Treponematosis (Endemic Syphilis, Yaws, and Pinta) Questions & Answers

Updated: Oct 19, 2021
  • Author: Steven M Fine, MD, PhD; Chief Editor: John L Brusch, MD, FACP  more...
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Questions & Answers

Overview

What is treponematosis?

What is the pathophysiology of treponematosis?

What is the US prevalence of treponematosis?

What is the global prevalence of treponematosis?

What is the mortality and morbidity associated with treponematosis?

What are the racial predilections of treponematosis?

What are the sexual predilections of treponematosis?

Which age groups have the highest prevalence of treponematosis?

Presentation

Which clinical history findings are characteristic of treponematosis?

Which physical exam findings are characteristic of endemic syphilis (bejel)?

Which physical exam findings are characteristic of pinta?

Which physical exam findings are characteristic of yaws?

What causes treponematosis?

DDX

What are the differential diagnoses for Treponematosis (Endemic Syphilis, Yaws, and Pinta)?

Workup

How is a diagnosis of treponematosis confirmed?

What is the role of direct microscopy in the workup of treponematosis?

What is the role of nontreponemal tests in the workup of treponematosis?

What is the role of treponemal tests in the workup of treponematosis?

What is the role of rapid point-of-care tests in the workup of treponematosis?

What is the role of imaging studies in the workup of treponematosis?

Which histologic findings are characteristic of treponematosis?

Treatment

How is treponematosis treated?

What are the possible complications of treponematosis?

How is treponematosis prevented?

What is included in the long-term monitoring in patients with treponematosis?

How are treatment failures and reinfection of treponematosis treated?

Medications

What is the role of medications in the treatment of treponematosis?

Which medications in the drug class Antibiotics are used in the treatment of Treponematosis (Endemic Syphilis, Yaws, and Pinta)?