Intestinal Flukes Medication

Updated: Jul 14, 2016
  • Author: Joseph Adrian L Buensalido, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Medication

Medication Summary

The goals of pharmacotherapy are to reduce morbidity, to prevent complications, and to eradicate the infection.

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Anthelmintics

Class Summary

The biochemical pathways in parasites are different enough from those of the human host to allow selective interference with chemotherapeutic agents in relatively small doses.

Praziquantel (Biltricide)

DOC in most infections and active against all schistosomal species. Increases cell membrane permeability in susceptible worms, resulting in loss of intracellular calcium, massive contractions, and paralysis of their musculature. In addition, produces vacuolization and disintegration of schistosome tegument. This is followed by attachment of phagocytes to the parasites and death. Patients should swallow tabs whole with liquid during meals. Keeping tabs in the mouth may result in a bitter taste, which can produce nausea or vomiting.

Albendazole (Albenza)

Decreases ATP production in worms, causing energy depletion, immobilization, and finally, death.

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