Herpangina Follow-up

Updated: Jun 02, 2022
  • Author: Sandra G Gompf, MD, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
  • Print

Further Outpatient Care

Because symptoms associated with herpangina are usually short-lived and resolve within 1 week, patients generally do not need outpatient follow-up care.



Enteroviruses are spread through the fecal-oral route; therefore, emphasis is placed on measures that may help reduce this mode of spread, especially hand hygiene. A Chinese study of risk factors for herpangina found increased risk posed by playing with neighborhood children, visiting an outpatient clinic within the week before onset of illness, and exposure to crowded public spaces. The same study found significant correlation of good hand hygiene practices with reduced incidence of disease. Low hand hygiene scores were found in 50% of cases versus 2.5% of controls; on the other hand, high hand hygiene scores were found in 12% of cases versus 78% of controls. [21]

The development of a vaccine to eradicate enterovirus 71 has been a priority. Recently, preliminary results of several in vitro and animal studies are encouraging. In particular, VP1 capsid protein of enterovirus 71, identified as a potent inducer of neutralizing antibody titer, shows promise in the development of a potential vaccine. [22]



Herpangina is a self-limited viral illness. Most cases resolve without complications. However, more severe enteroviral manifestations such as aseptic meningitis and neurological manifestations occur in very rare cases. Note a possible association of herpangina during pregnancy with low birth weight, small-for-gestational-age infants, or preterm delivery. See Mortality/Morbidity.



Except for rare cases in which herpangina is accompanied by more severe manifestations of enterovirus infection, herpangina carries an excellent prognosis.