Klebsiella Infections Questions & Answers

1. Oliveira J, Reygaert WC. Gram Negative Bacteria. 2022 Jan. [QxMD MEDLINE Link]. [Full Text].

2. Mandell. Enterobacteriaceae. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 7th ed. Churchill Livingstone, An Imprint of Elsevier; 2009.

3. Nordmann P, Cuzon G, Naas T. The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect Dis. 2009 Apr. 9(4):228-36. [QxMD MEDLINE Link].

4. Zhou Y, Wang X, Shen J, Lu Z, Liu Y. Endogenous Endophthalmitis Caused by Carbapenem-Resistant Hypervirulent Klebsiella Pneumoniae: A Case Report and Literature Review. Ocul Immunol Inflamm. 2018 Sep 19. 1-6. [QxMD MEDLINE Link].

5. Liu Z, Gu Y, Li X, Liu Y, Ye Y, Guan S, et al. Identification and Characterization of NDM-1-producing Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae in China. Ann Lab Med. 2019 Mar. 39 (2):167-175. [QxMD MEDLINE Link].

6. Suzuki K, Yamaguchi T, Yanai M. Simultaneous occurrence of hypermucoviscous Klebsiella pneumoniae emphysematous prostatic abscess, emphysematous cystitis, and renal abscess. IDCases. 2018. 14:e00464. [QxMD MEDLINE Link].

7. Liu C, Guo J. Hypervirulent Klebsiella pneumoniae (hypermucoviscous and aerobactin positive) infection over 6 years in the elderly in China: antimicrobial resistance patterns, molecular epidemiology and risk factor. Ann Clin Microbiol Antimicrob. 2019 Jan 21. 18 (1):4. [QxMD MEDLINE Link].

8. Won SY, Munoz-Price LS, Lolans K, Hota B, Weinstein RA, Hayden MK. Emergence and Rapid Regional Spread of Klebsiella pneumoniae Carbapenemase-Producing Enterobacteriaceae. Clin Infect Dis. 2011 Sep. 53(6):532-540. [QxMD MEDLINE Link].

9. Livermore DM. Fourteen years in resistance. Int J Antimicrob Agents. 2012 Apr. 39(4):283-94. [QxMD MEDLINE Link].

10. Miftode E, Dorneanu O, Leca D, Teodor A, Mihalache D, Filip O, et al. [Antimicrobial resistance profile of E. coli and Klebsiella spp. from urine in the Infectious Diseases Hospital Iasi]. Rev Med Chir Soc Med Nat Iasi. 2008 Apr-Jun. 113(2):478-82. [QxMD MEDLINE Link].

11. Tu YC, Lu MC, Chiang MK, Huang SP, Peng HL, Chang HY, et al. Genetic requirements for Klebsiella pneumoniae-induced liver abscess in an oral infection model. Infect Immun. 2009 May 11. [QxMD MEDLINE Link].

12. Munoz-Price LS, Poirel L, Bonomo RA, Schwaber MJ, Daikos GL, Cormican M, et al. Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Lancet Infect Dis. 2013 Sep. 13(9):785-96. [QxMD MEDLINE Link].

13. Fevre C, Passet V, Deletoile A, Barbe V, Frangeul L, Almeida AS, et al. PCR-based identification of Klebsiella pneumoniae subsp. rhinoscleromatis, the agent of rhinoscleroma. PLoS Negl Trop Dis. 2011 May. 5(5):e1052. [QxMD MEDLINE Link]. [Full Text].

14. Gupta N, Limbago BM, Patel JB, Kallen AJ. Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention. Clin Infect Dis. 2011 Jul 1. 53(1):60-7. [QxMD MEDLINE Link].

15. van Duin D, Bonomo RA. Ceftazidime/Avibactam and Ceftolozane/Tazobactam: Second-generation β-Lactam/β-Lactamase Inhibitor Combinations. Clin Infect Dis. 2016 Jul 15. 63 (2):234-41. [QxMD MEDLINE Link]. [Full Text].

16. Loutit JS, et al. Meropenem-Vaborbactam (MV) Compared With Piperacillin-Tazobactam (PT) in the Treatment of Adults With Complicated Urinary Tract Infections (cUTI), Including Acute Pyelonephritis (AP) in a Phase 3 Randomized, Double-Blind, Double-Dummy Trial (TANGO 1). Open Forum Infectious Diseases. 2016. Vol. 3. No. suppl_1:Presented at the Infectious Diseases Society of America IDWeek. San Diego, CA. October 4-8, 2017. [Full Text].

