Lumbosacral Spondylolisthesis Medication

Updated: Apr 22, 2020
  • Author: Adam E Perrin, MD, FAAFP; Chief Editor: Craig C Young, MD  more...
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Medication Summary

The goals of pharmacotherapy are to reduce morbidity and to prevent complications.


Nonsteroidal Anti-inflammatory Drugs

Class Summary

Nonsteroidal anti-inflammatory drugs (NSAIDs) have analgesic, anti-inflammatory, and antipyretic activities. The mechanism of action of these agents is not known, but NSAIDs may inhibit cyclooxygenase activity and prostaglandin synthesis. Other mechanisms may include leukotriene synthesis inhibition, lysosomal enzyme release, lipoxygenase activity, neutrophil aggregation and various cell membrane functions.

Ibuprofen (Motrin, Ibuprin)

Ibuprofen is available in both prescription and nonprescription strength.


Nonnarcotic Analgesics

Class Summary

Nonnarcotic analgesics are used for control of pain but not inflammation. These drugs are not associated with any adverse gastrointestinal (GI) reactions (ie, gastritis, peptic ulcer disease).

Acetaminophen (Tylenol, Feverall, Tempra, Aspirin-Free Anacin)

Acetaminophen is the drug of choice for pain in patients with documented hypersensitivity to aspirin or NSAIDs, with upper GI disease, or who are taking oral anticoagulants.