Rhinovirus (RV) Infection (Common Cold) Differential Diagnoses

1. Ljubin-Sternak S, Meštrović T. Rhinovirus-A True Respiratory Threat or a Common Inconvenience of Childhood?. Viruses. 2023 Mar 24. 15 (4):[QxMD MEDLINE Link].

2. Smith A, Kardos P, Pfaar O, Randerath W, Estrada Riolobos G, Braido F, et al. The treatment of mild upper respiratory tract infections - a position paper with recommendations for best practice. Drugs Context. 2023. 12:[QxMD MEDLINE Link].

3. Yamaya M, Kikuchi A, Sugawara M, Nishimura H. Anti-inflammatory effects of medications used for viral infection-induced respiratory diseases. Respir Investig. 2023 Mar. 61 (2):270-283. [QxMD MEDLINE Link].

4. Bizot E, Bousquet A, Charpié M, Coquelin F, Lefevre S, Le Lorier J, et al. Rhinovirus: A Narrative Review on Its Genetic Characteristics, Pediatric Clinical Presentations, and Pathogenesis. Front Pediatr. 2021. 9:643219. [QxMD MEDLINE Link].

5. Busse WW, Gern JE, Dick EC. The role of respiratory viruses in asthma. Ciba Found Symp. 1997. 206:208-13; discussion 213-9. [QxMD MEDLINE Link].

6. Friedlander SL, Busse WW. The role of rhinovirus in asthma exacerbations. J Allergy Clin Immunol. 2005 Aug. 116(2):267-73. [QxMD MEDLINE Link].

7. Bella J, Rossmann MG. Review: rhinoviruses and their ICAM receptors. J Struct Biol. 1999 Dec 1. 128(1):69-74. [QxMD MEDLINE Link].

8. Greve JM, Davis G, Meyer AM, Forte CP, Yost SC, Marlor CW, et al. The major human rhinovirus receptor is ICAM-1. Cell. 1989 Mar 10. 56(5):839-47. [QxMD MEDLINE Link].

9. Saraya T, Kurai D, Ishii H, Ito A, Sasaki Y, Niwa S, et al. Epidemiology of virus-induced asthma exacerbations: with special reference to the role of human rhinovirus. Front Microbiol. 2014. 5:226. [QxMD MEDLINE Link].

10. Royston L, Tapparel C. Rhinoviruses and Respiratory Enteroviruses: Not as Simple as ABC. Viruses. 2016 Jan 11. 8 (1):[QxMD MEDLINE Link].

11. Bochkov YA, Watters K, Ashraf S, Griggs TF, Devries MK, Jackson DJ, et al. Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication. Proc Natl Acad Sci U S A. 2015 Apr 28. 112 (17):5485-90. [QxMD MEDLINE Link].

12. Bønnelykke K, Sleiman P, Nielsen K, Kreiner-Møller E, Mercader JM, Belgrave D, et al. A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations. Nat Genet. 2014 Jan. 46 (1):51-5. [QxMD MEDLINE Link].

13. Andrup L, Krogfelt KA, Hansen KS, Madsen AM. Transmission route of rhinovirus - the causative agent for common cold. A systematic review. Am J Infect Control. 2022 Dec 17. 2022:[QxMD MEDLINE Link]. [Full Text].

14. Kreger JE, Hershenson MB. Effects of COVID-19 and Social Distancing on Rhinovirus Infections and Asthma Exacerbations. Viruses. 2022 Oct 25. 14 (11):[QxMD MEDLINE Link].

15. Brown MA. Rhinovirus and COVID-19 in children: a new order out of chaos?. J Pediatr (Rio J). 2022 Nov-Dec. 98 (6):548-550. [QxMD MEDLINE Link].

16. Teo KW, Patel D, Sisodia S, Roland D, Gaillard EA, Tang JW. Rhinovirus persistence during the COVID-19 pandemic-Impact on pediatric acute wheezing presentations. J Med Virol. 2022 Nov. 94 (11):5547-5552. [QxMD MEDLINE Link].

17. Lessler J, Reich NG, Brookmeyer R, Perl TM, Nelson KE, Cummings DA. Incubation periods of acute respiratory viral infections: a systematic review. Lancet Infect Dis. 2009 May. 9(5):291-300. [QxMD MEDLINE Link].

18. Melchjorsen J, Sørensen LN, Paludan SR. Expression and function of chemokines during viral infections: from molecular mechanisms to in vivo function. J Leukoc Biol. 2003 Sep. 74(3):331-43. [QxMD MEDLINE Link].

19. Message SD, Johnston SL. Host defense function of the airway epithelium in health and disease: clinical background. J Leukoc Biol. 2004 Jan. 75(1):5-17. [QxMD MEDLINE Link].

20. Doyle WJ, Casselbrant ML, Li-Korotky HS, Doyle AP, Lo CY, Turner R, et al. The interleukin 6 -174 C/C genotype predicts greater rhinovirus illness. J Infect Dis. 2010 Jan 15. 201(2):199-206. [QxMD MEDLINE Link]. [Full Text].

