Eastern Equine Encephalitis (EEE) Differential Diagnoses

Updated: Aug 21, 2023
  • Author: Mohan Nandalur, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Diagnostic Considerations

The current Centers for Disease Control and Prevention (CDC) guidelines for diagnosis of an arbovirus infection require the presence of an acute febrile illness with encephalitis during a time when viral transmission is likely and at least 1 of the following criteria is met:

  • Greater than 4-fold increase in the viral antibody titer between acute and convalescent sera (often 10 weeks apart)

  • Isolation of the virus from CSF, blood, or tissue

  • Immunoglobulin M (IgM) positive to the organism in the CSF; presumptive positives can be made from the remaining biochemical assays (eg, hemagglutinin inhibition, immunofluorescence, neutralization, complement fixation)

See the following for more information:

Differential Diagnoses