Salmonella Infection (Salmonellosis) Questions & Answers

1. Kim AY, Goldberg MB, Rubin RH. Salmonella infections. Gorbach SL, Bartlett JG, Blacklow NR, eds. Infectious Diseases. 3rd ed. Lippincott Williams and Wilkins; 2004. 68.

2. Hohmann EL. Nontyphoidal salmonellosis. Clin Infect Dis. 2001 Jan 15. 32(2):263-9. [QxMD MEDLINE Link].

3. Su LH, Chiu CH. Salmonella: clinical importance and evolution of nomenclature. Chang Gung Med J. May-Jun 2007. 30 (3):210-9. [QxMD MEDLINE Link].

4. Brenner FW, Villar RG, Angulo FJ, Tauxe R, Swaminathan B. Salmonella nomenclature. J Clin Microbiol. 2000 Jul. 38(7):2465-7. [QxMD MEDLINE Link].

5. Grassl GA, Finlay BB. Pathogenesis of enteric Salmonella infections. Curr Opin Gastroenterol. 2008 Jan. 24(1):22-6. [QxMD MEDLINE Link].

6. Kurtz JR, Goggins JA, McLachlan JB. Salmonella infection: Interplay between the bacteria and host immune system. Immunol Lett. 2017 Oct. 190:42-50. [QxMD MEDLINE Link]. [Full Text].

7. World Health Organization Communicable Disease Surveilance and Response. Vaccines and Biologicals. Background document: The diagnosis, treatment and prevention of typhoid fever. Available at http://www.who.int/vaccines-documents/DocsPDF03/www740.pdf. Accessed: 10/29/08.

8. Meltzer E, Schwartz E. Enteric fever: an Israeli perspective. Isr Med Assoc J. 2007 Oct. 9(10):736-41. [QxMD MEDLINE Link].

9. Centers for Disease Control and Prevention (CDC). Notes from the field: Human Salmonella infantis infections linked to dry dog food--United States and Canada, 2012. MMWR Morb Mortal Wkly Rep. 2012 Jun 15. 61(23):436. [QxMD MEDLINE Link].

10. Yeh Y, Purushothaman P, Gupta N, Ragnone M, Verma SC, de Mello AS. Bacteriophage application on red meats and poultry: Effects on Salmonella population in final ground products. Meat Sci. 2017 May. 127:30-34. [QxMD MEDLINE Link]. [Full Text].

11. Kore K, Asrade B, Demissie K, Aragaw K. Characterization of Salmonella isolated from apparently healthy slaughtered cattle and retail beef in Hawassa, southern Ethiopia. Prev Vet Med. 2017 Nov 1. 147:11-16. [QxMD MEDLINE Link]. [Full Text].

12. Investigation of outbreak of infections caused by Salmonella saintpaul. Update for August 2008. Available at http://www.cdc.gov/salmonella/saintpaul/. Accessed: 10/29/2008.

13. Crum-Cianflone NF. Salmonellosis and the gastrointestinal tract: more than just peanut butter. Curr Gastroenterol Rep. Aug 2008. 10 (4):424-31. [QxMD MEDLINE Link].

14. Brouard C, Espie E, Well FX , Kerouanton A, Brisabois A, Forgue AM, et al. Two consequtive large outbreaks of Salmonella enterica serotype Agona infections in infants linked to the consumption of powdered infant formula. Pediatr Infect Dis J. Feb 2007. 26(2):148-52. [QxMD MEDLINE Link].

15. Centers for Disease Control and Prevention. From the Centers for Disease Control and Prevention. African pygmy hedgehog-associated salmonellosis--Washington, 1994. JAMA. 1995 Jul 26. 274(4):294. [QxMD MEDLINE Link].

16. Mermin J, Hutwagner L, Vugia D, et al. Reptiles, amphibians, and human Salmonella infection: a population-based, case-control study. Clin Infect Dis. 2004 Apr 15. 38 Suppl 3:S253-61. [QxMD MEDLINE Link].

17. Outbreaks of multidrug-resistant Salmonella typhimurium associated with veterinary facilities--Idaho, Minnesota, and Washington, 1999. MMWR Morb Mortal Wkly Rep. 2001 Aug 24. 50(33):701-4. [QxMD MEDLINE Link]. [Full Text].

18. Reptile-associated salmonellosis--selected states, 1998-2002. MMWR Morb Mortal Wkly Rep. 2003 Dec 12. 52(49):1206-9. [QxMD MEDLINE Link]. [Full Text].

19. Salmonellosis associated with chicks and ducklings--Michigan and Missouri, Spring 1999. MMWR Morb Mortal Wkly Rep. 2000 Apr 14. 49(14):297-9. [QxMD MEDLINE Link]. [Full Text].

