Burkholderia cepacia

1. Lucero CA, Cohen AL, Trevino I, Rupp AH, Harris M, Forkan-Kelly S, et al. Outbreak of Burkholderia cepacia complex among ventilated pediatric patients linked to hospital sinks. Am J Infect Control. 2011 Jun 9. [Medline].

2. Alvarez-Lerma F, Maull E, Terradas R, et al. Moisturizing body milk as a reservoir of Burkholderia cepacia: outbreak of nosocomial infection in a multidisciplinary intensive care unit. Crit Care. 2008. 12(1):R10. [Medline].

3. Abe K, D'Angelo MT, Sunenshine R, et al. Outbreak of Burkholderia cepacia bloodstream infection at an outpatient hematology and oncology practice. Infect Control Hosp Epidemiol. 2007 Nov. 28(11):1311-3. [Medline].

4. Anderson RL, Vess RW, Panlilio AL, et al. Prolonged survival of Pseudomonas cepacia in commercially manufactured povidone-iodine. Appl Environ Microbiol. 1990 Nov. 56(11):3598-600. [Medline].

5. Antibiotic Essentials. Cunha BA. Antibiotic Essentials. 12th ed. Jones & Bartlett, Sudbury, MA: Physicians Press; 2013.

6. Bender JM, Rand TH, Ampofo K, Pavia AT, Schober M, Tebo A, et al. Family clusters of variant X-linked chronic granulomatous disease. Pediatr Infect Dis J. 2009 Jun. 28(6):529-33. [Medline].

7. Berkelman RL, Lewin S, Allen JR, et al. Pseudobacteremia attributed to contamination of povidone-iodine with Pseudomonas cepacia. Ann Intern Med. 1981 Jul. 95(1):32-6. [Medline].

8. Burdge DR, Noble MA, Campbell ME, et al. Xanthomonas maltophilia misidentified as Pseudomonas cepacia in cultures of sputum from patients with cystic fibrosis: a diagnostic pitfall with major clinical implications. Clin Infect Dis. 1995 Feb. 20(2):445-8. [Medline].

9. Clode FE, Metherell LA, Pitt TL. Nosocomial Acquisition of Burkholderia gladioli in patients with cystic fibrosis. Am J Respir Crit Care Med. 1999 Jul. 160(1):374-5. [Medline].

10. Conly JM, Klass L, Larson L, et al. Pseudomonas cepacia colonization and infection in intensive care units. CMAJ. 1986 Feb 15. 134(4):363-6. [Medline].

11. Coutinho CP, Dos Santos SC, Madeira A, Mira NP, Moreira AS, Sá-Correia I. Long-Term colonization of the cystic fibrosis lung by Burkholderia cepacia complex bacteria: epidemiology, clonal variation, and genome-wide expression alterations. Front Cell Infect Microbiol. 2011. 1:12. [Medline]. [Full Text].

12. Craven DE, Moody B, Connolly MG, et al. Pseudobacteremia caused by povidone-iodine solution contaminated with Pseudomonas cepacia. N Engl J Med. 1981 Sep 10. 305(11):621-3. [Medline].

13. Cunha CB, Cunha BA. Pseudoinfections and pseudo-outbreaks. Mayhall CG, ed. Hospital Epidemiology and Infection Control. 4th ed. Lippincott Williams & Wilkins; 2004.

14. De Boeck K, Malfroot A, Van Schil L, et al. Epidemiology of Burkholderia cepacia complex colonisation in cystic fibrosis patients. Eur Respir J. 2004 Jun. 23(6):851-6. [Medline].

15. Duan X, Ling F, Zhou L, et al. Pacemaker generator pocket infection due to Burkholderia cepacia. J Hosp Infect. 2007 Dec. 67(4):392-3. [Medline].

16. Estivariz CF, Bhatti LI, Pati R, Jensen B, Arduino MJ, Jernigan D, et al. An outbreak of Burkholderia cepacia associated with contamination of albuterol and nasal spray. Chest. 2006 Nov. 130(5):1346-53. [Medline].

17. Ewig S, Welte T, Torres A. Is healthcare-associated pneumonia a distinct entity needing specific therapy?. Curr Opin Infect Dis. 2012 Apr. 25(2):166-75. [Medline].

18. Gilardi GL. Infrequently encountered Pseudomonas species causing infection in humans. Ann Intern Med. 1972 Aug. 77(2):211-5. [Medline].

19. Guide SV, Stock F, Gill VJ, Anderson VL, Malech HL, Gallin JI, et al. Reinfection, rather than persistent infection, in patients with chronic granulomatous disease. J Infect Dis. 2003 Mar 1. 187(5):845-53. [Medline].