17. Pranita D Tamma. IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram Negative Infections: Version 1.0. March 7 2022. [Full Text].

18. Doyle D, Peirano G, Lascols C, Lloyd T, Church DL, Pitout JD. Laboratory detection of Enterobacteriaceae that produce carbapenemases. J Clin Microbiol. 2012 Dec. 50(12):3877-80. [QxMD MEDLINE Link]. [Full Text].

19. Weisenberg SA, Morgan DJ, Espinal-Witter R, Larone DH. Clinical outcomes of patients with Klebsiella pneumoniae carbapenemase-producing K. pneumoniae after treatment with imipenem or meropenem. Diagn Microbiol Infect Dis. 2009 Apr 1. [QxMD MEDLINE Link].

20. Chan YR, Liu JS, Pociask DA, Zheng M, Mietzner TA, Berger T, et al. Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. J Immunol. 2009 Apr 15. 182(8):4947-56. [QxMD MEDLINE Link].

21. Adams-Haduch JM, Potoski BA, Sidjabat HE, Paterson DL, Doi Y. Activity of Temocillin against KPC-Producing Klebsiella pneumoniae and Escherichia coli. Antimicrob Agents Chemother. 2009 Mar 30. [QxMD MEDLINE Link].

22. Al-Rabea AA, Burwen DR, Eldeen MA, et al. Klebsiella pneumoniae bloodstream infections in neonates in a hospital in the Kingdom of Saudi Arabia. Infect Control Hosp Epidemiol. 1998 Sep. 19(9):674-9. [QxMD MEDLINE Link].

23. Anderson MJ, Janoff EN. Klebsiella endocarditis: report of two cases and review. Clin Infect Dis. 1998 Feb. 26(2):468-74. [QxMD MEDLINE Link].

24. Blaser J, Konig C, Simmen HP, Thurnheer U. Monitoring serum concentrations for once-daily netilmicin dosing regimens. J Antimicrob Chemother. 1994 Feb. 33(2):341-8. [QxMD MEDLINE Link].

25. Bodey GP, Elting LS, Rodriquez S, Hernandez M. Klebsiella bacteremia. A 10-year review in a cancer institution. Cancer. 1989 Dec 1. 64(11):2368-76. [QxMD MEDLINE Link].

26. Branger J, Florquin S, Knapp S. LPS-binding protein-deficient mice have an impaired defense against Gram-negative but not Gram-positive pneumonia. Int Immunol. 2004 Nov. 16(11):1605-11. [QxMD MEDLINE Link].

27. Einstein BI. Enterobacteriaceae. In: Mandell GL, Bennett JE, Dolin E, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Vol 2. 5th ed. New York, NY: Churchill Livingstone; 2000:. 2294-310.

28. Farmer JJ. Enterobacteriaceae: Introduction and identification. In: Murray PR, Baron, EJ, Pfaller MA, eds. Manual of Clinical Microbiology. 7th ed. Washington, DC: American Society for Microbiology; 1999:. 438-47.

29. Fisman DN, Kaye KM. Once-daily dosing of aminoglycoside antibiotics. Infect Dis Clin North Am. 2000 Jun. 14(2):475-87. [QxMD MEDLINE Link].

30. Gamea AM, el-Tatawi FA. The effect of rifampicin on rhinoscleroma: an electron microscopic study. J Laryngol Otol. 1990 Oct. 104(10):772-7. [QxMD MEDLINE Link].

31. Hirche TO, Gaut JP, Heinecke JW. Myeloperoxidase plays critical roles in killing Klebsiella pneumoniae and inactivating neutrophil elastase: effects on host defense. J Immunol. 2005 Feb 1. 174(3):1557-65. [QxMD MEDLINE Link].

32. Kaye KS, Fraimow HS, Abrutyn E. Pathogens resistant to antimicrobial agents. Epidemiology, molecular mechanisms, and clinical management. Infect Dis Clin North Am. 2000 Jun. 14(2):293-319. [QxMD MEDLINE Link].

33. Khimji PL, Miles AA. Microbial iron-chelators and their action on Klebsiella infections in the skin of guinea-pigs. Br J Exp Pathol. 1978 Apr. 59(2):137-47. [QxMD MEDLINE Link].

34. Kobashi Y, Fujita K, Karino T, et al. [Clinical analysis of community-acquired pneumonia requiring hospitalization in a community hospital--comparison of elderly and non-elderly patients]. Kansenshogaku Zasshi. 2000 Jan. 74(1):43-50. [QxMD MEDLINE Link].

