Trematode Infection Medication

Updated: Nov 23, 2015
  • Author: Subhash Chandra Parija, MD, MBBS, PhD, DSc, FRCPath; Chief Editor: Mark R Wallace, MD, FACP, FIDSA  more...
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Medication Summary

Chemotherapy objectives in trematode infections are to cure the disease, to reduce morbidity, and to prevent transmission of parasitic infection in endemic areas.

Bithionol (Lorothidol, Bitin) is the drug of choice for Fasciola infections; however, it is an investigational drug with distribution limited to physicians with patients who are unable to take praziquantel. Doses of 30-50 mg/kg/d PO for 5-15 days have been used to treat Fasciola infections. Repeat doses may be administered to some patients. Pediatric patients have been administered the same weight-based dosing used in adults. Adverse effects include nausea, vomiting, diarrhea, and abdominal pain.