti-RNP: Mixed connective-tissue disease, SLE

  • Anti-Ro/SS-A autoantibodies: Systemic lupus erythematosus (SLE), primary Sjögren syndrome, neonatal heart block

  • Anti-Sm (Smith): SLE

  • Anti-sp100: Primary biliary cirrhosis

  • Anti-topoisomerase antibodies: Scleroderma

Other autoantibodies and associated diseases include the following:

  • Anti-CCP: Rheumatoid arthritis

  • Anti-ganglioside antibodies: Miller-Fisher syndrome, acute motor axonal neuropathy, multifocal motor neuropathy with conduction block

  • Anti-mitochondrial antibody: Primary biliary cirrhosis

  • Antiphospholipid antibodies: Antiphospholipid syndrome

  • Anti-smooth muscle antibody: Chronic autoimmune hepatitis

  • Anti-SRP: Polymyositis

  • Anti-thyroid autoantibodies: Hashimoto thyroiditis, Graves disease

  • Anti-transglutaminase antibodies: Celiac disease, dermatitis herpetiformis

  • c-ANCA: Wegener granulomatosis

  • Liver kidney microsomal type 1 antibody: Autoimmune hepatitis

  • Lupus anticoagulant: SLE

  • p-ANCA: Wegener granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome, systemic vasculitides

  • Rheumatoid factor: Rheumatoid arthritis