21. Jennings LC, Anderson TP, Werno AM, Beynon KA, Murdoch DR. Viral etiology of acute respiratory tract infections in children presenting to hospital: role of polymerase chain reaction and demonstration of multiple infections. Pediatr Infect Dis J. 2004 Nov. 23(11):1003-7. [QxMD MEDLINE Link].

22. Martin ET, Fairchok MP, Stednick ZJ, Kuypers J, Englund JA. Epidemiology of multiple respiratory viruses in childcare attendees. J Infect Dis. 2013 Mar. 207(6):982-9. [QxMD MEDLINE Link].

23. Jin Y, Yuan XH, Xie ZP, Gao HC, Song JR, Zhang RF, et al. Prevalence and clinical characterization of a newly identified human rhinovirus C species in children with acute respiratory tract infections. J Clin Microbiol. 2009 Sep. 47(9):2895-900. [QxMD MEDLINE Link]. [Full Text].

24. Peltola V, Jartti T, Putto-Laurila A, Mertsola J, Vainionpää R, Waris M, et al. Rhinovirus infections in children: a retrospective and prospective hospital-based study. J Med Virol. 2009 Oct. 81(10):1831-8. [QxMD MEDLINE Link].

25. Yoshida LM, Suzuki M, Yamamoto T, Nguyen HA, Nguyen CD, Nguyen AT, et al. Viral pathogens associated with acute respiratory infections in central vietnamese children. Pediatr Infect Dis J. 2010 Jan. 29(1):75-7. [QxMD MEDLINE Link].

26. Moore HC, Jacoby P, Taylor A, Harnett G, Bowman J, Riley TV, et al. The interaction between respiratory viruses and pathogenic bacteria in the upper respiratory tract of asymptomatic Aboriginal and non-Aboriginal children. Pediatr Infect Dis J. 2010 Jun. 29(6):540-5. [QxMD MEDLINE Link].

27. Moreira LP, Kamikawa J, Watanabe AS, Carraro E, Leal E, Arruda E, et al. Frequency of human rhinovirus species in outpatient children with acute respiratory infections at primary care level in Brazil. Pediatr Infect Dis J. 2011 Jul. 30(7):612-4. [QxMD MEDLINE Link].

28. Mak RK, Tse LY, Lam WY, Wong GW, Chan PK, Leung TF. Clinical spectrum of human rhinovirus infections in hospitalized Hong Kong children. Pediatr Infect Dis J. 2011 Sep. 30(9):749-53. [QxMD MEDLINE Link].

29. Wishaupt JO, Russcher A, Smeets LC, Versteegh FG, Hartwig NG. Clinical impact of RT-PCR for pediatric acute respiratory infections: a controlled clinical trial. Pediatrics. 2011 Nov. 128(5):e1113-20. [QxMD MEDLINE Link].

30. Miller EK, Bugna J, Libster R, Shepherd BE, Scalzo PM, Acosta PL, et al. Human rhinoviruses in severe respiratory disease in very low birth weight infants. Pediatrics. 2012 Jan. 129(1):e60-7. [QxMD MEDLINE Link]. [Full Text].

31. Fry AM, Lu X, Olsen SJ, Chittaganpitch M, Sawatwong P, Chantra S, et al. Human rhinovirus infections in rural Thailand: epidemiological evidence for rhinovirus as both pathogen and bystander. PLoS One. 2011 Mar 29. 6(3):e17780. [QxMD MEDLINE Link]. [Full Text].

32. Miron D, Srugo I, Kra-Oz Z, Keness Y, Wolf D, Amirav I, et al. Sole pathogen in acute bronchiolitis: is there a role for other organisms apart from respiratory syncytial virus?. Pediatr Infect Dis J. 2010 Jan. 29(1):e7-e10. [QxMD MEDLINE Link].

33. O'Callaghan-Gordo C, Bassat Q, Morais L, Díez-Padrisa N, Machevo S, Nhampossa T, et al. Etiology and epidemiology of viral pneumonia among hospitalized children in rural Mozambique: a malaria endemic area with high prevalence of human immunodeficiency virus. Pediatr Infect Dis J. 2011 Jan. 30(1):39-44. [QxMD MEDLINE Link].

34. García-García ML, Calvo C, Pozo F, Villadangos PA, Pérez-Breña P, Casas I. Spectrum of Respiratory Viruses in Children With Community-acquired Pneumonia. Pediatr Infect Dis J. 2012 Aug. 31(8):808-13. [QxMD MEDLINE Link].

35. Louie JK, Roy-Burman A, Guardia-Labar L, Boston EJ, Kiang D, Padilla T, et al. Rhinovirus associated with severe lower respiratory tract infections in children. Pediatr Infect Dis J. 2009 Apr. 28(4):337-9. [QxMD MEDLINE Link].