20. Henderson DK, Baptiste R, Parrillo J, et al. Indolent epidemic of Pseudomonas cepacia bacteremia and pseudobacteremia in an intensive care unit traced to a contaminated blood gas analyzer. Am J Med. 1988 Jan. 84(1):75-81. [Medline].

21. Hutchinson J, Runge W, Mulvey M, et al. Burkholderia cepacia infections associated with intrinsically contaminated ultrasound gel: the role of microbial degradation of parabens. Infect Control Hosp Epidemiol. 2004 Apr. 25(4):291-6. [Medline].

22. Jones AM, Stanbridge TN, Isalska BJ, et al. Burkholderia gladioli: recurrent abscesses in a patient with cystic fibrosis. J Infect. 2001 Jan. 42(1):69-71. [Medline].

23. Lambiase A, Raia V, Stefani S, et al. Burkholderia cepacia complex infection in a cohort of Italian patients with cystic fibrosis. J Microbiol. 2007 Jun. 45(3):275-9. [Medline].

24. Lee CS, Lee HB, Cho YG, et al. Hospital-acquired Burkholderia cepacia infection related to contaminated benzalkonium chloride. J Hosp Infect. 2008 Mar. 68(3):280-2. [Medline].

25. Leitão JH, Sousa SA, Cunha MV, Salgado MJ, Melo-Cristino J, Barreto MC, et al. Variation of the antimicrobial susceptibility profiles of Burkholderia cepacia complex clonal isolates obtained from chronically infected cystic fibrosis patients: a five-year survey in the major Portuguese treatment center. Eur J Clin Microbiol Infect Dis. 2008 Nov. 27(11):1101-11. [Medline].

26. Liao CH, Chang HT, Lai CC, Huang YT, Hsu MS, Liu CY, et al. Clinical characteristics and outcomes of patients with Burkholderia cepacia bacteremia in an intensive care unit. Diagn Microbiol Infect Dis. 2011 Jun. 70(2):260-6. [Medline].

27. Lipuma JJ, Marks-Austin KA, Holsclaw DS, et al. Inapparent transmission of Pseudomonas (Burkholderia) cepacia among patients with cystic fibrosis. Pediatr Infect Dis J. 1994 Aug. 13(8):716-9. [Medline].

28. Lopez A, Amaro R, Polverino E. Does health care associated pneumonia really exist?. Eur J Intern Med. 2012 Jul. 23(5):407-11. [Medline].

29. Lucero CA, Cohen AL, Trevino I, Rupp AH, Harris M, Forkan-Kelly S, et al. Outbreak of Burkholderia cepacia complex among ventilated pediatric patients linked to hospital sinks. Am J Infect Control. 2011 Nov. 39(9):775-8. [Medline].

30. Mahenthiralingam E, Vandamme P. Taxonomy and pathogenesis of the Burkholderia cepacia complex. Chron Respir Dis. 2005. 2(4):209-17. [Medline].

31. Martin M, Christiansen B, Caspari G, Hogardt M, von Thomsen AJ, Ott E, et al. Hospital-wide outbreak of Burkholderia contaminans caused by prefabricated moist washcloths. J Hosp Infect. 2011 Mar. 77(3):267-70. [Medline].

32. Martin M, Winterfeld I, Kramme E, Ewert I, Sedemund-Adib B, Mattner F. [Outbreak of Burkholderia cepacia complex caused by contaminated alcohol-free mouthwash]. Anaesthesist. 2012 Jan. 61(1):25-9. [Medline].

33. Martone WJ, Osterman CA, Fisher KA, et al. Pseudomonas cepacia: implications and control of epidemic nosocomial colonization. Rev Infect Dis. 1981 Jul-Aug. 3(4):708-15. [Medline].

34. McMenamin JD, Zaccone TM, Coenye T, et al. Misidentification of Burkholderia cepacia in US cystic fibrosis treatment centers: an analysis of 1,051 recent sputum isolates. Chest. 2000 Jun. 117(6):1661-5. [Medline].

35. Nasser RM, Rahi AC, Haddad MF, et al. Outbreak of Burkholderia cepacia bacteremia traced to contaminated hospital water used for dilution of an alcohol skin antiseptic. Infect Control Hosp Epidemiol. 2004 Mar. 25(3):231-9. [Medline].

36. Pallent LJ, Hugo WB, Grant DJ, et al. Pseudomonas cepacia as contaminant and infective agent. J Hosp Infect. 1983 Mar. 4(1):9-13. [Medline].

37. Panlilio AL, Beck-Sague CM, Siegel JD, et al. Infections and pseudoinfections due to povidone-iodine solution contaminated with Pseudomonas cepacia. Clin Infect Dis. 1992 May. 14(5):1078-83. [Medline].

38. Rosenstein BJ, Hall DE. Pneumonia and septicemia due to Pseudomonas cepacia in a patient with cystic fibrosis. Johns Hopkins Med J. 1980 Nov. 147(5):188-9. [Medline].