20. Woodward DL, Khakhria R, Johnson WM. Human salmonellosis associated with exotic pets. J Clin Microbiol. 1997 Nov. 35(11):2786-90. [QxMD MEDLINE Link]. [Full Text].

21. Swanson SJ, Snider C, Braden CR, Boxrud D, Wunschmann A, Rudroff JA, et al. Multidrug resistant salmonella enterica serotype Typhimurium associated with pet rodents. N Engl J Med. January 4, 2007. 356:21-8. [QxMD MEDLINE Link]. [Full Text].

22. Centers for Disease Control and Prevention. Preliminary FoodNet data on the incidence of infection with pathogens transmitted commonly through food--10 states, 2007. MMWR Morb Mortal Wkly Rep. 2008 Apr 11. 57(14):366-70. [QxMD MEDLINE Link].

23. Voetsch AC, Van Gilder TJ, Angulo FJ, Farley MM, Shallow S, Marcus R, et al. FoodNet estimate of the burden of illness caused by nontyphoidal Salmonella infections in the United States. Clin Infect Dis. 2004 Apr 15. 38 Suppl 3:S127-34. [QxMD MEDLINE Link].

24. Cavallaro E, Date K, Medus C, Meyer S, Miller B, Kim C, et al. Salmonella typhimurium infections associated with peanut products. N Engl J Med. 2011 Aug 18. 365(7):601-10. [QxMD MEDLINE Link].

25. Linam WM, Gerber MA. Changing epidemiology and prevention of Salmonella infections. Pediatr Infect Dis J. 2007 Aug. 26(8):747-8. [QxMD MEDLINE Link].

26. Crump JA, Luby SP, Mintz ED. The global burden of typhoid fever. Bull World Health Organ. May 2004. 82 (5):346-53. [QxMD MEDLINE Link].

27. Bhan MK, Bahl R, Bhatnagar S. Typhoid and parattyphoid fever. Lancet. Aug 2005. 366:749-62. [QxMD MEDLINE Link]. [Full Text].

28. Hathout S el-D. Relation of schistosomiasis to typhoid fever. J Egypt Public Health Assoc. 45. 1970:145-56. [QxMD MEDLINE Link].

29. Akhaddar A, Hall W, Boucetta M. Subgaleal and brain abscesses due to Salmonella enteritidis following craniotomy for giant cell glioblastoma multiforme: A case report and literature review. Surg Neurol Int. 2019. 10:37. [QxMD MEDLINE Link].

30. Luciani L, Dubourg G, Graillon T, Honnorat E, Lepidi H, Drancourt M, et al. Salmonella enterica serovar Enteritidis brain abscess mimicking meningitis after surgery for glioblastoma multiforme: a case report and review of the literature. J Med Case Rep. 2016 Jul 7. 10:192. [QxMD MEDLINE Link].

31. Gardini G, Zanotti P, Pucci A, Tomasoni L, Caligaris S, Paro B, et al. Non-typhoidal Salmonella aortitis. Infection. 2019 Dec. 47 (6):1059-1063. [QxMD MEDLINE Link].

32. Ikejiri K, Suzuki K, Ito A, Yasuda K, Shindo A, Ishikura K, et al. Invasive Salmonella Enteritidis infection complicated by bacterial meningitis and vertebral osteomyelitis shortly after influenza A infection in an immunocompetent young adult. J Infect Chemother. 2019 Aug 21. pii: S1341-321X(19)30235-1. doi: 10.1016/j.jiac.2019.08.001. [Epub ahead of print]. [QxMD MEDLINE Link].

33. Fukushima K, Yanagisawa N, Sekiya N, Izumiya H. Bacteremia Caused by Salmonella Poona in a Healthy Adult in Tokyo, Japan. Intern Med. 2019 Sep 18. doi: 10.2169/internalmedicine[Epub ahead of print]:3161-19. [QxMD MEDLINE Link].

34. Bhutta ZA. Impact of age and drug resistance on mortality in typhoid fever. Arch Dis Child. 1996. 75:214-7. [QxMD MEDLINE Link]. [Full Text].

35. Ali G, Rashid S, Kamli MA, Shah PA, Allaqaband GQ. Spectrum of neuropsychiatric complications in 791 cases of typhoid fever. Trop Med Int Health. 1997. 2:314-318. [QxMD MEDLINE Link].

36. Prabha A, Mohanan, Pereira P, Raghuveer CV. Myocarditis in enteric fever. Indian J Med Sci. 1995. 49:28-31. [QxMD MEDLINE Link].