36. van Piggelen RO, van Loon AM, Krediet TG, Verboon-Maciolek MA. Human rhinovirus causes severe infection in preterm infants. Pediatr Infect Dis J. 2010 Apr. 29(4):364-5. [QxMD MEDLINE Link].

37. Van Leeuwen JC, Goossens LK, Hendrix RM, Van Der Palen J, Lusthusz A, Thio BJ. Equal virulence of rhinovirus and respiratory syncytial virus in infants hospitalized for lower respiratory tract infection. Pediatr Infect Dis J. 2012 Jan. 31(1):84-6. [QxMD MEDLINE Link].

38. García C, Soriano-Fallas A, Lozano J, Leos N, Gomez AM, Ramilo O, et al. Decreased innate immune cytokine responses correlate with disease severity in children with respiratory syncytial virus and human rhinovirus bronchiolitis. Pediatr Infect Dis J. 2012 Jan. 31(1):86-9. [QxMD MEDLINE Link].

39. Hung IF, Zhang AJ, To KK, Chan JF, Zhu SH, Zhang R, et al. Unexpectedly Higher Morbidity and Mortality of Hospitalized Elderly Patients Associated with Rhinovirus Compared with Influenza Virus Respiratory Tract Infection. Int J Mol Sci. 2017 Jan 26. 18 (2):[QxMD MEDLINE Link].

40. Sperber SJ, Shah LP, Gilbert RD, Ritchey TW, Monto AS. Echinacea purpurea for prevention of experimental rhinovirus colds. Clin Infect Dis. 2004 May 15. 38(10):1367-71. [QxMD MEDLINE Link].

41. Calvo C, García-García ML, Blanco C, Pozo F, Flecha IC, Pérez-Breña P. Role of rhinovirus in hospitalized infants with respiratory tract infections in Spain. Pediatr Infect Dis J. 2007 Oct. 26(10):904-8. [QxMD MEDLINE Link].

42. Winther B, McCue K, Ashe K, Rubino JR, Hendley JO. Environmental contamination with rhinovirus and transfer to fingers of healthy individuals by daily life activity. J Med Virol. 2007 Oct. 79(10):1606-10. [QxMD MEDLINE Link].

43. Linsuwanon P, Payungporn S, Samransamruajkit R, Theamboonlers A, Poovorawan Y. Recurrent human rhinovirus infections in infants with refractory wheezing. Emerg Infect Dis. 2009 Jun. 15(6):978-80. [QxMD MEDLINE Link]. [Full Text].

44. Miller EK, Lu X, Erdman DD, Poehling KA, Zhu Y, Griffin MR, et al. Rhinovirus-associated hospitalizations in young children. J Infect Dis. 2007 Mar 15. 195(6):773-81. [QxMD MEDLINE Link].

45. Jackson DJ, Gangnon RE, Evans MD, Roberg KA, Anderson EL, Pappas TE, et al. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med. 2008 Oct 1. 178(7):667-72. [QxMD MEDLINE Link]. [Full Text].

46. Looi K, Troy NM, Garratt LW, Iosifidis T, Bosco A, Buckley AG, et al. Effect of human rhinovirus infection on airway epithelium tight junction protein disassembly and transepithelial permeability. Exp Lung Res. 2016 Oct 11. 1-16. [QxMD MEDLINE Link].

47. Shariff S, Shelfoon C, Holden NS, Traves SL, Wiehler S, Kooi C, et al. Human Rhinovirus Infection of Epithelial Cells Modulates Airway Smooth Muscle Migration. Am J Respir Cell Mol Biol. 2017 Jun. 56 (6):796-803. [QxMD MEDLINE Link].

48. Glanville N, Peel TJ, Schröder A, Aniscenko J, Walton RP, Finotto S, et al. Tbet Deficiency Causes T Helper Cell Dependent Airways Eosinophilia and Mucus Hypersecretion in Response to Rhinovirus Infection. PLoS Pathog. 2016 Sep. 12 (9):e1005913. [QxMD MEDLINE Link].

49. Arden KE, Faux CE, O'Neill NT, McErlean P, Nitsche A, Lambert SB, et al. Molecular characterization and distinguishing features of a novel human rhinovirus (HRV) C, HRVC-QCE, detected in children with fever, cough and wheeze during 2003. J Clin Virol. 2010 Mar. 47(3):219-23. [QxMD MEDLINE Link].

50. Iwane MK, Prill MM, Lu X, Miller EK, Edwards KM, Hall CB, et al. Human rhinovirus species associated with hospitalizations for acute respiratory illness in young US children. J Infect Dis. 2011 Dec 1. 204(11):1702-10. [QxMD MEDLINE Link].

51. Jackson DJ. The role of rhinovirus infections in the development of early childhood asthma. Curr Opin Allergy Clin Immunol. 2010 Apr. 10(2):133-8. [QxMD MEDLINE Link]. [Full Text].

52. Wilkinson TM, Hurst JR, Perera WR, et al. Effect of interactions between lower airway bacterial and rhinoviral infection in exacerbations of COPD. Chest. Feb 2006. 129(2):317-24.

