Benzodiazepine Equivalency Table 

Updated: Jul 31, 2018
  • Author: Abimbola Farinde, PharmD, PhD; more...
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Benzodiazepine Equivalency

Evidence-based information on benzodiazepine equivalency is limited, and different sources may disagree; hence the use of dose ranges in this table. Even so, the data listed in this table are estimates, and their use requires clinical judgement.

Particularly when tapering a dose, a very gradual reduction with attention to patient response is required. This is particularly the case for patients who have been taking benzodiazepines for an extended period of time. When escalating a dose, it is preferable to err on the side of caution, to avoid overshooting and causing respiratory depression.

Table 1. Benzodiazepine Equivalency [1, 2, 3, 4] (Open Table in a new window)

 

Approximately Equivalent Oral Doses, mg

Time to Peak Level, hours

Half-life, hours

Alprazolam (Xanax)

0.5–1

1-2

12

Bromazepam (Lexotan)*

3–6

1-4

20

Chlordiazepoxide (Librium)

10–25

1-4

100

Clonazepam (Klonopin)

0.25–0.5

1-4

34

Clorazepate (Tranxene)

7.5–15

0.5-2

100

Diazepam (Valium)

5–10

1-2

100

Flurazepam (Dalmane)

15–30

0.5-1

100

Lorazepam (Ativan)

1–2

1-4

15

Nitrazepam (Mogadon)*

2.5–10

0.5-2

30

Oxazepam (Serax)

15–30

1-4

8

Quazepam (Doral)

10–20

1.5

25-41

Temazepam (Restoril)

10–20

2-3

11

Triazolam (Halcion)

0.25–0.5

1-2

2

*Not available in the United States

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