Castleman Disease Questions & Answers

1. van Rhee F, Munshi NC. Castleman Disease. Hematol Oncol Clin North Am. 2018 Feb. 32 (1):xiii-xiv. [QxMD MEDLINE Link].

2. Castleman B, Iverson L, Menendez VP. Localized mediastinal lymphnode hyperplasia resembling thymoma. Cancer. 1956 Jul-Aug. 9(4):822-30. [QxMD MEDLINE Link].

3. Haap M, Wiefels J, Horger M, Hoyer A, Müssig K. Clinical, laboratory and imaging findings in Castleman's disease - The subtype decides. Blood Rev. May 2018. 32(3):225-234. [QxMD MEDLINE Link]. [Full Text].

4. Yu L, Tu M, Cortes J, Xu-Monette ZY, Miranda RN, Zhang J, et al. Clinical and pathological characteristics of HIV- and HHV-8-negative Castleman disease. Blood. 2017 Mar 23. 129 (12):1658-1668. [QxMD MEDLINE Link].

5. Yoshizaki K, Matsuda T, Nishimoto N, Kuritani T, Taeho L, Aozasa K, et al. Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease. Blood. 1989 Sep. 74(4):1360-7. [QxMD MEDLINE Link].

6. Leger-Ravet MB, Peuchmaur M, Devergne O, Audouin J, Raphael M, Van Damme J, et al. Interleukin-6 gene expression in Castleman's disease. Blood. 1991 Dec 1. 78(11):2923-30. [QxMD MEDLINE Link].

7. Stone K, Woods E, Szmania SM, Stephens OW, Garg TK, Barlogie B, et al. Interleukin-6 receptor polymorphism is prevalent in HIV-negative Castleman Disease and is associated with increased soluble interleukin-6 receptor levels. PLoS One. 2013. 8(1):e54610. [QxMD MEDLINE Link]. [Full Text].

8. Talat N, Belgaumkar AP, Schulte KM. Surgery in Castleman's disease: a systematic review of 404 published cases. Ann Surg. 2012 Apr. 255(4):677-84. [QxMD MEDLINE Link].

9. Dupin N, Diss TL, Kellam P, Tulliez M, Du MQ, Sicard D, et al. HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8-positive plasmablastic lymphoma. Blood. 2000 Feb 15. 95(4):1406-12. [QxMD MEDLINE Link].

10. [Guideline] Fajgenbaum DC, Uldrick TS, Bagg A, Frank D, Wu D, et al. International, evidence-based consensus diagnostic criteria for HHV-8-negative/idiopathic multicentric Castleman disease. Blood. 2017 Mar 23. 129 (12):1646-1657. [QxMD MEDLINE Link]. [Full Text].

11. Casper C. The aetiology and management of Castleman disease at 50 years: translating pathophysiology to patient care. Br J Haematol. 2005 Apr. 129(1):3-17. [QxMD MEDLINE Link].

12. Chan KL, Lade S, Prince HM, Harrison SJ. Update and new approaches in the treatment of Castleman disease. J Blood Med. 2016. 7:145-58. [QxMD MEDLINE Link]. [Full Text].

13. Haap M, Wiefels J, Horger M, Hoyer A, Müssig K. Clinical, laboratory and imaging findings in Castleman's disease - The subtype decides. Blood Rev. 2018 May. 32(3):225-234. [QxMD MEDLINE Link]. [Full Text].

14. [Guideline] NCCN Clinical Practice Guidelines in Oncology. B-Cell Lymphomas. National Comprehensive Cancer Network. Available at https://www.nccn.org/professionals/physician_gls/pdf/b-cell.pdf. Version 5.2022 — July 12, 2022; Accessed: January 9, 2023.

15. [Guideline] van Rhee F, Voorhees P, Dispenzieri A, et al. International, evidence-based consensus treatment guidelines for idiopathic multicentric Castleman disease. Blood. 2018 Nov 15. 132(20):2115-2124. [QxMD MEDLINE Link]. [Full Text].

16. Barker R, Kazmi F, Stebbing J, Ngan S, Chinn R, Nelson M, et al. FDG-PET/CT imaging in the management of HIV-associated multicentric Castleman's disease. Eur J Nucl Med Mol Imaging. 2009 Apr. 36(4):648-52. [QxMD MEDLINE Link].

17. Bower M. How I treat HIV-associated multicentric Castleman disease. Blood. 2010 Nov 25. 116(22):4415-21. [QxMD MEDLINE Link].

18. Bower M, Powles T, Williams S, Davis TN, Atkins M, Montoto S, et al. Brief communication: rituximab in HIV-associated multicentric Castleman disease. Ann Intern Med. 2007 Dec 18. 147(12):836-9. [QxMD MEDLINE Link].

19. Wong RS, Casper C, Munshi N, et al. A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Of The Efficacy and Safety Of Siltuximab, An Anti-Interleukin-6 Monoclonal Antibody, In Patients With Multicentric Castleman’s Disease. Blood. Nov 15 2013. 122(21):505. [Full Text].

20. Sobas MA, Alonso Vence N, Diaz Arias J, Bendaña Lopez A, Fraga Rodriguez M, Bello Lopez JL. Efficacy of bortezomib in refractory form of multicentric Castleman disease associated to poems syndrome (MCD-POEMS variant). Ann Hematol. 2010 Feb. 89(2):217-9. [QxMD MEDLINE Link].