53. Jackson DJ, Gangnon RE, Evans MD, Roberg KA, Anderson EL, Pappas TE, et al. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med. 2008 Oct 1. 178(7):667-72. [QxMD MEDLINE Link]. [Full Text].

54. Gern JE. Rhinovirus and the initiation of asthma. Curr Opin Allergy Clin Immunol. 2009 Feb. 9(1):73-8. [QxMD MEDLINE Link]. [Full Text].

55. Martinez FD. The origins of asthma and chronic obstructive pulmonary disease in early life. Proc Am Thorac Soc. 2009 May 1. 6(3):272-7. [QxMD MEDLINE Link]. [Full Text].

56. Calvo C, Casas I, García-García ML, Pozo F, Reyes N, Cruz N, et al. Role of rhinovirus C respiratory infections in sick and healthy children in Spain. Pediatr Infect Dis J. 2010 Aug. 29(8):717-20. [QxMD MEDLINE Link].

57. Rosenthal LA, Avila PC, Heymann PW, Martin RJ, Miller EK, Papadopoulos NG, et al. Viral respiratory tract infections and asthma: the course ahead. J Allergy Clin Immunol. 2010 Jun. 125(6):1212-7. [QxMD MEDLINE Link]. [Full Text].

58. Olenec JP, Kim WK, Lee WM, Vang F, Pappas TE, Salazar LE, et al. Weekly monitoring of children with asthma for infections and illness during common cold seasons. J Allergy Clin Immunol. 2010 May. 125(5):1001-1006.e1. [QxMD MEDLINE Link]. [Full Text].

59. Busse WW, Lemanske RF Jr, Gern JE. Role of viral respiratory infections in asthma and asthma exacerbations. Lancet. 2010 Sep 4. 376(9743):826-34. [QxMD MEDLINE Link]. [Full Text].

60. Miller EK. New human rhinovirus species and their significance in asthma exacerbation and airway remodeling. Immunol Allergy Clin North Am. 2010 Nov. 30(4):541-52, vii. [QxMD MEDLINE Link]. [Full Text].

61. Johnston SL, Pattemore PK, Sanderson G, Smith S, Lampe F, Josephs L, et al. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ. 1995 May 13. 310(6989):1225-9. [QxMD MEDLINE Link]. [Full Text].

62. Gavala ML, Bertics PJ, Gern JE. Rhinoviruses, allergic inflammation, and asthma. Immunol Rev. 2011 Jul. 242(1):69-90. [QxMD MEDLINE Link]. [Full Text].

63. Guilbert TW, Singh AM, Danov Z, Evans MD, Jackson DJ, Burton R, et al. Decreased lung function after preschool wheezing rhinovirus illnesses in children at risk to develop asthma. J Allergy Clin Immunol. 2011 Sep. 128(3):532-8.e1-10. [QxMD MEDLINE Link]. [Full Text].

64. Jackson DJ, Lemanske RF Jr. The role of respiratory virus infections in childhood asthma inception. Immunol Allergy Clin North Am. 2010 Nov. 30(4):513-22, vi. [QxMD MEDLINE Link]. [Full Text].

65. Jartti T, Korppi M. Rhinovirus-induced bronchiolitis and asthma development. Pediatr Allergy Immunol. 2011 Jun. 22(4):350-5. [QxMD MEDLINE Link].

66. Miller EK, Williams JV, Gebretsadik T, Carroll KN, Dupont WD, Mohamed YA, et al. Host and viral factors associated with severity of human rhinovirus-associated infant respiratory tract illness. J Allergy Clin Immunol. 2011 Apr. 127(4):883-91. [QxMD MEDLINE Link]. [Full Text].

67. Ozcan C, Toyran M, Civelek E, Erkoçoglu M, Altas AB, Albayrak N, et al. Evaluation of respiratory viral pathogens in acute asthma exacerbations during childhood. J Asthma. 2011 Nov. 48(9):888-93. [QxMD MEDLINE Link].

68. Smuts HE, Workman LJ, Zar HJ. Human rhinovirus infection in young African children with acute wheezing. BMC Infect Dis. 2011 Mar 15. 11:65. [QxMD MEDLINE Link]. [Full Text].

69. Peltola V, Heikkinen T, Ruuskanen O, Jartti T, Hovi T, Kilpi T, et al. Temporal association between rhinovirus circulation in the community and invasive pneumococcal disease in children. Pediatr Infect Dis J. 2011 Jun. 30(6):456-61. [QxMD MEDLINE Link].

70. Koponen P, Karjalainen MK, Korppi M. IL10 polymorphisms, rhinovirus-induced bronchiolitis, and childhood asthma. J Allergy Clin Immunol. 2013 Jan. 131(1):249-50. [QxMD MEDLINE Link].

71. Maggini S, Beveridge S, Suter M. A combination of high-dose vitamin C plus zinc for the common cold. J Int Med Res. 2012. 40(1):28-42. [QxMD MEDLINE Link].

