Group B Streptococcus (GBS) Infections Questions & Answers

1. Nandyal RR. Update on group B streptococcal infections: perinatal and neonatal periods. J Perinat Neonatal Nurs. 2008 Jul-Sep. 22(3):230-7. [QxMD MEDLINE Link].

2. Nanduri SA, Petit S, Smelser C, Apostol M, Alden NB, Harrison LH, et al. Epidemiology of Invasive Early-Onset and Late-Onset Group B Streptococcal Disease in the United States, 2006 to 2015: Multistate Laboratory and Population-Based Surveillance. JAMA Pediatr. 2019 Mar 1. 173 (3):224-233. [QxMD MEDLINE Link].

3. [Guideline] Prevention of Group B Streptococcal Early-Onset Disease in Newborns: ACOG Committee Opinion, Number 797. Obstet Gynecol. 2020 Feb. 135 (2):e51-e72. [QxMD MEDLINE Link].

4. Verani JR, McGee L, Schrag SJ, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention (CDC). Prevention of perinatal group B streptococcal disease--revised guidelines from CDC, 2010. MMWR Recomm Rep. 2010 Nov 19. 59 (RR-10):1-36. [QxMD MEDLINE Link].

5. Back EE, O'Grady EJ, Back JD. High rates of perinatal group B Streptococcus clindamycin and erythromycin resistance in an upstate New York hospital. Antimicrob Agents Chemother. 2012 Feb. 56 (2):739-42. [QxMD MEDLINE Link].

6. Huang PY, Lee MH, Yang CC, Leu HS. Group B streptococcal bacteremia in non-pregnant adults. J Microbiol Immunol Infect. 2006 Jun. 39(3):237-41. [QxMD MEDLINE Link].

7. Jackson LA, Hilsdon R, Farley MM, Harrison LH, Reingold AL, Plikaytis BD, et al. Risk factors for group B streptococcal disease in adults. Ann Intern Med. 1995 Sep 15. 123 (6):415-20. [QxMD MEDLINE Link].

8. Sendi P, Johansson L, Norrby-Teglund A. Invasive group B Streptococcal disease in non-pregnant adults : a review with emphasis on skin and soft-tissue infections. Infection. 2008 Mar. 36(2):100-11. [QxMD MEDLINE Link].

9. Raabe VN, Shane AL. Group B Streptococcus (Streptococcus agalactiae). Microbiol Spectr. 2019 Mar. 7 (2):[QxMD MEDLINE Link].

10. Phares CR, Lynfield R, Farley MM, Mohle-Boetani J, Harrison LH, Petit S, et al. Epidemiology of invasive group B streptococcal disease in the United States, 1999-2005. JAMA. 2008 May 7. 299(17):2056-65. [QxMD MEDLINE Link].

11. Schrag SJ, Verani JR. Intrapartum antibiotic prophylaxis for the prevention of perinatal group B streptococcal disease: experience in the United States and implications for a potential group B streptococcal vaccine. Vaccine. 2013 Aug 28. 31 Suppl 4:D20-6. [QxMD MEDLINE Link].

12. Francois Watkins LK, McGee L, Schrag SJ, Beall B, Jain JH, Pondo T, et al. Epidemiology of Invasive Group B Streptococcal Infections Among Nonpregnant Adults in the United States, 2008-2016. JAMA Intern Med. 2019 Apr 1. 179 (4):479-488. [QxMD MEDLINE Link].

13. Madrid L, Seale AC, Kohli-Lynch M, Edmond KM, Lawn JE, Heath PT, et al. Infant Group B Streptococcal Disease Incidence and Serotypes Worldwide: Systematic Review and Meta-analyses. Clin Infect Dis. 2017 Nov 6. 65 (suppl_2):S160-S172. [QxMD MEDLINE Link].

14. Gardam MA, Low DE, Saginur R. Group B streptococcal necrotizing fasciitis and streptococcal toxic shock-like syndrome in adults. Arch Intern Med. 1998. 158:1704-8. [QxMD MEDLINE Link].

15. El Aila NA, Tency I, Claeys G, Saerens B, Cools P, Verstraelen H, et al. Comparison of different sampling techniques and of different culture methods for detection of group B streptococcus carriage in pregnant women. BMC Infect Dis. 2010 Sep 29. 10:285. [QxMD MEDLINE Link].

16. Hicks P, Diaz-Perez MJ. Patient self-collection of group B streptococcal specimens during pregnancy. J Am Board Fam Med. 2009 Mar-Apr. 22 (2):136-40. [QxMD MEDLINE Link].

17. Daniels J, Gray J, Pattison H, Roberts T, Edwards E, Milner P, et al. Rapid testing for group B streptococcus during labour: a test accuracy study with evaluation of acceptability and cost-effectiveness. Health Technol Assess. 2009 Sep. 13(42):1-154, iii-iv. [QxMD MEDLINE Link].

18. Lin FY, Weisman LE, Azimi P, Young AE, Chang K, Cielo M, et al. Assessment of Intrapartum Antibiotic Prophylaxis for the Prevention of Early-onset Group B Streptococcal Disease. Pediatr Infect Dis J. 2011 Sep. 30(9):759-763. [QxMD MEDLINE Link]. [Full Text].

19. Schwope OI, Chen KT, Mehta I, Re M, Rand L. The effect of a chlorhexidine-based surgical lubricant during pelvic examination on the detection of group B Streptococcus. Am J Obstet Gynecol. 2010 Mar. 202(3):276.e1-3. [QxMD MEDLINE Link].