35. Kobashi Y, Ohba H, Yoneyama H, et al. [Clinical analysis of patients with community-acquired pneumonia requiring hospitalization classified by age group]. Kansenshogaku Zasshi. 2001 Mar. 75(3):193-200. [QxMD MEDLINE Link].

36. Korvick JA, Bryan CS, Farber B, et al. Prospective observational study of Klebsiella bacteremia in 230 patients: outcome for antibiotic combinations versus monotherapy. Antimicrob Agents Chemother. 1992 Dec. 36(12):2639-44. [QxMD MEDLINE Link].

37. Liam CK, Lim KH, Wong CM. Community-acquired pneumonia in patients requiring hospitalization. Respirology. 2001 Sep. 6(3):259-64. [QxMD MEDLINE Link].

38. Lucente FE. Rhinitis and nasal obstruction. Otolaryngol Clin North Am. 1989 Apr. 22(2):307-18. [QxMD MEDLINE Link].

39. Mentec H, Vallois JM, Bure A, et al. Piperacillin, tazobactam, and gentamicin alone or combined in an endocarditis model of infection by a TEM-3-producing strain of Klebsiella pneumoniae or its susceptible variant. Antimicrob Agents Chemother. 1992 Sep. 36(9):1883-9. [QxMD MEDLINE Link].

40. Merino S, Camprubi S, Alberti S, et al. Mechanisms of Klebsiella pneumoniae resistance to complement-mediated killing. Infect Immun. 1992 Jun. 60(6):2529-35. [QxMD MEDLINE Link].

41. Nicolau DP, Freeman CD, Belliveau PP, et al. Experience with a once-daily aminoglycoside program administered to 2,184 adult patients. Antimicrob Agents Chemother. 1995 Mar. 39(3):650-5. [QxMD MEDLINE Link].

42. Paterson DL. Recommendation for treatment of severe infections caused by Enterobacteriaceae producing extended-spectrum beta-lactamases (ESBLs). Clin Microbiol Infect. 2000 Sep. 6(9):460-3. [QxMD MEDLINE Link].

43. Paterson DL, Trenholme GM. Klebsiella species. In: Yu VL, Merigan TC, Barriere SL, eds. Antimicrobial therapy and vaccines. Baltimore, Md: Williams & Wilkins; 1999:. 239-48.

44. Podschun R, Ullmann U. Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol Rev. 1998 Oct. 11(4):589-603. [QxMD MEDLINE Link].

45. Prabaker K, Lin MY, McNally M, Cherabuddi K, Ahmed S, Norris A. Transfer from high-acuity long-term care facilities is associated with carriage of Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae: a multihospital study. Infect Control Hosp Epidemiol. 2012 Dec. 33(12):1193-9. [QxMD MEDLINE Link].

46. Prince SE, Dominger KA, Cunha BA, Klein NC. Klebsiella pneumoniae pneumonia. Heart Lung. 1997 Sep-Oct. 26(5):413-7. [QxMD MEDLINE Link].

47. Restuccia PA, Cunha BA. Klebsiella. Infect Control. 1984 Jul. 5(7):343-7. [QxMD MEDLINE Link].

48. Rice L. Evolution and clinical importance of extended-spectrum beta-lactamases. Chest. 2001 Feb. 119(2 Suppl):391S-396S. [QxMD MEDLINE Link].

49. Riser E, Noone P, Howard FM. Epidemiological study of klebsiella infection in the special care baby unit of a London hospital. J Clin Pathol. 1980 Apr. 33(4):400-7. [QxMD MEDLINE Link].

50. Sahly H, Podschun R. Clinical, bacteriological, and serological aspects of Klebsiella infections and their spondyloarthropathic sequelae. Clin Diagn Lab Immunol. 1997 Jul. 4(4):393-9. [QxMD MEDLINE Link].

51. Sahly H, Podschun R, Ullmann U. Klebsiella infections in the immunocompromised host. Adv Exp Med Biol. 2000. 479:237-49. [QxMD MEDLINE Link].

52. Sedor J, Mulholland SG. Hospital-acquired urinary tract infections associated with the indwelling catheter. Urol Clin North Am. 1999 Nov. 26(4):821-8. [QxMD MEDLINE Link].