72. Ruuskanen O, Lahti E, Jennings LC, Murdoch DR. Viral pneumonia. Lancet. 2011 Apr 9. 377(9773):1264-75. [QxMD MEDLINE Link].

73. Laham FR, Trott AA, Bennett BL, Kozinetz CA, Jewell AM, Garofalo RP, et al. LDH concentration in nasal-wash fluid as a biochemical predictor of bronchiolitis severity. Pediatrics. 2010 Feb. 125(2):e225-33. [QxMD MEDLINE Link]. [Full Text].

74. Jain S, Self WH, Wunderink RG, Fakhran S, Balk R, Bramley AM, et al. Community-Acquired Pneumonia Requiring Hospitalization among U.S. Adults. N Engl J Med. 2015 Jul 30. 373 (5):415-27. [QxMD MEDLINE Link].

75. Reid AB, Anderson TL, Cooley L, Williamson J, Mcgregor AR. An outbreak of human rhinovirus species C infections in a neonatal intensive care unit. Pediatr Infect Dis J. 2011 Dec. 30(12):1096-5. [QxMD MEDLINE Link].

76. Liu Y, Hill MG, Klose T, Chen Z, Watters K, Bochkov YA, et al. Atomic structure of a rhinovirus C, a virus species linked to severe childhood asthma. Proc Natl Acad Sci U S A. 2016 Aug 9. 113 (32):8997-9002. [QxMD MEDLINE Link].

77. Anderson P. High Stroke Risk Transient After Infection in Kids. Medscape Medical News. Available at http://www.medscape.com/viewarticle/830210. Accessed: August 23, 2014.

78. Hills NK, Sidney S, Fullerton HJ. Timing and number of minor infections as risk factors for childhood arterial ischemic stroke. Neurology. 2014 Aug 20. [QxMD MEDLINE Link].

79. Gambarino S, Costa C, Elia M, Sidoti F, Mantovani S, Gruosso V, et al. Development of a RT real-time PCR for the detection and quantification of human rhinoviruses. Mol Biotechnol. 2009 Jul. 42(3):350-7. [QxMD MEDLINE Link].

80. Rogers BB, Shankar P, Jerris RC, Kotzbauer D, Anderson EJ, Watson JR, et al. Impact of a rapid respiratory panel test on patient outcomes. Arch Pathol Lab Med. 2015 May. 139 (5):636-41. [QxMD MEDLINE Link].

81. Chen EC, Miller SA, DeRisi JL, Chiu CY. Using a pan-viral microarray assay (Virochip) to screen clinical samples for viral pathogens. J Vis Exp. 2011 Apr 27. [QxMD MEDLINE Link]. [Full Text].

82. Buecher C, Mardy S, Wang W, Duong V, Vong S, Naughtin M, et al. Use of a multiplex PCR/RT-PCR approach to assess the viral causes of influenza-like illnesses in Cambodia during three consecutive dry seasons. J Med Virol. 2010 Oct. 82(10):1762-72. [QxMD MEDLINE Link].

83. Do DH, Laus S, Leber A, Marcon MJ, Jordan JA, Martin JM, et al. A one-step, real-time PCR assay for rapid detection of rhinovirus. J Mol Diagn. 2010 Jan. 12(1):102-8. [QxMD MEDLINE Link]. [Full Text].

84. Gambarino S, Costa C, Elia M, Sidoti F, Mantovani S, Gruosso V, et al. Development of a RT real-time PCR for the detection and quantification of human rhinoviruses. Mol Biotechnol. 2009 Jul. 42(3):350-7. [QxMD MEDLINE Link].

85. Faux CE, Arden KE, Lambert SB, Nissen MD, Nolan TM, Chang AB, et al. Usefulness of published PCR primers in detecting human rhinovirus infection. Emerg Infect Dis. 2011 Feb. 17(2):296-8. [QxMD MEDLINE Link]. [Full Text].

86. Singh M. Heated, humidified air for the common cold. Cochrane Database Syst Rev. 2004. CD001728. [QxMD MEDLINE Link].

87. To KKW, Yip CCY, Yuen KY. Rhinovirus - From bench to bedside. J Formos Med Assoc. 2017 Jul. 116 (7):496-504. [QxMD MEDLINE Link].

88. Shehab N, Schaefer MK, Kegler SR, Budnitz DS. Adverse events from cough and cold medications after a market withdrawal of products labeled for infants. Pediatrics. 2010 Dec. 126(6):1100-7. [QxMD MEDLINE Link].

89. Hayden FG, Herrington DT, Coats TL, Kim K, Cooper EC, Villano SA, et al. Efficacy and safety of oral pleconaril for treatment of colds due to picornaviruses in adults: results of 2 double-blind, randomized, placebo-controlled trials. Clin Infect Dis. 2003 Jun 15. 36(12):1523-32. [QxMD MEDLINE Link].

90. Singh M, Singh M. Heated, humidified air for the common cold. Cochrane Database Syst Rev. 2013 Jun 4. CD001728. [QxMD MEDLINE Link].

