Lymphogranuloma Venereum (LGV) Guidelines

Updated: Jun 22, 2021
  • Author: John L Kiley, MD; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Guidelines Summary

Multiple guidelines exist that reference the treatment of LGV. The CDC 2015 STI Guidelines are soon to be updated - but will not contain any changes to the recommendation that LGV be treated first line with doxycycline. [35]  The 2019 European guideline on the management of lymphogranuloma venereum is an excellent summary of the clinical data available to date. [39]


WHO Guidelines on the Treatment of Lymphogranuloma Venereum

WHO recommendations for the treatment of lymphogranuloma venereum (LGV) are as follows [40] :

  • In adults and adolescents with LGV, the guidelines suggest doxycycline 100 mg orally twice daily for 21 days over azithromycin 1 g orally weekly for 3 weeks.
  • When doxycycline is contraindicated, azithromycin should be provided.
  • When neither treatment is available, erythromycin 500 mg orally 4 times a day for 21 days is an alternative.
  • Doxycycline should not be used in pregnant women.