Kawasaki Y. Mechanism of onset and exacerbation of chronic glomerulonephritis and its treatment. Pediatr Int. 2011 Dec. 53(6):795-806. [QxMD MEDLINE Link].
Sethi S, Nester CM, Smith RJ. Membranoproliferative glomerulonephritis and C3 glomerulopathy: resolving the confusion. Kidney Int. 2011 Dec 7. [QxMD MEDLINE Link].
Goto M, Wakai K, Kawamura T, et al. A scoring system to predict renal outcome in IgA nephropathy: a nationwide 10-year prospective cohort study. Nephrol Dial Transplant. 2009 Oct. 24(10):3068-74. [QxMD MEDLINE Link]. [Full Text].
Schöll U, Wastl U, Risler T, Braun N, Grabensee B, Heering P, et al. The "point of no return" and the rate of progression in the natural history of IgA nephritis. Clin Nephrol. 1999 Nov. 52(5):285-92. [QxMD MEDLINE Link].
Fernandes das Neves M, Irlapati RV, Isenberg D. Assessment of long-term remission in lupus nephritis patients: a retrospective analysis over 30 years. Rheumatology (Oxford). 2015 Aug. 54 (8):1403-7. [QxMD MEDLINE Link].
Wang Y, Huang X, Cai J, Xie L, Wang W, Tang S, et al. Clinicopathologic Characteristics and Outcomes of Lupus Nephritis With Antineutrophil Cytoplasmic Antibody: A Retrospective Study. Medicine (Baltimore). 2016 Jan. 95 (4):e2580. [QxMD MEDLINE Link].
Nakai S, Wada A, et al. An overview of regular dialysis treatment in Japan (as of 31 December 2004). Ther Apher Dial. 2006. 10:476-97. [QxMD MEDLINE Link]. [Full Text].
Research Group on Progressive Chronic Renal Disease. Nationwide and long-term survey of primary glomerulonephritis in Japan as observed in 1,850 biopsied cases. Nephron. 1999. 82(3):205-13. [QxMD MEDLINE Link].
Blowey DL, Warady BA. Outcome of infants born to women with chronic kidney disease. Adv Chronic Kidney Dis. 2007. 14:199-205. [QxMD MEDLINE Link].
Imbasciati E, Gregorini G, Cabiddu G, Gammaro L, Ambroso G, Del Giudice A, et al. Pregnancy in CKD stages 3 to 5: fetal and maternal outcomes. Am J Kidney Dis. 2007. 49:753-62. [QxMD MEDLINE Link].
Idasiak-Piechocka I, Oko A, Pawliczak E, Kaczmarek E, Czekalski S. Urinary excretion of soluble tumour necrosis factor receptor 1 as a marker of increased risk of progressive kidney function deterioration in patients with primary chronic glomerulonephritis. Nephrol Dial Transplant. 2010 Dec. 25(12):3948-56. [QxMD MEDLINE Link].
Hindricks J, Ebert T, Bachmann A, Kralisch S, Lössner U, Kratzsch J, et al. Serum levels of fibroblast growth factor-21 are increased in chronic and acute renal dysfunction. Clin Endocrinol (Oxf). 2014 Jun. 80 (6):918-24. [QxMD MEDLINE Link].
Abou-Mrad RM, Abu-Alfa AK, Ziyadeh FN. Effects of weight reduction regimens and bariatric surgery on chronic kidney disease in obese patients. Am J Physiol Renal Physiol. 2013 Sep 1. 305(5):F613-7. [QxMD MEDLINE Link].
Wolf G. Antiproteinuric response to dual blockade of the renin-angiotensin system in primary glomerulonephritis. Nat Clin Pract Nephrol. 2008 Sep. 4(9):474-5. [QxMD MEDLINE Link].
Tsuruoka S, Kai H, Usui J, Morito N, Saito C, Yoh K, et al. Effects of irbesartan on inflammatory cytokine concentrations in patients with chronic glomerulonephritis. Intern Med. 2013. 52(3):303-8. [QxMD MEDLINE Link].
Wolf G, Ritz E. Combination therapy with ACE inhibitors and angiotensin II receptor blockers to halt progression of chronic renal disease: pathophysiology and indications. Kidney Int. 2005. 67:799-812. [QxMD MEDLINE Link].
Yusuf S, Teo KK, Pogue J, et al. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med. 2008 Apr 10. 358(15):1547-59. [QxMD MEDLINE Link].
Omae K, Ogawa T, Nitta K. Influence of T-calcium channel blocker treatment on deterioration of renal function in chronic kidney disease. Heart Vessels. 2009 Jul. 24(4):301-7. [QxMD MEDLINE Link].
