Overview
What is poststreptococcal glomerulonephritis?
What is the pathophysiology of poststreptococcal glomerulonephritis?
What causes poststreptococcal glomerulonephritis?
What is the prevalence of poststreptococcal glomerulonephritis in the US?
What is the global prevalence of poststreptococcal glomerulonephritis?
What are the racial predilections of poststreptococcal glomerulonephritis?
Which patient groups have the highest prevalence of poststreptococcal glomerulonephritis?
What is the prognosis of poststreptococcal glomerulonephritis?
What are the possible complications of acute poststreptococcal glomerulonephritis?
What are the possible complications of chronic poststreptococcal glomerulonephritis?
What is included in patient education about poststreptococcal glomerulonephritis?
Presentation
Which clinical history findings are characteristic of poststreptococcal glomerulonephritis?
What are the signs and symptoms of complicated acute poststreptococcal glomerulonephritis (APSGN)?
Which physical findings are characteristic of poststreptococcal glomerulonephritis?
What are the signs and symptoms of edema in poststreptococcal glomerulonephritis?
Which physical findings are characteristic of hypertension in poststreptococcal glomerulonephritis?
What causes hypertension in poststreptococcal glomerulonephritis?
How prevalent is hypertensive encephalopathy in poststreptococcal glomerulonephritis?
What are the signs and symptoms of oliguria in poststreptococcal glomerulonephritis?
What are the possible cardiovascular findings in poststreptococcal glomerulonephritis?
What is the prevalence of pulmonary hemorrhage in poststreptococcal glomerulonephritis?
DDX
Which conditions are included in the differential diagnoses of poststreptococcal glomerulonephritis?
What are the differential diagnoses for Poststreptococcal Glomerulonephritis?
Workup
What is the role of lab tests in the workup of poststreptococcal glomerulonephritis?
What is the role of kidney function studies in the workup of poststreptococcal glomerulonephritis?
Which serologic findings are characteristic of poststreptococcal glomerulonephritis?
Which urinalysis findings are characteristic of poststreptococcal glomerulonephritis?
What is the role of NT-proBNP measurement in the workup of poststreptococcal glomerulonephritis?
Which imaging studies are characteristic of poststreptococcal glomerulonephritis?
Which pathologic findings are characteristic of poststreptococcal glomerulonephritis?
Which light microscopy findings are characteristic of poststreptococcal glomerulonephritis?
Which immunofluorescence findings are characteristic of poststreptococcal glomerulonephritis?
Which electron microscopy findings are characteristic of poststreptococcal glomerulonephritis?
When is renal biopsy indicated in the workup of acute poststreptococcal glomerulonephritis (APSGN)?
Treatment
How is poststreptococcal glomerulonephritis treatment?
What is the role of kidney biopsy in the treatment of poststreptococcal glomerulonephritis?
What is the role of throat cultures in the treatment of poststreptococcal glomerulonephritis?
How are skin infections treated in poststreptococcal glomerulonephritis?
When is empirical prophylactic treatment for poststreptococcal glomerulonephritis indicated?
Which specialist consultations are beneficial to patients with poststreptococcal glomerulonephritis?
How is poststreptococcal glomerulonephritis prevented?
What is included in the long-term monitoring of poststreptococcal glomerulonephritis?
Medications
What is the role of medications in the treatment of poststreptococcal glomerulonephritis?
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Kidney biopsy from a 7-year-old child with acute poststreptococcal glomerulonephritis. Periodic acid–Schiff stain (at 40x) shows the intracapillary and occasional mesangial neutrophil (arrows). Courtesy of Laura Kidd, MD, Pathology and Laboratory Medicine, Tulane University Medical School.
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Kidney biopsy from a 7-year-old child with acute poststreptococcal glomerulonephritis. Periodic acid–Schiff stain (at 40x) shows the intracapillary and occasional mesangial neutrophil (arrows). Courtesy of Laura Kidd, MD, Pathology and Laboratory Medicine, Tulane University Medical School.
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Kidney biopsy from a 7-year-old child with acute poststreptococcal glomerulonephritis. Electron microscopy image shows rare large subepithelial deposits, or “humps” (arrows). Courtesy of Laura Kidd, MD, Pathology and Laboratory Medicine, Tulane University Medical School.
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Kidney biopsy from a 7-year-old child with acute poststreptococcal glomerulonephritis. Electron microscopy image shows rare large subepithelial deposits, or “humps” (arrows). Courtesy of Laura Kidd, MD, Pathology and Laboratory Medicine, Tulane University Medical School.
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Kidney biopsy from a 7-year-old child with acute poststreptococcal glomerulonephritis. Immunofluorescence (C3) shows a granular capillary and mesangial staining pattern with segmental areas of “lumpy-bumpy” staining (white arrows). Courtesy of Laura Kidd, MD, Pathology and Laboratory Medicine, Tulane University Medical School.
