Diffuse Proliferative Glomerulonephritis Differential Diagnoses

Updated: Mar 09, 2023
  • Author: Moro O Salifu, MD, MPH, MBA, MACP; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Diagnostic Considerations

Goodpasture syndrome is not the only cause of the pulmonary-renal syndrome (ie, kidney failure, lung hemorrhage). Other important causes of pulmonary-renal symptoms include the following:

  • Severe cardiac failure complicated by pulmonary edema (often manifesting as blood-tinged sputum) and prerenal azotemia
  • Kidney failure from any cause complicated by hypervolemia and pulmonary edema
  • Immune complex–mediated vasculitides, including systemic lupus erythematosus (SLE), Henoch-Schönlein purpura, and cryoglobulinemia
  • Pauci-immune vasculitides, including granulomatosis with polyangiitis and microscopic polyangiitis
  • Infections, such as Legionnaire disease
  • Renal vein thrombosis with pulmonary embolism

Differential Diagnoses