Zygomycosis Treatment & Management

Updated: Aug 12, 2015
  • Author: Jose A Vazquez, MD, FACP, FIDSA; Chief Editor: Mark R Wallace, MD, FACP, FIDSA  more...
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Medical Care

Take aggressive surgical measures to débride affected tissue. Without early and aggressive therapy, mucormycosis is almost always fatal.

Take aggressive measures to control the underlying condition, as follows:

  • Correct hyperglycemia and ketoacidosis to improve outcome.
  • Correct neutropenia with granulocyte colony-stimulating factor (G-CSF) or granulocyte-macrophage colony-stimulating factor (GM-CSF) to improve outcome.

Institute early and appropriate antifungal administration.

If possible, discontinue any immunosuppressant agents, including chemotherapy and steroids.


Surgical Care

The mainstay of treatment for any form of mucormycosis is early and aggressive surgical removal of all infected tissue.

Remove as much devitalized tissue as possible and consider wide surgical debridement, if feasible.

Patients with mucormycosis frequently require numerous surgical procedures to eradicate all infected and necrotic material.



See the list below:

  • Infectious disease specialist

  • Surgeon

  • Otorhinolaryngologist

  • Gastroenterologist

  • Pulmonologist

  • Ophthalmologist

  • Neurosurgeon