Bacterial Pharyngitis Clinical Presentation

Updated: Mar 17, 2016
  • Author: Maria A Carrillo-Marquez, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Presentation

History

The signs and symptoms listed below may be seen with many non-GABHS etiologies. Furthermore, individuals with GABHS pharyngitis may have only a few or mild features listed. Conjunctivitis, cough, hoarseness, coryza, diarrhea, anterior stomatitis, discrete ulcerative lesions, and a viral exanthem are all more consistent with an etiology other than GABHS, particularly viral.

  • Sore throat, usually with sudden onset
  • Odynophagia
  • Headache
  • Nausea, vomiting, and abdominal pain
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Physical

Physical examination may reveal the following:

  • Fever
  • Tonsillopharyngeal erythema
  • Exudates (patchy and discrete)
  • Beefy red swollen uvula
  • Lymphadenopathy (tender anterior cervical nodes)
  • Petechiae on the palate
  • Scarlatiniform rash (In susceptible hosts, this usually manifests within the first two days of symptoms and causes a finely papular, blanching, and erythematous rash. The neck is often first affected and then spreads along the trunk and limbs. Resolution, often at 3-4 days, occurs in roughly the same order of appearance and often results in desquamation of the involved areas.)

Predictive models have been developed to help determine the likelihood of GABHS pharyngitis based on the presence of fever, swollen tender anterior cervical lymph nodes, and tonsillar exudates and the absence of cough. Scores have been used to distinguish which patients merit further laboratory evaluation or treatment. The use of such clinical algorithms has been the source of much debate. [1, 15] These score systems were originally developed prior to the availability of RADTs and might be helpful in determining which patients to test for GAS pharyngitis but lack sufficient specificity to decide which patients need antibiotic therapy and might result in unnecessary use of antibiotics. [1]

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Causes

Viruses cause the vast majority of pharyngitis cases. Common agents include coronavirus, rhinovirus, adenovirus, parainfluenza, influenza, Epstein-Barr virus, cytomegalovirus, and HIV.

GABHS accounts for 15%-30% of pharyngitis cases in children and 5%-10% of cases in adults. [1] Bacteria other than GABHS that may cause pharyngitis are discussed below.

Group C and G streptococci

Like GABHS, these pathogenic bacteria cause beta-hemolysis, form large colonies, and produce an M protein, yet neither is detected with RADTs, as they lack the group A antigen, which is the target of the test.

Pharyngitis caused by either of these non-GABHS streptococci have a clinical presentation similar to that of GABHS pharyngitis and should be considered in patients with worsening symptoms and an initial negative RADT result. They have been reported in epidemics, particularly in semi-closed populations such as military installations or schools [16, 17, 18] and in sporadic pharyngitis in college students. [19]

These bacteria are an uncommon cause of acute pharyngitis in pediatric patients. [20, 21] They have not been associated with the development of acute rheumatic fever. [22] Diagnosis can be achieved with a bacterial throat culture and identification based on Lancefield antigens. [23]

Arcanobacterium haemolyticum

This gram-positive rod is an uncommon cause of pharyngitis and tonsillitis and accounts for 0.5% and 3% of cases. [24] Clinical manifestations are similar to those of GABHS pharyngitis, although about half of patients with A haemolyticum pharyngitis develop a rash, which typically starts on the extensor surfaces; spares the palms, soles, and head; and moves centrally to involve the trunk with a maculopapular or scarlatiniform appearance.

A haemolyticum exhibits variable susceptibility to penicillin and is identified more easily on human or rabbit blood agar than on sheep agar, the media traditionally used to identify GABHS. It is more common in adolescents and young adults. [25] Erythromycin is the treatment drug of choice. [24]

Neisseria gonorrhoeae

Infection with this pathogen is associated with oral-genital contact and is often asymptomatic. [26] N gonorrhoeae may be identified using chocolate or Thayer-Martin agar. [27] Nucleic acid amplification tests from throat rinses appear to be a promising alternative. [28] Because of increasing rates of fluoroquinolone resistance, ceftriaxone is now the only recommended option for treatment of pharyngeal gonorrhea. [29] Treatment aimed at Chlamydia trachomatis is also recommended, since co-infection is common.

Mycoplasma pneumoniae

This atypical bacterium is increasingly being identified as an etiologic agent of pharyngitis. [30] M pneumoniae pharyngitis may be associated with pulmonary findings. [31]

Yersiniaspecies

Both Yersinia enterocolitica and Yersinia pestis may cause disease. Pharyngeal plague has been linked to the consumption of camel meat. [32]

Chlamydia trachomatisand Chlamydophila pneumoniae

Both of these organisms are rare causes of pharyngitis. [30, 28]

Francisella tularensis(oropharyngeal tularemia)

The causative organism is a gram-negative pleomorphic coccobacillus that can be acquired by ingestion of contaminated water or inadequately cooked game meat. It is an uncommon cause of pharyngitis and tonsillitis in the United States and is usually accompanied by lymphadenitis and severe exudative stomatitis. [33]

Corynebacterium diphtheriae

Toxigenic strains of this gram-positive bacillus are common causes of croup. [34] Young patients with C diphtheriae pharyngitis often exhibit inspiratory stridor, sternal retraction, and a barking cough. In severe cases, a membrane formation may impair breathing. The incidence of C diphtheriae pharyngitis in developed countries is low because of high immunization rates.

Fusobacteriumnecrophorum

This is an anaerobic gram-negative bacillus that can be isolated from the oropharynx of healthy individuals but that has been associated with sore throat. [35] It can also cause life-threatening disease, including Lemierre syndrome or postanginal sepsis (internal jugular vein thrombophlebitis, septic pulmonary emboli, and bacteremia. [36] Some studies also suggest a role for this bacterium in recurrent or persistent sore throat. [37, 38] It is more common in adolescents and young adults.

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