Human Metapneumovirus Differential Diagnoses

Updated: Jan 18, 2017
  • Author: Aliyah Baluch, MD, MSc, FACP; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Diagnostic Considerations

Coinfection with human metapneumovirus (hMPV) and other viral respiratory pathogens has been documented in several studies, with the clinical significance in these situations unclear. [37, 38, 39, 40] RSV and hMPV coinfection was found in 70% of children with RSV infection who required intensive care in Liverpool, United Kingdom. [37] In addition, Semple et al showed that the rate of intensive care admissions and mechanical ventilation in patients coinfected with RSV and hMPV was greater than in infection with either pathogen alone. [39] However, other studies have not shown that coinfection plays a significant role in disease severity. [38, 41] Thus, further research is needed to definitively elucidate the clinical impact of coinfection.

Differential Diagnoses