Endogenous Cushing Syndrome Questions & Answers

Updated: Oct 18, 2018
  • Author: Ha Cam Thuy Nguyen, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Questions & Answers

Overview

What is the clinical background of endogenous Cushing syndrome?

What is the pathophysiology of endogenous Cushing syndrome?

What are the causes of endogenous glucocorticoid overproduction in ACTH-independent Cushing syndrome?

What are the causes of endogenous glucocorticoid overproduction in ACTH-dependent Cushing syndrome?

How common is endogenous Cushing syndrome?

What is the prognosis of endogenous Cushing syndrome?

What are potential complications of endogenous Cushing syndrome?

What are the prognostic findings in ectopic Cushing syndrome?

What education should be provided to patients with endogenous Cushing syndrome?

Presentation

What is the clinical history of endogenous Cushing syndrome?

What are the signs and symptoms of endogenous Cushing syndrome?

How is obesity characterized in endogenous Cushing syndrome?

What are the skin manifestations of endogenous Cushing syndrome?

What are the cardiovascular and renal findings in endogenous Cushing syndrome?

What are the GI findings in endogenous Cushing syndrome?

What are the endocrine findings in endogenous Cushing syndrome?

What are the musculoskeletal findings in endogenous Cushing syndrome?

What are the neuropsychological findings in patients with endogenous Cushing syndrome?

Which findings suggest adrenal crisis in endogenous Cushing syndrome?

DDX

How are endogenous Cushing syndrome and pseudo-Cushing syndrome distinguished?

What are the differential diagnoses for Endogenous Cushing Syndrome?

Workup

What are the approach considerations in the workup of endogenous Cushing syndrome?

Which lab studies can provide a definitive diagnosis of endogenous Cushing syndrome?

What are the screening tests for endogenous Cushing syndrome?

What is the role of urinary free cortisol (UFC) measurement in the diagnosis of endogenous Cushing syndrome?

What is the role of the dexamethasone suppression test in the workup of endogenous Cushing syndrome?

How accurate is late-night salivary cortisol testing in the diagnosis of Cushing syndrome?

What are the possible confounders in the lab results in endogenous Cushing syndrome?

What is the next step once a diagnosis of endogenous Cushing syndrome is established?

Which lab studies are used to determine the etiology of endogenous Cushing syndrome?

Which imaging studies are indicated in the workup of endogenous Cushing syndrome?

Which clinical procedures are indicated in the workup of endogenous Cushing syndrome?

Treatment

What is the treatment approach in endogenous Cushing syndrome?

What are the Endocrine Society treatment guidelines for endogenous Cushing syndrome?

Which medications are used in the treatment of endogenous Cushing syndrome?

What is the role of pasireotide in the treatment of endogenous Cushing syndrome?

Which steroidogenesis inhibitors are indicated in the treatment of endogenous Cushing syndrome?

What are the adverse effects of ketoconazole in the treatment of endogenous Cushing syndrome?

What is the role of etomidate in the treatment of endogenous Cushing syndrome?

What is the role of mifepristone in the treatment of endogenous Cushing syndrome?

What are the treatment options for persistent or recurrent Cushing disease?

What is the treatment of choice for endogenous Cushing syndrome?

What are the surgical options for the treatment of endogenous Cushing syndrome?

What treatment is indicated in patients with endogenous Cushing syndrome who undergo tumor resection?

What is the treatment of choice for classic Cushing disease?

What are the treatment options for ectopic ACTH-producing tumors in endogenous Cushing syndrome?

What surgical treatment is indicated on the adrenal gland in endogenous Cushing syndrome?

Which specialist consultations are indicated in the treatment of endogenous Cushing syndrome?

What are the potential complications of treatment for endogenous Cushing syndrome?

Medications

What is the goal of drug treatment of endogenous Cushing syndrome?

Which medications in the drug class Cortisol Receptor Blockers are used in the treatment of Endogenous Cushing Syndrome?

Which medications in the drug class Antineoplastic agents, other are used in the treatment of Endogenous Cushing Syndrome?

Which medications in the drug class Adrenal steroid inhibitors are used in the treatment of Endogenous Cushing Syndrome?

Which medications in the drug class Somatostatin Analogs are used in the treatment of Endogenous Cushing Syndrome?