Cho ME, Smith DC, Branton MH, et al. Pirfenidone slows renal function decline in patients with focal segmental glomerulosclerosis. Clin J Am Soc Nephrol. 2007 Sep. 2(5):906-13. [QxMD MEDLINE Link].
de Brito-Ashurst I, Varagunam M, Raftery MJ, Yaqoob MM. Bicarbonate supplementation slows progression of CKD and improves nutritional status. J Am Soc Nephrol. 2009 Sep. 20(9):2075-84. [QxMD MEDLINE Link]. [Full Text].
Mahajan A, Simoni J, Sheather SJ, Broglio KR, Rajab MH, Wesson DE. Daily oral sodium bicarbonate preserves glomerular filtration rate by slowing its decline in early hypertensive nephropathy. Kidney Int. 2010 Aug. 78(3):303-9. [QxMD MEDLINE Link].
Goraya N, Simoni J, Jo CH, Wesson DE. A comparison of treating metabolic acidosis in CKD stage 4 hypertensive kidney disease with fruits and vegetables or sodium bicarbonate. Clin J Am Soc Nephrol. 2013 Mar. 8(3):371-81. [QxMD MEDLINE Link]. [Full Text].
Parving HH, Persson F, Lewis JB, Lewis EJ, Hollenberg NK. Aliskiren combined with losartan in type 2 diabetes and nephropathy. N Engl J Med. 2008 Jun 5. 358(23):2433-46. [QxMD MEDLINE Link].
Naguib MT. Kidney disease in the obese patient. South Med J. 2014 Aug. 107(8):481-5. [QxMD MEDLINE Link].
Cameron JS. The Long-Term Outcome of Glomerular Diseases. Schrier RW, Gottschalk CW, ed. Diseases of the Kidney. 6th ed. Little, Brown & Company: Boston, Mass; 1997. 1919.
[Guideline] K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002 Feb. 39(2 Suppl 1):S1-266. [QxMD MEDLINE Link].
Murray SL, Dorman A, Benson KA, Connaughton DM, Stapleton CP, Fennelly NK, et al. Utility of Genomic Testing after Renal Biopsy. Am J Nephrol. 2020. 51 (1):43-53. [QxMD MEDLINE Link].
Rule AD, Larson TS, Bergstralh EJ, Slezak JM, Jacobsen SJ, Cosio FG. Using serum creatinine to estimate glomerular filtration rate: accuracy in good health and in chronic kidney disease. Ann Intern Med. 2004 Dec 21. 141 (12):929-37. [QxMD MEDLINE Link].
Hsu CY, Yang W, Parikh RV, Anderson AH, Chen TK, Cohen DL, et al. Race, Genetic Ancestry, and Estimating Kidney Function in CKD. N Engl J Med. 2021 Nov 04. 385 (19):1750-1760. [QxMD MEDLINE Link]. [Full Text].
Andrew S. Levey, Silvia M. Titan, Neil R. Powe, Josef Coresh and Lesley A. Inker. Kidney Disease, Race, and GFR Estimation. CJASN. Aug 2020. 15(8):1203-1212. [QxMD MEDLINE Link]. [Full Text].
L.A. Inker, N.D. Eneanya, J. Coresh, H. Tighiouart, D. Wang, Y. Sang, et al. New Creatinine- and Cystatin C–Based Equations to Estimate GFR without Race. N Engl J Med. 2021 Nov 4. 385(18):1737-1749. [QxMD MEDLINE Link]. [Full Text].
van der Aart-van der Beek AB, de Boer RA, Heerspink HJL. Kidney and heart failure outcomes associated with SGLT2 inhibitor use. Nat Rev Nephrol. 2022 May. 18(5):294-306. [QxMD MEDLINE Link]. [Full Text].
DeFronzo RA, Bakris GL. Modifying chronic kidney disease progression with the mineralocorticoid receptor antagonist finerenone in patients with type 2 diabetes. Diabetes Obes Metab. 2022 July 24. Vol 24 Issue 7:1197-1205. [QxMD MEDLINE Link]. [Full Text].
de Zeeuw D, et al; BEACON Trial Investigators. Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease. N Engl J Med. 2013 Dec 26. 369 (26):2492-503. [QxMD MEDLINE Link]. [Full Text].
Nangaku M, Takama H, Ichikawa T, Mukai K, Kojima M, Suzuki Y, et al. Randomized, double-blind, placebo-controlled phase 3 study of bardoxolone methyl in patients with diabetic kidney disease: Design and baseline characteristics of AYAME study. Nephrol Dial Transplant. 2022 Aug 24. [QxMD MEDLINE Link]. [Full Text].

