Ureaplasma Infection Follow-up

Updated: Nov 14, 2022
  • Author: Ken B Waites, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Further Outpatient Care

For serious systemic infections, especially in immunosuppressed hosts, it may be advisable to perform follow-up cultures to determine if infection has been eradicated. If using a molecular-based test, at least 3 weeks should elapse before retesting because dead organisms may still amplify and yield a false positive result.



Because of the frequency with which genital Mycoplasma and Ureaplasma organisms are carried in the lower urogenital tract in persons who are asymptomatic and sexually active, use of barrier protection methods (eg, condoms) is of little benefit because the organisms most often act as opportunistic normal florae. In cases of U urealyticum or M genitalium urogenital infections, sexual partners should also undergo treatment.

Delivery of infants by cesarean delivery has not prevented colonization in the lower respiratory tract because acquisition of the organisms can occur in utero by ascending infection, even through intact fetal membranes.

Although no systematic studies have been performed, the epidemiology of these organisms suggests that persons who are sexually inactive do not usually harbor them and, therefore, cannot be expected to develop clinically significant infections. Abstinence may prevent spread of the organisms among adolescents and adults.