Haemophilus Influenzae Infections Questions & Answers

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8. Langereis JD, de Jonge MI. Unraveling Haemophilus influenzae virulence mechanisms enable discovery of new targets for antimicrobials and vaccines. Curr Opin Infect Dis. 2020 Jun. 33 (3):231-237. [QxMD MEDLINE Link].

9. Kaufhold I, Osbahr S, Shima K, Marwitz S, Rohmann K, Drömann D, et al. Nontypeable Haemophilus influenzae (NTHi) directly interfere with the regulation of E-cadherin in lung epithelial cells. Microbes Infect. 2017 Aug 10. [QxMD MEDLINE Link].

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15. Mahapatra T. Vaccine coverage estimation using Global Positioning System and Google Earth: A commentary. Ann Trop Med Public Health. June 22, 2017. 10:295-6. [Full Text].

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17. MacNeil JR, Cohn AC, Farley M, Mair R, Baumbach J, Bennett N, et al. Current epidemiology and trends in invasive Haemophilus influenzae disease--United States, 1989-2008. Clin Infect Dis. 2011 Dec. 53(12):1230-6. [QxMD MEDLINE Link].

18. Ortiz-Romero MDM, Espejo-García MP, Alfayate-Miguelez S, Ruiz-López FJ, Zapata-Hernandez D, Gonzalez-Pacanowska AJ, et al. Epidemiology of Nasopharyngeal Carriage by Haemophilus influenzae in Healthy Children: A Study in the Mediterranean Coast Region. Pediatr Infect Dis J. 2017 Oct. 36 (10):919-923. [QxMD MEDLINE Link].

19. Whittaker R, Economopoulou A, Dias JG, Bancroft E, Ramliden M, Celentano LP, et al. Epidemiology of Invasive Haemophilus influenzae Disease, Europe, 2007-2014. Emerg Infect Dis. 2017 Mar. 23 (3):396-404. [QxMD MEDLINE Link].

20. Giufrè M, Cardines R, Brigante G, Orecchioni F, Cerquetti M. Emergence of Invasive Haemophilus influenzae Type A Disease in Italy. Clin Infect Dis. 2017 Jun 1. 64 (11):1626-1628. [QxMD MEDLINE Link].

21. Tsang RS, Proulx JF, Hayden K, Shuel M, Lefebvre B, Boisvert AA, et al. Characteristics of invasive Haemophilus influenzae serotype a (Hia) from Nunavik, Canada and comparison with Hia strains in other North American Arctic regions. Int J Infect Dis. 2017 Apr. 57:104-107. [QxMD MEDLINE Link].

22. Szabo BG, Lenart KS, Tirczka T, Ostorhazi E. Clinical and microbiological characteristics of adult invasive Haemophilus influenzae infections: results of a 14-year single-center experience from Hungary. Infection. 2018 Dec. 46 (6):855-860. [QxMD MEDLINE Link].

23. von Gottberg A, Cohen C, Whitelaw A, Chhagan M, Flannery B, Cohen AL, et al. Invasive disease due to Haemophilus influenzae serotype b ten years after routine vaccination, South Africa, 2003-2009. Vaccine. 2011 Nov 26. [QxMD MEDLINE Link].

24. Dong Q, Shi W, Cheng X, Chen C, Meng Q, Yao K, et al. Widespread of non-typeable Haemophilus influenzae with high genetic diversity after two decades use of Hib vaccine in China. J Clin Lab Anal. 2020 Apr. 34 (4):e23145. [QxMD MEDLINE Link].

25. Tsang RSW, Ulanova M. The changing epidemiology of invasive Haemophilus influenzae disease: Emergence and global presence of serotype a strains that may require a new vaccine for control. Vaccine. 2017 Jul 24. 35 (33):4270-4275. [QxMD MEDLINE Link].

26. Singh V, Nanjappa S, Pabbathi S, Greene JN. Invasive Haemophilus influenzae Infection in Patients With Cancer. Cancer Control. 2017 Jan. 24 (1):66-71. [QxMD MEDLINE Link].

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29. Butler DF, Myers AL. Changing Epidemiology of Haemophilus influenzae in Children. Infect Dis Clin North Am. 2018 Mar. 32 (1):119-128. [QxMD MEDLINE Link].