37. Zha L, Garrett S, Sun J. Salmonella Infection in Chronic Inflammation and Gastrointestinal Cancer. Diseases. 2019 Mar 10. 7 (1):28. [QxMD MEDLINE Link].

38. Gasem MH, Keuter M, Dolmans WM, Van DerVen-Jongekriig J, Djokomoeljanto R, Van Der Meer JW. Persistence of Salmonellae in blood and bone marrow randomized controlled trial comparing ciprofloxacin and chloramphenicol treatment against enteric fever. Antimicrob Agents Chemother. May 2003. 47:1727-31. [QxMD MEDLINE Link]. [Full Text].

39. Dekker JP, Frank KM. Salmonella, Shigella, and yersinia. Clin Lab Med. 2015 Jun. 35 (2):225-46. [QxMD MEDLINE Link].

40. Nakamura S, Iida M, Tominaga M, et al. Salmonella colitis: Assessment with double-contrast barium enema examination in seven patients. Radiology. Aug/1992. 184:537-540. [QxMD MEDLINE Link].

41. Balthazar EJ, Charles HW, Megibow AJ. Salmonella- and shigella-induced ileitis: CT findings in four patients. J Comput Assist Tomogr. May/1996. 20:375-378. [QxMD MEDLINE Link].

42. Puylaert JB, Van der Zant FM, Mutsaers JA. Infectious ileocecitis caused by Yersinia, Campylobacter, and Salmonella: clinical, radiological and US findings. Eur Radiol. 1997. 7(1):3-9. [QxMD MEDLINE Link].

43. Lee WK, Mossop PJ, Little AF, et al. Infected (mycotic) aneurysms: spectrum of imaging appearances and management. Radiographics. 2008 Nov-Dec. 28(7):1853-68. [QxMD MEDLINE Link].

44. Bhutta ZA. Current concepts in the diagnosis and treatment of typhoid fever. BMJ. Jul 2006. 333:78-82. [QxMD MEDLINE Link]. [Full Text].

45. Shirakava T, Acarya B, Kinoshita S, Kumagai S, Gotoh A, Kawabata M. Decreased susceptibility to fluoroquinolones and gyrA gene mutation in the Salmonella enterica serovar Typhi and Paratyphi A isolated in Kathmandu, Nepal, in 2003. Diagn Microbiol Infect Dis. Apr 2006. 54:299-303. [QxMD MEDLINE Link].

46. Crump JA, Medalla FM, Joyce KW, Krueger AL, Hoekstra RM, Whichard JM, et al. Antimicrobial resistance among invasive nontyphoidal Salmonella enterica isolates in the United States: National Antimicrobial Resistance Monitoring System, 1996 to 2007. Antimicrob Agents Chemother. 2011 Mar. 55(3):1148-54. [QxMD MEDLINE Link].

47. Ercis S, Erdem B, Hasçelik G, Gür D. Nalidixic acid resistance in Salmonella strains with decreased susceptibility to ciprofloxacin isolated from humans in Turkey. Jpn J Infect Dis. 2006 Apr. 59(2):117-9. [QxMD MEDLINE Link]. [Full Text].

48. Hakanen A, Kotilanien P, Jalava J, et al. Detection of decreased fluoroquinolone susceptibility in Sal.onella and validation of nalidixic acid screening test. J Clin Microbiol. 1999. 37:3572-77. [QxMD MEDLINE Link]. [Full Text].

49. Beeching NJ, Parry CM. Outpatient treatment of patients with enteric fever. Lancet Infect Dis. 2011 Jun. 11(6):419-21. [QxMD MEDLINE Link].

50. Coughlin LB, McGuigan J, Haddad NG, Mannion P. Salmonella sepsis and miscarriage. Clin Microbiol Infect. 2003 Aug. 9(8):866-8. [QxMD MEDLINE Link].

51. Gyang A, Saunders M. Salmonella Mississippi: a rare cause of second trimester miscarriage. Arch Gynecol Obstet. 2008 May. 277(5):437-8. [QxMD MEDLINE Link].

52. Oskoui R, Davis W, Gomez M. Salmonella aortitis: a report of successfully treated case with a comprehensive review of the literature. Arch Intern Med. Feb 1993. 153:517-25. [QxMD MEDLINE Link].

53. Nunes AP, Marques A, Marchado C, Meirelaes N, Sobrinho G, et al. Tiphymurium Salmonella Aortitis. Rev Port Cir Cardiotorac Vasc. Jul-Sept 2007. 14:167-71. [QxMD MEDLINE Link].

