IgA Nephropathy Questions & Answers

Updated: Feb 15, 2018
  • Author: Sohail Abdul Salim, MD, FASN, FACP; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Questions & Answers

Overview

What is immunoglobulin A (IgA) nephropathy?

Where can additional information on immunoglobulin A (IgA) nephropathy be found?

What is the pathophysiology of immunoglobulin A (IgA) nephropathy?

What is the prevalence of immunoglobulin A (IgA) nephropathy in the US?

What is the global prevalence of immunoglobulin A (IgA) nephropathy?

What is the mortality and morbidity in immunoglobulin A (IgA) nephropathy?

Which patient groups are at highest risk for immunoglobulin A (IgA) nephropathy?

What is the prognosis of immunoglobulin A (IgA) nephropathy?

What is the MEST-C score for immunoglobulin A (IgA) nephropathy?

How is the MEST-C score used for prognostication of immunoglobulin A (IgA) nephropathy?

Which factors are predictors of poor renal outcomes for immunoglobulin A (IgA) nephropathy?

Presentation

Which medical history is characteristic of immunoglobulin A (IgA) nephropathy?

What are the signs and symptoms of episodic gross hematuria in immunoglobulin A (IgA) nephropathy?

Which physical findings are characteristic of immunoglobulin A (IgA) nephropathy?

What causes immunoglobulin A (IgA) nephropathy?

What is the role of liver disease in the etiology of immunoglobulin A (IgA) nephropathy?

What is the role of gluten enteropathy (celiac disease) in the etiology of immunoglobulin A (IgA) nephropathy?

What is the role of HIV infection in the etiology of immunoglobulin A (IgA) nephropathy?

What is the role of genetics in the etiology of immunoglobulin A (IgA) nephropathy?

DDX

What are the differential diagnoses for IgA Nephropathy?

Workup

What is the prevalence of acute kidney injuries in immunoglobulin A (IgA) nephropathy?

How is a diagnosis of immunoglobulin A (IgA) nephropathy confirmed?

How is renal function assessed in the diagnosis of immunoglobulin A (IgA) nephropathy?

What is the significance of proteinuria in the evaluation of immunoglobulin A (IgA) nephropathy?

What is the role of electron microscopy in the diagnosis of immunoglobulin A (IgA) nephropathy?

What is the role of immunofluorescence in the diagnosis of immunoglobulin A (IgA) nephropathy?

What is the role of light microscopy in the diagnosis of immunoglobulin A (IgA) nephropathy?

Treatment

What are the treatment options for immunoglobulin A (IgA) nephropathy?

How is glomerulonephritis managed in immunoglobulin A (IgA) nephropathy?

What is the role of renin-angiotensin blockade in the treatment of immunoglobulin A (IgA) nephropathy?

What is the role of corticosteroids and other immunosuppressive agents in the treatment of immunoglobulin A (IgA) nephropathy?

What is the efficacy of corticosteroids in the treatment of immunoglobulin A (IgA) nephropathy?

Which treatment for immunoglobulin A (IgA) nephropathy is recommended against by KDIGO guidelines?

What is the efficacy of supportive care for the treatment of immunoglobulin A (IgA) Nephropathy?

What is the efficacy of immunosuppressive therapy for immunoglobulin A (IgA) nephropathy?

What is the role of fish oil (omega-3 fatty acids) in the treatment of immunoglobulin A (IgA) neuropathy?

What is the role of calcitriol in the treatment of immunoglobulin A (IgA) neuropathy?

What is the role of rituximab in the treatment of immunoglobulin A (IgA) neuropathy?

Which dietary modifications are used in the treatment of immunoglobulin A (IgA) neuropathy?

What is the role of tonsillectomy in the treatment of immunoglobulin A (IgA) neuropathy?

What is the role of renal transplantation in the treatment of immunoglobulin A (IgA) neuropathy?

Guidelines

What are the MHLW/JSN treatment guidelines for immunoglobulin A (IgA) neuropathy in patients with chronic kidney disease?

What are the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines for evaluation of immunoglobulin A (IgA) neuropathy?

What are the Kidney Disease: Improving Global Outcomes (KDIGO) treatment guidelines for immunoglobulin A (IgA) neuropathy?

Which treatments for immunoglobulin A (IgA) neuropathy do the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend against?

What is the bases for treatment selection for immunoglobulin A (IgA) neuropathy according to MHLW/JSN guidelines?

Which treatments should be considered for immunoglobulin A (IgA) neuropathy according to Ministry of Health Labour and Welfare (MHLW) and Japanese Society of Nephrology (JSN) guidelines?

What are the MHLW/JSN guidelines grade C1 recommendations for treatment of immunoglobulin A (IgA) neuropathy?

Medications

What is the role of medications in the treatment of immunoglobulin A (IgA) neuropathy?

Which medications in the drug class Immunosuppressive agents are used in the treatment of IgA Nephropathy?

Which medications in the drug class Omega-3 polyunsaturated fatty acids are used in the treatment of IgA Nephropathy?

Which medications in the drug class Corticosteroids are used in the treatment of IgA Nephropathy?

Which medications in the drug class Angiotensin II receptor antagonists are used in the treatment of IgA Nephropathy?

Which medications in the drug class Angiotensin-converting enzyme inhibitors are used in the treatment of IgA Nephropathy?