African Trypanosomiasis Differential Diagnoses

Updated: Apr 11, 2016
  • Author: Randy O Odero, MB, ChB; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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DDx

Diagnostic Considerations

In stage 1 (early or hemolymphatic stage) African trypanosomiasis (sleeping sickness), differential diagnoses of recurrent fever include malaria, HIV infection, borreliosis, brucellosis, typhoid fever, and other enteric fevers. Differential diagnoses of lymphadenopathy include tuberculosis (TB) lymphadenitis, HIV infection, and cancer. In stage 2 (late or neurologic stage) African trypanosomiasis, differential diagnoses of mental status changes include TB, meningitis, and HIV-related opportunistic infections, including cryptococcal meningitis.

Differentials

Brucellosis

Cryptococcal Meningitis

HIV Infection

Malaria

Meningitis

Tuberculosis

Typhoid Fever