54. [Guideline] World Health Organization (WHO). Guidelines on the quality, safety and efficacy of typhoid conjugate vaccines. Available at: http://www.who.int/biologicals/areas/vaccines/TYPHOID_BS2215_doc_v1.14_WEB_VERSION.pdf?ua=1&ua=1. 2013; Accessed: November 16, 2019.

55. Fraser A, Goldberg E, Acosta CJ, Paul M, Leibovici L. Vaccines for preventing typhoid fever. Cochrane Database Syst Rev. Jul 2007. 3:CD001261. [QxMD MEDLINE Link].

56. Szu SC. Development of Vi conjugate - a new generation of typhoid vaccine. Expert Rev Vaccines. 2013 Nov. 12 (11):1273-86. [QxMD MEDLINE Link].

57. Chen PL, Lee CC, Li CY, et al. A simple scoring algorithm predicting vascular infections in adults with nontyphoid Salmonella bacteremia. Clin Infect Dis. 2012 Jul. 55(2):194-200. [QxMD MEDLINE Link].

58. Workman MR, Philpott-Howard J, Bragman S, Brito-Babapulle F, Bellingham AJ. Emergence of ciprofloxacin resistance during treatment of Salmonella osteomyelitis in three patients with sickle cell disease. J Infect. 1996 Jan. 32(1):27-32. [QxMD MEDLINE Link].

59. Berkley JA, Lowe BS, Mwangi I, Williams T, Bauni E, Mwarumba S, et al. Bacteremia among children admitted to a rural hospital in Kenya. N Engl J Med. 2005 Jan 6. 352(1):39-47. [QxMD MEDLINE Link].

60. Sinha A, Sazawal S, Kumar R, Sood S, Reddaiah VP, Singh B, et al. Typhoid fever in children aged less than 5 years. Lancet. 1999 Aug 28. 354(9180):734-7. [QxMD MEDLINE Link].

61. Crum-Cianflone NF. Salmonellosis and the gastrointestinal tract: more than just peanut butter. Curr Gastroenterol Rep. Aug 2008. 10 (4):424-31. [QxMD MEDLINE Link].

62. Miller SI, Pegues DA. Salmonella species, including Salmonella typhi. Mandell, et al, ed. Principles and Practices of Infectious Diseases. 5th ed. 2000. Vol 2: 2344-62.

63. Schroeder CM, Naugle AL, Schlosser WD, et al. Estimate of illnesses from Salmonella enteritidis in eggs, United States, 2000. Emerg Infect Dis. 2005 Jan. 11(1):113-5. [QxMD MEDLINE Link].

64. Freeman R, Dabrera G, Lane C, Adams N, Browning L, Fowler T, et al. Association between use of proton pump inhibitors and non-typhoidal salmonellosis identified following investigation into an outbreak of Salmonella Mikawasima in the UK, 2013. Epidemiol Infect. 2015 Oct 1. 1-8. [QxMD MEDLINE Link].

65. Williams S, Markey P, Harlock M, Binns P, Gaggin J, Patel M. Individual and household-level risk factors for sporadic salmonellosis in children. J Infect. 2015 Sep 28. [QxMD MEDLINE Link].

Alena Klochko, MD Infectious Disease Physician, Orlando Health, Florida

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

John L Brusch, MD, FACP Corresponding Faculty Member, Harvard Medical School

John L Brusch, MD, FACP is a member of the following medical societies: American College of Physicians, Infectious Diseases Society of America

Disclosure: Nothing to disclose.

Michael Stuart Bronze, MD David Ross Boyd Professor and Chairman, Department of Medicine, Stewart G Wolf Endowed Chair in Internal Medicine, Department of Medicine, University of Oklahoma Health Science Center; Master of the American College of Physicians; Fellow, Infectious Diseases Society of America; Fellow of the Royal College of Physicians, London

Michael Stuart Bronze, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians, American Medical Association, Association of Professors of Medicine, Infectious Diseases Society of America, Oklahoma State Medical Association, Southern Society for Clinical Investigation

Disclosure: Nothing to disclose.

Mark R Wallace, MD, FACP, FIDSA Infectious Disease Physician, Skagit Valley Hospital, Skagit Regional Health

Disclosure: Nothing to disclose.

Mary D Nettleman, MD, MS, MACP Professor and Chair, Department of Medicine, Michigan State University College of Human Medicine

Mary D Nettleman, MD, MS, MACP is a member of the following medical societies: American College of Physicians, Association of Professors of Medicine, Central Society for Clinical and Translational Research, Infectious Diseases Society of America, Society of General Internal Medicine

Disclosure: Nothing to disclose.

The authors and editors of Medscape Reference gratefully acknowledge the contributions of previous author Michael Zapor, MD, PhD, and previous coauthor David P Dooley, MD, to the development and writing of this article.

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