20. Chu YW, Tse C, Tsang GK, So DK, Fung JT, Lo JY. Invasive group B Streptococcus isolates showing reduced susceptibility to penicillin in Hong Kong. J Antimicrob Chemother. 2007 Dec. 60 (6):1407-9. [QxMD MEDLINE Link].

21. Seki T, Kimura K, Reid ME, Miyazaki A, Banno H, Jin W, et al. High isolation rate of MDR group B streptococci with reduced penicillin susceptibility in Japan. J Antimicrob Chemother. 2015 Oct. 70 (10):2725-8. [QxMD MEDLINE Link].

22. Park C, Nichols M, Schrag SJ. Two cases of invasive vancomycin-resistant group B streptococcus infection. N Engl J Med. 2014 Feb 27. 370 (9):885-6. [QxMD MEDLINE Link].

23. Wu HM, Janapatla RP, Ho YR, Hung KH, Wu CW, Yan JJ, et al. Emergence of fluoroquinolone resistance in group B streptococcal isolates in Taiwan. Antimicrob Agents Chemother. 2008 May. 52(5):1888-90. [QxMD MEDLINE Link].

24. Boyer KM, Gadzala CA, Kelly PD, Burd LI, Gotoff SP. Selective intrapartum chemoprophylaxis of neonatal group B streptococcal early-onset disease. II. Predictive value of prenatal cultures. J Infect Dis. 1983 Nov. 148 (5):802-9. [QxMD MEDLINE Link].

25. Yancey MK, Schuchat A, Brown LK, Ventura VL, Markenson GR. The accuracy of late antenatal screening cultures in predicting genital group B streptococcal colonization at delivery. Obstet Gynecol. 1996 Nov. 88 (5):811-5. [QxMD MEDLINE Link].

26. Virranniemi M, Raudaskoski T, Haapsamo M, Kauppila J, Renko M, Peltola J, et al. The effect of screening-to-labor interval on the sensitivity of late-pregnancy culture in the prediction of group B streptococcus colonization at labor: A prospective multicenter cohort study. Acta Obstet Gynecol Scand. 2019 Apr. 98 (4):494-499. [QxMD MEDLINE Link].

27. Turrentine MA, Greisinger AJ, Brown KS, Wehmanen OA, Mouzoon ME. Duration of intrapartum antibiotics for group B streptococcus on the diagnosis of clinical neonatal sepsis. Infect Dis Obstet Gynecol. 2013. 2013:525878. [QxMD MEDLINE Link].

28. Håkansson S, Axemo P, Bremme K, Bryngelsson AL, Wallin MC, Ekström CM, et al. Group B streptococcal carriage in Sweden: a national study on risk factors for mother and infant colonisation. Acta Obstet Gynecol Scand. 2008. 87 (1):50-8. [QxMD MEDLINE Link].

Christian J Woods, MD, FACP, FCCP, FIDSA Associate Program Director for Internal Medicine, Program Director for Pulmonary/Critical Care, Associate MICU Director, Attending in Infectious Diseases/Pulmonary/Critical Care, MedStar Washington Hospital Center

Christian J Woods, MD, FACP, FCCP, FIDSA is a member of the following medical societies: American College of Chest Physicians, American College of Physicians-American Society of Internal Medicine, American Medical Association, American Society for Microbiology, American Thoracic Society, Infectious Diseases Society of America

Disclosure: Nothing to disclose.

Ihab Masri, MD Resident Physician, Department of Internal Medicine, Medstar Washington Hospital Center

Ihab Masri, MD is a member of the following medical societies: American College of Physicians

Disclosure: Nothing to disclose.

Cindy McCartney, MD Resident Physician, Department of Internal Medicine, Medstar Georgetown University/Washington Hospital Center

Cindy McCartney, MD is a member of the following medical societies: American College of Physicians, Infectious Diseases Society of America

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

John L Brusch, MD, FACP Corresponding Faculty Member, Harvard Medical School

John L Brusch, MD, FACP is a member of the following medical societies: American College of Physicians, Infectious Diseases Society of America

Disclosure: Nothing to disclose.

Michael Stuart Bronze, MD David Ross Boyd Professor and Chairman, Department of Medicine, Stewart G Wolf Endowed Chair in Internal Medicine, Department of Medicine, University of Oklahoma Health Science Center; Master of the American College of Physicians; Fellow, Infectious Diseases Society of America; Fellow of the Royal College of Physicians, London

Michael Stuart Bronze, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians, American Medical Association, Association of Professors of Medicine, Infectious Diseases Society of America, Oklahoma State Medical Association, Southern Society for Clinical Investigation

Disclosure: Nothing to disclose.

Pranatharthi Haran Chandrasekar, MBBS, MD Professor, Chief of Infectious Disease, Department of Internal Medicine, Wayne State University School of Medicine

Pranatharthi Haran Chandrasekar, MBBS, MD is a member of the following medical societies: American College of Physicians, American Society for Microbiology, International Immunocompromised Host Society, Infectious Diseases Society of America

Disclosure: Nothing to disclose.

Charles S Levy, MD Associate Professor, Department of Medicine, Section of Infectious Disease, George Washington University School of Medicine

Charles S Levy, MD is a member of the following medical societies: American College of Physicians, Infectious Diseases Society of America, Medical Society of the District of Columbia

Disclosure: Nothing to disclose.

The authors and editors of Medscape Reference gratefully acknowledge the contributions of previous coauthor Mohamad Ossiani, MD, to the development and writing of this article.

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