30. Miyahara R, Suzuki M, Morimoto K, Chang B, Yoshida S, Yoshinaga S, et al. Nosocomial Outbreak of Upper Respiratory Tract Infection With β-Lactamase-Negative Ampicillin-Resistant Nontypeable Haemophilus influenzae. Infect Control Hosp Epidemiol. 2018 Jun. 39 (6):652-659. [QxMD MEDLINE Link].

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32. Cleland G, Leung C, Wan Sai Cheong J, Francis J, Heney C, Nourse C. Paediatric invasive Haemophilus influenzae in Queensland, Australia, 2002-2011: Young Indigenous children remain at highest risk. J Paediatr Child Health. 2017 Sep 4. [QxMD MEDLINE Link].

33. Gorga SM, Gilsdorf JR, Mychaliska KP. Haemophilus influenzae Serotype f Epiglottitis: A Case Report and Review. Hosp Pediatr. 2017 Jan. 7 (1):54-56. [QxMD MEDLINE Link].

34. Forstner C, Rohde G, Rupp J, Schuette H, Ott SR, Hagel S, et al. Community-acquired Haemophilus influenzae pneumonia--New insights from the CAPNETZ study. J Infect. 2016 May. 72 (5):554-63. [QxMD MEDLINE Link].

35. Walker WT, Jackson CL, Allan RN, Collins SA, Kelso MJ, Rineh A, et al. Primary ciliary dyskinesia ciliated airway cells show increased susceptibility to Haemophilus influenzae biofilm formation. Eur Respir J. 2017 Sep. 50 (3):[QxMD MEDLINE Link].

36. Shoemark A. Haemophilus influenzae; biofilms in primary ciliary dyskinesia: a moving story. Eur Respir J. 2017 Sep. 50 (3):[QxMD MEDLINE Link].

37. Sriram KB, Cox AJ, Clancy RL, Slack MPE, Cripps AW. Nontypeable Haemophilus influenzae and chronic obstructive pulmonary disease: a review for clinicians. Crit Rev Microbiol. 2017 May 25. 1-18. [QxMD MEDLINE Link].

38. Tan WS, Peh HY, Liao W, Pang CH, Chan TK, Lau SH, et al. Cigarette Smoke-Induced Lung Disease Predisposes to More Severe Infection with Nontypeable Haemophilus influenzae: Protective Effects of Andrographolide. J Nat Prod. 2016 May 27. 79 (5):1308-15. [QxMD MEDLINE Link].

39. Harris TM, Rumaseb A, Beissbarth J, Barzi F, Leach AJ, Smith-Vaughan HC. Culture of non-typeable Haemophilus influenzae from the nasopharynx: Not all media are equal. J Microbiol Methods. 2017 Jun. 137:3-5. [QxMD MEDLINE Link].

40. Roush SW, Murphy TV. Historical comparisons of morbidity and mortality for vaccine-preventable diseases in the United States. JAMA. 2007 Nov 14. 298(18):2155-63. [QxMD MEDLINE Link].

41. Price EP, Harris TM, Spargo J, Nosworthy E, Beissbarth J, Chang AB, et al. Simultaneous identification of Haemophilus influenzae and Haemophilus haemolyticus using real-time PCR. Future Microbiol. 2017 Jun. 12:585-593. [QxMD MEDLINE Link].

42. Bjarnason A, Lindh M, Westin J, Andersson LM, Baldursson O, Kristinsson KG, et al. Utility of oropharyngeal real-time PCR for S. pneumoniae and H. influenzae for diagnosis of pneumonia in adults. Eur J Clin Microbiol Infect Dis. 2017 Mar. 36 (3):529-536. [QxMD MEDLINE Link].

43. Dunne EM, Mantanitobua S, Singh SP, Reyburn R, Tuivaga E, Rafai E, et al. Real-time qPCR improves meningitis pathogen detection in invasive bacterial-vaccine preventable disease surveillance in Fiji. Sci Rep. 2016 Dec 23. 6:39784. [QxMD MEDLINE Link].

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48. Soysal A, Toprak DG, Türkoğlu S, Bakir M. Evaluation of the line probe assay for the rapid detection of bacterial meningitis pathogens in cerebrospinal fluid samples from children. BMC Microbiol. 2017 Jan 11. 17 (1):14. [QxMD MEDLINE Link].