91. Paul IM, Beiler JS, King TS, Clapp ER, Vallati J, Berlin CM Jr. Vapor rub, petrolatum, and no treatment for children with nocturnal cough and cold symptoms. Pediatrics. 2010 Dec. 126(6):1092-9. [QxMD MEDLINE Link].

92. Infant deaths associated with cough and cold medications--two states, 2005. MMWR Morb Mortal Wkly Rep. 2007 Jan 12. 56(1):1-4. [QxMD MEDLINE Link].

93. Calvo C, Garcia ML, Pozo F, Reyes N, Pérez-Breña P, Casas I. Role of rhinovirus C in apparently life-threatening events in infants, Spain. Emerg Infect Dis. 2009 Sep. 15(9):1506-8. [QxMD MEDLINE Link]. [Full Text].

94. De Sutter AI, Saraswat A, van Driel ML. Antihistamines for the common cold. Cochrane Database Syst Rev. 2015 Nov 29. CD009345. [QxMD MEDLINE Link].

95. Science M, Johnstone J, Roth DE, Guyatt G, Loeb M. Zinc for the treatment of the common cold: a systematic review and meta-analysis of randomized controlled trials. CMAJ. 2012 Jul 10. 184 (10):E551-61. [QxMD MEDLINE Link].

96. Eby GA. Therapeutic Effectiveness of Ionic Zinc for Common Colds. Clinical Infectious Diseases. 01 February 2008. 46(3):483-384.

97. Caruso TJ, Prober CG, Gwaltney JM Jr. Treatment of naturally acquired common colds with zinc: a structured review. Clin Infect Dis. 2007 Sep 1. 45 (5):569-74. [QxMD MEDLINE Link].

98. Singh M, Das RR. Zinc for the common cold. Cochrane Database Syst Rev. 2011 Feb 16. CD001364. [QxMD MEDLINE Link].

99. Singh M, Das RR. Zinc for the common cold. Cochrane Database Syst Rev. 2013 Jun 18. CD001364. [QxMD MEDLINE Link].

100. Ronald B. Turner. 57. The Common Cold. Edited by John E. Bennett, MD, Raphael Dolin, MD and Martin J. Blaser, MD. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 8th edition. Philadelphia: Saunders, an imprint of Elsevier Inc.; 2015. 748-752.

101. Saper RB, Rash R. Zinc: an essential micronutrient. Am Fam Physician. 2009 May 1. 79 (9):768-72. [QxMD MEDLINE Link].

102. Gwaltney JM Jr, Winther B, Patrie JT, Hendley JO. Combined antiviral-antimediator treatment for the common cold. J Infect Dis. 2002 Jul 15. 186(2):147-54. [QxMD MEDLINE Link].

103. Hayward G, Thompson MJ, Perera R, Del Mar CB, Glasziou PP, Heneghan CJ. Corticosteroids for the common cold. Cochrane Database Syst Rev. 2015 Oct 13. CD008116. [QxMD MEDLINE Link].

104. Jartti T, Lehtinen P, Vanto T, Hartiala J, Vuorinen T, Mäkelä MJ, et al. Evaluation of the efficacy of prednisolone in early wheezing induced by rhinovirus or respiratory syncytial virus. Pediatr Infect Dis J. 2006 Jun. 25(6):482-8. [QxMD MEDLINE Link].

105. Schwitzer G. How the media left the evidence out in the cold. BMJ. 2003. 326:1403e4.

106. Turner RB, Wecker MT, Pohl G, Witek TJ, McNally E, St George R, et al. Efficacy of tremacamra, a soluble intercellular adhesion molecule 1, for experimental rhinovirus infection: a randomized clinical trial. JAMA. 1999 May 19. 281(19):1797-804. [QxMD MEDLINE Link].

107. Akoto C, Davies DE, Swindle EJ. Mast cells are permissive for rhinovirus replication: potential implications for asthma exacerbations. Clin Exp Allergy. 2017 Mar. 47 (3):351-360. [QxMD MEDLINE Link].

108. Han M, Hong JY, Jaipalli S, Rajput C, Lei J, Hinde JL, et al. IFN-γ Blocks Development of an Asthma Phenotype in Rhinovirus-Infected Baby Mice by Inhibiting Type 2 Innate Lymphoid Cells. Am J Respir Cell Mol Biol. 2017 Feb. 56 (2):242-251. [QxMD MEDLINE Link].

109. Hayden FG, Turner RB, Gwaltney JM, Chi-Burris K, Gersten M, Hsyu P, et al. Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers. Antimicrob Agents Chemother. 2003 Dec. 47(12):3907-16. [QxMD MEDLINE Link]. [Full Text].

110. Gern JE, Mosser AG, Swenson CA, Rennie PJ, England RJ, Shaffer J, et al. Inhibition of rhinovirus replication in vitro and in vivo by acid-buffered saline. J Infect Dis. 2007 Apr 15. 195(8):1137-43. [QxMD MEDLINE Link].