21. Wang X, Ye S, Xiong C, Gao J, Xiao C, Xing X. Successful treatment with bortezomib and thalidomide for POEMS syndrome associated with multicentric mixed-type Castleman's disease. Jpn J Clin Oncol. 2011 Oct. 41(10):1221-4. [QxMD MEDLINE Link].

22. Scott D, Cabral L, Harrington WJ Jr. Treatment of HIV-associated multicentric Castleman's disease with oral etoposide. Am J Hematol. 2001 Feb. 66(2):148-50. [QxMD MEDLINE Link].

23. Chronowski GM, Ha CS, Wilder RB, Cabanillas F, Manning J, Cox JD. Treatment of unicentric and multicentric Castleman disease and the role of radiotherapy. Cancer. 2001 Aug 1. 92(3):670-6. [QxMD MEDLINE Link].

24. Talat N, Schulte KM. Castleman's disease: systematic analysis of 416 patients from the literature. Oncologist. 2011. 16(9):1316-24. [QxMD MEDLINE Link]. [Full Text].

25. Beck JT, Hsu SM, Wijdenes J, Bataille R, Klein B, Vesole D, et al. Brief report: alleviation of systemic manifestations of Castleman's disease by monoclonal anti-interleukin-6 antibody. N Engl J Med. 1994 Mar 3. 330(9):602-5. [QxMD MEDLINE Link].

26. Kawabata H, Tomosugi N, Kanda J, Tanaka Y, Yoshizaki K, Uchiyama T. Anti-interleukin 6 receptor antibody tocilizumab reduces the level of serum hepcidin in patients with multicentric Castleman's disease. Haematologica. 2007 Jun. 92(6):857-8. [QxMD MEDLINE Link].

27. van Rhee F, Fayad L, Voorhees P, Furman R, Lonial S, Borghaei H, et al. Siltuximab, a novel anti-interleukin-6 monoclonal antibody, for Castleman's disease. J Clin Oncol. 2010 Aug 10. 28(23):3701-8. [QxMD MEDLINE Link].

28. van Rhee F, Wong RS, Munshi N, Rossi JF, Ke XY, Fosså A, et al. Siltuximab for multicentric Castleman's disease: a randomised, double-blind, placebo-controlled trial. Lancet Oncol. 2014 Aug. 15(9):966-74. [QxMD MEDLINE Link].

29. Patel M, Ikeda S, Pilat SR, Kurzrock R. JAK1 Genomic Alteration Associated With Exceptional Response to Siltuximab in Cutaneous Castleman Disease. JAMA Dermatol. 2017 May 1. 153 (5):449-452. [QxMD MEDLINE Link].

30. Uldrick TS, Polizzotto MN, Aleman K, O'Mahony D, Wyvill KM, Wang V, et al. High-dose zidovudine plus valganciclovir for Kaposi sarcoma herpesvirus-associated multicentric Castleman disease: a pilot study of virus-activated cytotoxic therapy. Blood. 2011 Jun 30. 117(26):6977-86. [QxMD MEDLINE Link]. [Full Text].

31. Marcelin AG, Aaron L, Mateus C, Gyan E, Gorin I, Viard JP, et al. Rituximab therapy for HIV-associated Castleman disease. Blood. 2003 Oct 15. 102(8):2786-8. [QxMD MEDLINE Link].

Geneva E Guarin, MD, MBA Resident Physician, Department of Internal Medicine, Einstein Medical Center Philadelphia

Disclosure: Nothing to disclose.

Claudia M da Costa Dourado, MD Clinical Assistant Professor of Medicine, Sidney Kimmel Medical College of Thomas Jefferson University; Program Director, Hematology and Medical Oncology Fellowship Program, Attending Physician, Division of Hematology and Medical Oncology, Department of Medicine, Einstein Medical Center Philadelphia

Claudia M da Costa Dourado, MD is a member of the following medical societies: American Society of Clinical Oncology, American Society of Hematology

Disclosure: Nothing to disclose.

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

David C Fajgenbaum, MD, MSc, MBA Research Assistant Professor of Medicine, Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania; Associate Director, Patient Impact, Orphan Disease Center, Division of Medical Genetics, Hospital of the University of Pennsylvania

David C Fajgenbaum, MD, MSc, MBA is a member of the following medical societies: American Society of Hematology

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: EUSA Pharma<br/>Received research grant from: EUSA Pharma.

Emmanuel C Besa, MD Professor Emeritus, Department of Medicine, Division of Hematologic Malignancies and Hematopoietic Stem Cell Transplantation, Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University

Emmanuel C Besa, MD is a member of the following medical societies: American Association for Cancer Education, American Society of Clinical Oncology, American College of Clinical Pharmacology, American Federation for Medical Research, American Society of Hematology, New York Academy of Sciences

Disclosure: Nothing to disclose.

Neetu Radhakrishnan, MD Medical Oncologist, Kettering Cancer Care

Neetu Radhakrishnan, MD is a member of the following medical societies: American College of Physicians, American Society of Clinical Oncology, American Society of Hematology

Disclosure: Nothing to disclose.

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