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51. Bruin JP, Kostrzewa M, van der Ende A, Badoux P, Jansen R, Boers SA, et al. Identification of Haemophilus influenzae and Haemophilus haemolyticus by matrix-assisted laser desorption ionization-time of flight mass spectrometry. Eur J Clin Microbiol Infect Dis. 2014 Feb. 33 (2):279-84. [QxMD MEDLINE Link].

52. Zhu B, Xiao D, Zhang H, Zhang Y, Gao Y, Xu L, et al. MALDI-TOF MS distinctly differentiates nontypable Haemophilus influenzae from Haemophilus haemolyticus. PLoS One. 2013. 8 (2):e56139. [QxMD MEDLINE Link].

53. Månsson V, Gilsdorf JR, Kahlmeter G, Kilian M, Kroll JS, Riesbeck K, et al. Capsule Typing of Haemophilus influenzae by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry. Emerg Infect Dis. 2018 Mar. 24 (3):443-452. [QxMD MEDLINE Link].

54. Takeuchi N, Segawa S, Ishiwada N, Ohkusu M, Tsuchida S, Satoh M, et al. Capsular serotyping of Haemophilus influenzae by using matrix-associated laser desorption ionization-time of flight mass spectrometry. J Infect Chemother. 2018 Jul. 24 (7):510-514. [QxMD MEDLINE Link].

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56. Singleton R, Hammitt L, Hennessy T, et al. The Alaska Haemophilus influenzae type b experience: lessons in controlling a vaccine-preventable disease. Pediatrics. 2006 Aug. 118(2):e421-9. [QxMD MEDLINE Link].

57. Kiedrowska M, Kuch A, Żabicka D, Waśko I, Ronkiewicz P, Wasiak K, et al. Beta-lactam resistance among Haemophilus influenzae isolates in Poland. J Glob Antimicrob Resist. 2017 Aug 14. [QxMD MEDLINE Link].

58. Li JP, Hua CZ, Sun LY, Wang HJ, Chen ZM, Shang SQ. Epidemiological Features and Antibiotic Resistance Patterns of Haemophilus influenzae Originating from Respiratory Tract and Vaginal Specimens in Pediatric Patients. J Pediatr Adolesc Gynecol. 2017 Jun 16. [QxMD MEDLINE Link].

59. Maddi S, Kolsum U, Jackson S, Barraclough R, Maschera B, Simpson KD, et al. Ampicillin resistance in Haemophilus influenzae from COPD patients in the UK. Int J Chron Obstruct Pulmon Dis. 2017. 12:1507-1518. [QxMD MEDLINE Link].

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61. Tribuddharat C, Srifuengfung S. Multiple drug resistance in Haemophilus influenzae isolated from patients in Bangkok, Thailand. J Glob Antimicrob Resist. 2017 Jun. 9:121-123. [QxMD MEDLINE Link].

62. Deguchi T, Ito S, Hatazaki K, Horie K, Yasuda M, Nakane K, et al. Antimicrobial susceptibility of Haemophilus influenzae strains isolated from the urethra of men with acute urethritis and/or epididymitis. J Infect Chemother. 2017 Jun 12. [QxMD MEDLINE Link].

63. Wajima T, Seyama S, Nakamura Y, Kashima C, Nakaminami H, Ushio M, et al. Prevalence of macrolide-non-susceptible isolates among β-lactamase-negative ampicillin-resistant Haemophilus influenzae in a tertiary care hospital in Japan. J Glob Antimicrob Resist. 2016 Sep. 6:22-26. [QxMD MEDLINE Link].

64. Yamada S, Seyama S, Wajima T, Yuzawa Y, Saito M, Tanaka E, et al. β-Lactamase-non-producing ampicillin-resistant Haemophilus influenzae is acquiring multidrug resistance. J Infect Public Health. 2020 Apr. 13 (4):497-501. [QxMD MEDLINE Link].

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66. Kuo SC, Chen PC, Shiau YR, Wang HY, Lai JF 1st, Huang W, et al. Levofloxacin-resistant haemophilus influenzae, Taiwan, 2004-2010. Emerg Infect Dis. 2014 Aug. 20 (8):1386-90. [QxMD MEDLINE Link].