111. Schwartz AR, Togo Y, Hornick RB, Tominaga S, Gleckman RA. Evaluation of the efficacy of ascorbic acid in prophylaxis of induced rhinovirus 44 infection in man. J Infect Dis. 1973 Oct. 128(4):500-5. [QxMD MEDLINE Link].

112. Guedán A, Swieboda D, Charles M, Toussaint M, Johnston SL, Asfor A, et al. Investigation of the Role of Protein Kinase D in Human Rhinovirus Replication. J Virol. 2017 May 1. 91 (9):[QxMD MEDLINE Link].

113. Berman R, Jiang D, Wu Q, Chu HW. α1-Antitrypsin reduces rhinovirus infection in primary human airway epithelial cells exposed to cigarette smoke. Int J Chron Obstruct Pulmon Dis. 2016. 11:1279-86. [QxMD MEDLINE Link].

114. Lee JJ, Shim A, Jeong JY, Lee SY, Ko HJ, Cho HJ. Development of intranasal nanovehicles of itraconazole and their immunological activities for the therapy of rhinovirus infection. Colloids Surf B Biointerfaces. 2016 Jul 1. 143:336-41. [QxMD MEDLINE Link].

115. Shim A, Song JH, Kwon BE, Lee JJ, Ahn JH, Kim YJ, et al. Therapeutic and prophylactic activity of itraconazole against human rhinovirus infection in a murine model. Sci Rep. 2016 Mar 15. 6:23110. [QxMD MEDLINE Link].

116. Stokes CA, Kaur R, Edwards MR, Mondhe M, Robinson D, Prestwich EC, et al. Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes. Mucosal Immunol. 2016 Sep. 9 (5):1303-16. [QxMD MEDLINE Link].

117. Cagno V, Civra A, Kumar R, Pradhan S, Donalisio M, Sinha BN, et al. Ficus religiosa L. bark extracts inhibit human rhinovirus and respiratory syncytial virus infection in vitro. J Ethnopharmacol. 2015 Dec 24. 176:252-7. [QxMD MEDLINE Link].

118. Hemilä H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2013 Jan 31. CD000980. [QxMD MEDLINE Link].

119. Turner RB, Bauer R, Woelkart K, Hulsey TC, Gangemi JD. An evaluation of Echinacea angustifolia in experimental rhinovirus infections. N Engl J Med. 2005 Jul 28. 353(4):341-8. [QxMD MEDLINE Link].

120. Schoop R, Klein P, Suter A, Johnston SL. Echinacea in the prevention of induced rhinovirus colds: a meta-analysis. Clin Ther. 2006 Feb. 28(2):174-83. [QxMD MEDLINE Link].

121. Barrett B, Brown R, Rakel D, Mundt M, Bone K, Barlow S, et al. Echinacea for treating the common cold: a randomized trial. Ann Intern Med. 2010 Dec 21. 153(12):769-77. [QxMD MEDLINE Link]. [Full Text].

122. Turner RB, Biedermann KA, Morgan JM, Keswick B, Ertel KD, Barker MF. Efficacy of organic acids in hand cleansers for prevention of rhinovirus infections. Antimicrob Agents Chemother. 2004 Jul. 48(7):2595-8. [QxMD MEDLINE Link]. [Full Text].

123. Halperin SA, Eggleston PA, Beasley P, Suratt P, Hendley JO, Gröschel DH, et al. Exacerbations of asthma in adults during experimental rhinovirus infection. Am Rev Respir Dis. 1985 Nov. 132(5):976-80. [QxMD MEDLINE Link].

124. Pappas DE, Hendley JO, Hayden FG, Winther B. Symptom profile of common colds in school-aged children. Pediatr Infect Dis J. 2008 Jan. 27(1):8-11. [QxMD MEDLINE Link].

125. Singh M, Das RR. Zinc for the common cold. Cochrane Database Syst Rev. 2011 Feb 16. CD001364. [QxMD MEDLINE Link].

126. Costa LF, Queiróz DA, da Silveira HL, Neto MB, de Paula NT, Oliveira TF, et al. Human Rhinovirus and Disease Severity in Children. Pediatrics. 2014 Jan 13. [QxMD MEDLINE Link].

127. De Sutter AI, van Driel ML, Kumar AA, Lesslar O, Skrt A. Oral antihistamine-decongestant-analgesic combinations for the common cold. Cochrane Database Syst Rev. 2012 Feb 15. 2:CD004976. [QxMD MEDLINE Link].

128. Fox S. Severe Pediatric Rhinovirus Linked to RSV Coinfections. Available at http://www.medscape.com/viewarticle/819204. Accessed: January 19, 2014.

129. Linder JE, Kraft DC, Mohamed Y, Lu Z, Heil L, Tollefson S, et al. Human rhinovirus C: Age, season, and lower respiratory illness over the past 3 decades. J Allergy Clin Immunol. 2013 Jan. 131(1):69-77.e1-6. [QxMD MEDLINE Link].