53. Segal-Maurer S, Mariano N, Qavi A, et al. Successful treatment of ceftazidime-resistant Klebsiella pneumoniae ventriculitis with intravenous meropenem and intraventricular polymyxin B: case report and review. Clin Infect Dis. 1999 May. 28(5):1134-8. [QxMD MEDLINE Link].

54. Sidjabat H, Nimmo GR, Walsh TR, Binotto E, Htin A, Hayashi Y, et al. Carbapenem resistance in Klebsiella pneumoniae due to the New Delhi Metallo-ß-lactamase. Clin Infect Dis. 2011 Feb. 52(4):481-4. [QxMD MEDLINE Link].

55. Toivanen P, Hansen DS, Mestre F. Somatic serogroups, capsular types, and species of fecal Klebsiella in patients with ankylosing spondylitis. J Clin Microbiol. 1999 Sep. 37(9):2808-12. [QxMD MEDLINE Link].

56. Tomas JM, Benedi VJ, Ciurana B, Jofre J. Role of capsule and O antigen in resistance of Klebsiella pneumoniae to serum bactericidal activity. Infect Immun. 1986 Oct. 54(1):85-9. [QxMD MEDLINE Link].

57. Urban AW, Craig WA. Daily dosage of aminoglycosides. Curr Clin Top Infect Dis. 1997. 17:236-55. [QxMD MEDLINE Link].

58. Warren JW. Catheter-associated urinary tract infections. Int J Antimicrob Agents. 2001 Apr. 17(4):299-303. [QxMD MEDLINE Link].

59. Zohar Y, Talmi YP, Strauss M, et al. Ozena revisited. J Otolaryngol. 1990 Oct. 19(5):345-9. [QxMD MEDLINE Link].

60. Moore PP, McGowan GF, Sandhu SS, Allen PJ. Klebsiella pneumoniae liver abscess complicated by endogenous endophthalmitis: the importance of early diagnosis and intervention. Med J Aust. 2015 Oct 5. 203 (7):300-1. [QxMD MEDLINE Link].

Shahab Qureshi, MD, FACP Attending Physician in General Internal Medicine, St Catharine's General Hospital; Associate Clinical Professor (Adjunct), McMaster University School of Medicine, Canada

Shahab Qureshi, MD, FACP is a member of the following medical societies: American College of Physicians, College of Physicians and Surgeons of Ontario, Ontario Medical Association

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

John W King, MD Professor of Medicine, Chief, Section of Infectious Diseases, Director, Viral Therapeutics Clinics for Hepatitis, Louisiana State University School of Medicine in Shreveport; Consultant in Infectious Diseases, Overton Brooks Veterans Affairs Medical Center

John W King, MD is a member of the following medical societies: American Association for the Advancement of Science, American College of Physicians, American Federation for Medical Research, American Society for Microbiology, Association of Subspecialty Professors, Infectious Diseases Society of America, Sigma Xi, The Scientific Research Honor Society

Disclosure: Nothing to disclose.

Michael Stuart Bronze, MD David Ross Boyd Professor and Chairman, Department of Medicine, Stewart G Wolf Endowed Chair in Internal Medicine, Department of Medicine, University of Oklahoma Health Science Center; Master of the American College of Physicians; Fellow, Infectious Diseases Society of America; Fellow of the Royal College of Physicians, London

Michael Stuart Bronze, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians, American Medical Association, Association of Professors of Medicine, Infectious Diseases Society of America, Oklahoma State Medical Association, Southern Society for Clinical Investigation

Disclosure: Nothing to disclose.

David Hall Shepp, MD Program Director, Fellowship in Infectious Diseases, Department of Medicine, North Shore University Hospital; Associate Professor, New York University School of Medicine

David Hall Shepp, MD is a member of the following medical societies: Infectious Diseases Society of America

Disclosure: Received salary from Gilead Sciences for management position.

Leonard B Berkowitz, MD Chief, Divisions of Infectious Diseases and HIV/AIDS Services, Brooklyn Hospital Center; Clinical Assistant Professor, Department of Medicine, State University of New York at Brooklyn

Leonard B Berkowitz, MD is a member of the following medical societies: American College of Physicians, American Society for Microbiology, Infectious Diseases Society of America, and Phi Beta Kappa

Disclosure: Nothing to disclose.

Obiamiwe Umeh, MBBS Fellow, Center for AIDS Research and Education, David Geffen School of Medicine at UCLA

Obiamiwe Umeh, MBBS is a member of the following medical societies: American College of Physicians and American Medical Association

Disclosure: Nothing to disclose.

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