67. Chang CM, Shih HI, Wu CJ, Lauderdale TL, Lee NY, Lee CC, et al. Fluoroquinolone resistance in Haemophilus influenzae from nursing home residents in Taiwan: correlation of MICs and mutations in QRDRs. J Appl Microbiol. 2020 Jun. 128 (6):1624-1633. [QxMD MEDLINE Link].

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Joseph Adrian L Buensalido, MD Clinical Associate Professor, Division of Infectious Diseases, Department of Medicine, Philippine General Hospital, University of the Philippines Manila College of Medicine; Specialist in Infectious Diseases, Private Practice

Joseph Adrian L Buensalido, MD is a member of the following medical societies: American Society for Microbiology, Infectious Diseases Society of America, Michigan Infectious Disease Society, Philippine College of Physicians, Philippine Medical Association, Philippine Society for Microbiology and Infectious Diseases

Disclosure: Serve(d) as a speaker or a member of a speakers bureau for: Unilab; BSV Bioscience; Philcare Pharma<br/>Received sponsorship to medical conference for: Pfizer.

Anna Flor G Malundo, MD, FPCP Medical Specialist in STD/AIDS Guidance, Intervention and Prevention (SAGIP) Clinic, Section of Infectious Diseases, Department of Medicine, Philippine General Hospital, University of the Philippines Manila College of Medicine, Philippines

Anna Flor G Malundo, MD, FPCP is a member of the following medical societies: Philippine College of Physicians, Philippine Society for Microbiology and Infectious Diseases

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Charles V Sanders, MD Edgar Hull Professor and Chairman, Department of Internal Medicine, Professor of Microbiology, Immunology and Parasitology, Louisiana State University School of Medicine in New Orleans; Medical Director, Medicine Hospital Center, Charity Hospital and Medical Center of Louisiana at New Orleans; Consulting Staff, Ochsner Medical Center

Charles V Sanders, MD is a member of the following medical societies: Alliance for the Prudent Use of Antibiotics, Alpha Omega Alpha, American Association for Physician Leadership, American Association for the Advancement of Science, American Association of University Professors, American Clinical and Climatological Association, American College of Physicians, American Federation for Medical Research, American Geriatrics Society, American Lung Association, American Medical Association, American Society for Microbiology, American Thoracic Society, American Venereal Disease Association, Association for Professionals in Infection Control and Epidemiology, Association of American Medical Colleges, Association of American Physicians, Association of Professors of Medicine, Infectious Disease Society for Obstetrics and Gynecology, Infectious Diseases Society of America, Louisiana State Medical Society, Orleans Parish Medical Society, Royal Society of Medicine, Sigma Xi, The Scientific Research Honor Society, Society of General Internal Medicine, Southeastern Clinical Club, Southern Medical Association, Southern Society for Clinical Investigation, Southwestern Association of Clinical Microbiology, The Foundation for AIDS Research

Disclosure: Receives royalties from Baxter International for: Takeda-receives royalties; UpToDate-receives royalties.

Pranatharthi Haran Chandrasekar, MBBS, MD Professor, Chief of Infectious Disease, Department of Internal Medicine, Wayne State University School of Medicine

Pranatharthi Haran Chandrasekar, MBBS, MD is a member of the following medical societies: American College of Physicians, American Society for Microbiology, International Immunocompromised Host Society, Infectious Diseases Society of America

Disclosure: Nothing to disclose.

Vidya R Devarajan, MD Physician in Infectious Disease, Infectious Disease Consultants of N Kentucky, St Elizabeth Healthcare

Disclosure: Nothing to disclose.

Bryan A T Lim, MD Chief Fellow, Department of Medicine, Section of Infectious Diseases, Philippine General Hospital, University of the Philippines Manila College of Medicine, Philippines

Disclosure: Nothing to disclose.

Wesley W Emmons, MD, FACP Assistant Professor, Department of Medicine, Thomas Jefferson University; Consulting Staff, Infectious Diseases Section, Department of Internal Medicine, Christiana Care, Newark, DE

Wesley W Emmons, MD, FACP is a member of the following medical societies: American College of Physicians, American Medical Association, American Society of Tropical Medicine and Hygiene, Infectious Diseases Society of America, and International AIDS Society

Disclosure: Nothing to disclose.

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