Media Gallery

Renal corpuscle.
Photomicrograph of a kidney biopsy from a patient with crescentic glomerulonephritis showing prominent fibrocellular crescent formation and moderate mesangial proliferation in a glomerulus. Hematoxylin and eosin stain. Image courtesy of Wikipedia.
Membranoproliferative glomerulonephritis (MPGN) type I. Glomerulus with lobular accentuation from increased mesangial cellularity. A segmental increase occurs in the mesangial matrix, and the peripheral capillary walls are thickened (hematoxylin and eosin stained section; original magnification × 250). Courtesy of John A. Minielly, MD.

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Author

Moro O Salifu, MD, MPH, MBA, MACP Associate Professor, Department of Internal Medicine, Chief, Division of Nephrology, Director of Nephrology Fellowship Program and Transplant Nephrology, State University of New York Downstate Medical Center

Moro O Salifu, MD, MPH, MBA, MACP is a member of the following medical societies: American College of Physicians-American Society of Internal Medicine, American Medical Association, American Society for Artificial Internal Organs, American Society of Diagnostic and Interventional Nephrology, American Society of Nephrology, American Society of Transplantation, National Kidney Foundation

Disclosure: Nothing to disclose.

Coauthor(s)

Subodh J Saggi, MD, MPH, FACP, FASN Professor of Medicine (with Tenure), Fellowship Program Director (Nephrology and Nephrology-Critical Care), Medical Director, Pancreas Transplant Program, State University of New York Downstate College of Medicine

Subodh J Saggi, MD, MPH, FACP, FASN is a member of the following medical societies: American College of Physicians, American Society of Nephrology, American Society of Transplantation

Disclosure: Nothing to disclose.

Chief Editor

Vecihi Batuman, MD, FASN Huberwald Professor of Medicine, Section of Nephrology-Hypertension, Interim Chair, Deming Department of Medicine, Tulane University School of Medicine

Vecihi Batuman, MD, FASN is a member of the following medical societies: American College of Physicians, American Society of Hypertension, American Society of Nephrology, International Society of Nephrology, Southern Society for Clinical Investigation

Disclosure: Nothing to disclose.

Additional Contributors

Barbara G Delano, MD, MPH, FACP Professor and Chair, Department of Community Health Sciences, School of Public Health, State University of New York Downstate

Barbara G Delano, MD, MPH, FACP is a member of the following medical societies: American Society of Nephrology, International Society of Nephrology, National Kidney Foundation, Sigma Xi, The Scientific Research Honor Society

Disclosure: Nothing to disclose.

Acknowledgements

George R Aronoff, MD Director, Professor, Departments of Internal Medicine and Pharmacology, Section of Nephrology, Kidney Disease Program, University of Louisville School of Medicine

George R Aronoff, MD is a member of the following medical societies: American Federation for Medical Research, American Society of Nephrology, Kentucky Medical Association, and National Kidney Foundation

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Salary Employment

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