39. Rutala WA, Weber DJ, Thomann CA, et al. An outbreak of Pseudomonas cepacia bacteremia associated with a contaminated intra-aortic balloon pump. J Thorac Cardiovasc Surg. 1988 Jul. 96(1):157-61. [Medline].

40. Schaffner W, Reisig G, Verrall RA. Outbreak of Pseudomonas cepacia infection due to contaminated anaesthetics. Lancet. 1973 May 12. 1(7811):1050-1. [Medline].

41. Sobel JD, Hashman N, Reinherz G, Merzbach D. Nosocomial Pseudomonas cepacia infection associated with chlorhexidine contamination. Am J Med. 1982 Aug. 73(2):183-6. [Medline].

42. Speller DC, Stephens ME, Viant AC. Hospital infection by Pseudomonas cepacia. Lancet. 1971 Apr 17. 1(7703):798-9. [Medline].

43. St Denis M, Ramotar K, Vandemheen K, et al. Infection with Burkholderia cepacia complex bacteria and pulmonary exacerbations of cystic fibrosis. Chest. 2007 Apr. 131(4):1188-96. [Medline].

44. Steere AC, Tenney JH, Mackel DC, et al. Pseudomonas species bacteremia caused by contaminated normal human serum albumin. J Infect Dis. 1977 May. 135(5):729-35. [Medline].

45. Tablan OC, Martone WJ, Jarvis WR. The epidemiology of Pseudomonas cepacia in patients with cystic fibrosis. Eur J Epidemiol. 1987 Dec. 3(4):336-42. [Medline].

46. van den Berg JM, van Koppen E, Ahlin A, Belohradsky BH, Bernatowska E, Corbeel L, et al. Chronic granulomatous disease: the European experience. PLoS One. 2009. 4(4):e5234. [Medline]. [Full Text].

47. Weems JJ. Nosocomial outbreak of Pseudomonas cepacia associated with contamination of reusable electronic ventilator temperature probes. Infect Control Hosp Epidemiol. 1993 Oct. 14(10):583-6. [Medline].

48. Wilson JA, Viggars S, Parsons A. Pseudomonas cepacia pseudobacteraemia associated with a contaminated blood gas analyzer. J Hosp Infect. 1987 Nov. 10(3):314-5. [Medline].

49. Yamagishi Y, Fujita J, Takigawa K, et al. Clinical features of Pseudomonas cepacia pneumonia in an epidemic among immunocompromised patients. Chest. 1993 Jun. 103(6):1706-9. [Medline].

50. Zainal Abidin I, Syed Tamin S, Huat Tan L, et al. Pacemaker infection secondary to burkholderia pseudomallei. Pacing Clin Electrophysiol. 2007 Nov. 30(11):1420-2. [Medline].

51. Ángeles-Garay U, Zacate-Palacios Y, López-Herrera JR, Hernández-Sánchez EA, Silva-Sánchez J, Ascencio-Montiel Ide J. [Hospital outbreak of urinary tract infections by lubricant gel contaminated with Burkholderia cepacia]. Rev Med Inst Mex Seguro Soc. 2012 Nov-Dec. 50(6):615-22. [Medline].

Burke A Cunha, MD Professor of Medicine, State University of New York School of Medicine at Stony Brook; Chief, Infectious Disease Division, Winthrop-University Hospital

Burke A Cunha, MD is a member of the following medical societies: American College of Chest Physicians, American College of Physicians, Infectious Diseases Society of America

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Richard B Brown, MD, FACP Chief, Division of Infectious Diseases, Baystate Medical Center; Professor, Department of Internal Medicine, Tufts University School of Medicine

Richard B Brown, MD, FACP is a member of the following medical societies: Alpha Omega Alpha, American College of Chest Physicians, American College of Physicians, American Medical Association, American Society for Microbiology, Infectious Diseases Society of America, Massachusetts Medical Society

Disclosure: Nothing to disclose.

Michael Stuart Bronze, MD David Ross Boyd Professor and Chairman, Department of Medicine, Stewart G Wolf Endowed Chair in Internal Medicine, Department of Medicine, University of Oklahoma Health Science Center; Master of the American College of Physicians; Fellow, Infectious Diseases Society of America

Michael Stuart Bronze, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians, American Medical Association, Association of Professors of Medicine, Infectious Diseases Society of America, Oklahoma State Medical Association, Southern Society for Clinical Investigation

Disclosure: Nothing to disclose.

Charles S Levy, MD Associate Professor, Department of Medicine, Section of Infectious Disease, George Washington University School of Medicine

Charles S Levy, MD is a member of the following medical societies: American College of Physicians, Infectious Diseases Society of America, Medical Society of the District of Columbia

Disclosure: Nothing to disclose.

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