Acute Tubular Necrosis Questions & Answers

Updated: Mar 15, 2021
  • Author: Sangeeta Mutnuri, MBBS; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Questions & Answers

Overview

What is acute tubular necrosis (ATN)?

What are the sequences of disease progression in acute tubular necrosis (ATN)?

What causes tubule cell damage and cell death in acute tubular necrosis (ATN)?

How is the cause of acute tubular necrosis (ATN) identified?

How is acute tubular necrosis (ATN) managed?

What is the pathophysiology of acute tubular necrosis (ATN)?

What is the pathophysiology of the initiation phase of acute tubular necrosis (ATN)?

What is the pathophysiology of the maintenance phase of acute tubular necrosis (ATN)?

What is the pathophysiology of the recovery phase of acute tubular necrosis (ATN)?

What is the pathophysiology of normotensive ischemic acute tubular necrosis (ATN)?

What is the pathophysiology of endotoxemia (sepsis)-related acute tubular necrosis (ATN)?

What causes ischemic acute tubular necrosis (ATN)?

What causes nephrotoxic acute tubular necrosis (ATN)?

What are the risk factors for aminoglycoside caused acute tubular necrosis (ATN)?

What are the risk factors for amphotericin B nephrotoxicity caused acute tubular necrosis (ATN)?

Which exogenous nephrotoxins can cause acute tubular necrosis (ATN)?

Which endogenous nephrotoxins cause acute tubular necrosis (ATN)?

What is the in-hospital survival rate among patients with acute tubular necrosis (ATN)?

What is the mortality rate of acute tubular necrosis (ATN)?

What is the prognosis of oliguric acute tubular necrosis (ATN)?

What is the prevalence of end-stage renal disease (ESRD) in acute tubular necrosis (ATN)?

What is the prevalence of acute tubular necrosis (ATN)?

Presentation

Which clinical history is characteristic of acute tubular necrosis (ATN)?

What are the physical findings characteristic of acute tubular necrosis (ATN)?

DDX

What are the differential diagnoses for Acute Tubular Necrosis?

Workup

Which tests should be performed in the workup of acute tubular necrosis (ATN)?

What is the role of lab testing in the workup of acute tubular necrosis (ATN)?

Which nephrotoxicity findings suggest a specific medication causing acute tubular necrosis (ATN)?

How is the degree of acute kidney injury (AKI) determined in acute tubular necrosis (ATN)?

What is the role of urinalysis in the workup of acute tubular necrosis (ATN)?

What is the role of ultrasonography in the workup of acute tubular necrosis (ATN)?

What is the role of abdominal radiography in the workup of acute tubular necrosis (ATN)?

What is the role of CT scanning in the workup of acute tubular necrosis (ATN)?

What is the role of MRI in the workup of acute tubular necrosis (ATN)?

What is the role of renal biopsy in the workup of acute tubular necrosis (ATN)?

What is the role of biomarkers in the workup of acute tubular necrosis (ATN)?

What is the role of furosemide stress testing in the workup of acute tubular necrosis (ATN)?

Treatment

How are patients at risk for acute tubular necrosis (ATN) proactively managed?

Which group of patients are likely to develop acute tubular necrosis (ATN)?

What are the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines for managing acute tubular necrosis (ATN)?

What is the role of diuretics in the treatment of acute tubular necrosis (ATN)?

When is dialysis indicated in the treatment of acute tubular necrosis (ATN)?

What can the options for renal replacement therapy in acute tubular necrosis (ATN)?

What is the treatment of choice for nephrotoxic acute tubular necrosis (ATN)?

What are possible complications of acute tubular necrosis (ATN)?

What are complications of altered fluid and electrolyte balance in acute tubular necrosis (ATN)?

What are the signs and symptoms of uremia in acute tubular necrosis (ATN)?

What is the prevalence of infections in acute tubular necrosis (ATN)?

What are the causes of anemia in acute tubular necrosis (ATN)?

What are KDIGO dietary guidelines for acute tubular necrosis (ATN)?

What is the role of N-acetylcysteine (NAC) in the prevention of acute tubular necrosis (ATN)?

How is nephrotoxic acute tubular necrosis (ATN) prevented?

How is contrast-induced nephropathy (CIN) in acute tubular necrosis (ATN) prevented?

What is the efficacy of isotonic sodium bicarbonate for the prevention of contrast-induced nephropathy (CIN) in acute tubular necrosis (ATN)?

What is the role of nonionic contrast media in the prevention of acute tubular necrosis (ATN)?

What should be avoided to prevent contrast-induced nephropathy (CIN) in acute tubular necrosis (ATN)?

Which interventions to decrease the risk of contrast-induced nephropathy (CIN) in acute tubular necrosis (ATN) lack evidence of efficacy?

How is rhabdomyolysis prevented in acute tubular necrosis (ATN)?

What is included in long-term monitoring of acute tubular necrosis (ATN)?

Medications

What is the role of medications in the management of acute tubular necrosis (ATN)?