Joseph Adrian L Buensalido, MD Clinical Associate Professor, Division of Infectious Diseases, Department of Medicine, Philippine General Hospital, University of the Philippines Manila College of Medicine; Specialist in Infectious Diseases, Private Practice

Joseph Adrian L Buensalido, MD is a member of the following medical societies: American Society for Microbiology, Infectious Diseases Society of America, Michigan Infectious Disease Society, Philippine College of Physicians, Philippine Medical Association, Philippine Society for Microbiology and Infectious Diseases

Disclosure: Serve(d) as a speaker or a member of a speakers bureau for: Unilab; BSV Bioscience; Philcare Pharma<br/>Received sponsorship to medical conference for: Pfizer; Natrapharm.

Jose Carlo B Valencia, MD Medical Specialist III, Department of Medicine, Cagayan Valley Medical Center, Philippines

Jose Carlo B Valencia, MD is a member of the following medical societies: Philippine College of Physicians, Philippine Medical Association, Philippine Society for Microbiology and Infectious Diseases

Disclosure: Nothing to disclose.

John L Brusch, MD, FACP Corresponding Faculty Member, Harvard Medical School

John L Brusch, MD, FACP is a member of the following medical societies: American College of Physicians, Infectious Diseases Society of America

Disclosure: Nothing to disclose.

Michael Rajnik, MD Associate Professor, Department of Pediatrics, Program Director, Pediatric Infectious Disease Fellowship Program, Uniformed Services University of the Health Sciences

Michael Rajnik, MD is a member of the following medical societies: American Academy of Pediatrics, Infectious Diseases Society of America, Pediatric Infectious Diseases Society, Armed Forces Infectious Diseases Society

Disclosure: Nothing to disclose.

Duane R Hospenthal, MD, PhD Professor of Medicine, Uniformed Services University of the Health Sciences; Physician, Infectious Disease Service, San Antonio Military Medical Center (formerly Brooke Army Medical Center)

Duane R Hospenthal, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians, American Society for Microbiology, American Society of Tropical Medicine and Hygiene, Armed Forces Infectious Diseases Society, Association of Military Surgeons of the US, Infectious Diseases Society of America, International Society for Human and Animal Mycology, International Society for Infectious Diseases, International Society of Travel Medicine, and Medical Mycology Society of the Americas

Disclosure: Nothing to disclose.

James D Korb, MD Program Director, Department of Pediatrics, Children's Hospital of Orange County

Disclosure: Nothing to disclose.

Larry I Lutwick, MD Professor of Medicine, State University of New York Downstate Medical School; Director, Infectious Diseases, Veterans Affairs New York Harbor Health Care System, Brooklyn Campus

Larry I Lutwick, MD is a member of the following medical societies: American College of Physicians and Infectious Diseases Society of America

Disclosure: Nothing to disclose.

Clinton Murray, MD

Program Director, Infectious Disease Fellowship, San Antonio Uniformed Services Health Education Consortium

Clinton Murray, MD is a member of the following medical societies: American College of Physicians-American Society of Internal Medicine, American Medical Association, American Society for Microbiology, American Society of Tropical Medicine and Hygiene, Association of Military Surgeons of the US, and Infectious Diseases Society of America

Disclosure: Nothing to disclose.

Mai Ngoc Nguyen, MD

Staff Physician, Department of Pediatrics, Mattel Children's Hospital, University of California at Los Angeles

Mai Ngoc Nguyen, MD is a member of the following medical societies: American Academy of Pediatrics, and American Medical Association

Disclosure: Nothing to disclose.

José Rafael Romero, MD Director of Pediatric Infectious Diseases Fellowship Program, Associate Professor, Department of Pediatrics, Combined Division of Pediatric Infectious Diseases, Creighton University/University of Nebraska Medical Center

José Rafael Romero, MD is a member of the following medical societies: American Academy of Pediatrics, American Society for Microbiology, Infectious Diseases Society of America, New York Academy of Sciences, and Pediatric Infectious Diseases Society

Disclosure: Nothing to disclose.

Gregory William Rutecki MD Professor of Medicine, University of South Alabama Medical School

Gregory William Rutecki is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians, American Society of Nephrology, National Kidney Foundation, and Society of General Internal Medicine

Disclosure: Nothing to disclose.

Russell W Steele, MD Head, Division of Pediatric Infectious Diseases, Ochsner Children's Health Center; Clinical Professor, Department of Pediatrics, Tulane University School of Medicine

Russell W Steele, MD is a member of the following medical societies: American Academy of Pediatrics, American Association of Immunologists, American Pediatric Society, American Society for Microbiology, Infectious Diseases Society of America, Louisiana State Medical Society, Pediatric Infectious Diseases Society, Society for Pediatric Research, and Southern Medical Association

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Salary Employment

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Gordon L Woods, MD Consulting Staff, Department of Internal Medicine, University Medical Center

Gordon L Woods, MD is a member of the following medical societies: Society of General Internal Medicine

Disclosure: Nothing to disclose.

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