Uremic Encephalopathy Clinical Presentation

Updated: Mar 13, 2020
  • Author: James W Lohr, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Presentation

History

Early symptoms of uremic encephalopathy include the following:

  • Anorexia
  • Nausea
  • Restlessness
  • Drowsiness
  • Diminished ability to concentrate
  • Slowed cognitive functions

More severe signs and symptoms of uremic encephalopathy include the following:

  • Vomiting
  • Emotional volatility
  • Decreased cognitive function
  • Disorientation
  • Confusion
  • Bizarre behavior
  • Stupor, coma
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Physical

Physical examination findings may include the following:

  • Altered mental status (confusion)
  • Cranial nerve signs (nystagmus)
  • Papilledema
  • Hyperreflexia, clonus, asterixis
  • Altered gait
  • Stupor
  • Coma (occurs only if uremia remains untreated and progresses)
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