Mycobacterium Haemophilum Treatment & Management

Updated: Oct 07, 2015
  • Author: Natalie C Klein, MD, PhD; Chief Editor: Mark R Wallace, MD, FACP, FIDSA  more...
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Medical Care

Treatment is determined by the degree of immunosuppression. In healthy children with lymphadenitis, surgical excision is the preferred treatment. In immunosuppressed patients, reversal of immunosuppression is the most effective treatment. Immunosuppressed patients require combination therapy to prevent the development of resistance. Susceptibility testing is not standardized, but M haemophilum is usually susceptible to amikacin, ciprofloxacin, and other quinolones (eg, levofloxacin, moxifloxacin), clarithromycin, rifabutin, rifampin. M haemophilum is usually resistant to ethambutol, ethionamide, isoniazid, and streptomycin. Although the optimal regimen is not known, combinations have had some clinical success.

Effective drug combinations include the following:

  • Rifampin and ciprofloxacin
  • Ciprofloxacin, clarithromycin, and rifampin
  • Rifampin and minocycline
  • Clarithromycin, minocycline, and rifampin

Surgical Care

Lymphadenitis in children: Total excision of the involved lymph node or nodes is the treatment of choice. [41]



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