Typhus Treatment & Management

Updated: Oct 10, 2019
  • Author: Jason F Okulicz, MD, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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Medical Care

Antibiotics are the standard of care in the treatment of typhus. Continue antibiotics for 48-72 hours after the fever has resolved. A second course of antibiotic therapy is usually curative in cases of recrudescent typhus.

Other supportive measures may be used as necessary.



Activity is as tolerated.



Avoid exposure to areas known to be endemic for typhus.

Avoid overcrowding.

Insecticides may be helpful in controlling the arthropod vectors that spread typhus.

Reduce the rodent host population.

Wear protective clothing (eg, long-sleeved shirts, long pants) in endemic areas.

Practice good personal hygiene, including frequent bathing and frequent changing of clothes.

Vaccination for typhus is not recommended, and manufacturing of the vaccine has been discontinued in the United States.


Further Outpatient Care

No further outpatient care is usually necessary in uncomplicated cases of typhus.


Further Inpatient Care

Inpatient care may be required for ill patients with typhus who cannot maintain adequate oral hydration/intake or enteral antibiotic therapy.

Patients with complications from typhus may need inpatient care for further diagnosis, evaluation, and management for these disorders (see Complications).

Decisions regarding the need for inpatient care should be assessed on a case-by-case basis.